{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:50:06Z","timestamp":1791816606256,"version":"4.3.4"},"reference-count":26,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"01","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003To determine embryo quality (mean graduated embryo score [GES]) in infertile patients with endometriosis undergoing in vitro fertilization with embryo transfer (IVF-ET) compared with infertile patients without endometriosis.<\/jats:p><jats:p>\n          Methods\u2003A case-control study was performed comparing 706 embryos (162 patients) divided into 2 groups: 472 embryos derived from patients without endometriosis (n\u2009=\u2009109, infertile patients with tubal infertility) and 234 embryos from patients in the study group (n\u2009=\u200953, infertile patients with peritoneal endometriosis). All patients were subjected to IVF using an oestradiol-antagonist-recombinant follicle-stimulating hormone (FSH) protocol for ovarian stimulation. The mean GES was performed to evaluate all embryos at 3 points in time: 16 to 18\u2009hours, 25 to 27\u2009hours, and 64 to 67\u2009hours. Embryo evaluation was performed according to the following parameters: fragmentation, nucleolar alignment, polar body apposition, blastomere number\/morphology, and symmetry. The primary outcome measure was the mean GES score. We also compared fertilization, implantation, and pregnancy rates.<\/jats:p><jats:p>\n          Results\u2003Although the number of embryos transferred was greater in patients with endometriosis than in the control group (2.38\u2009\u00b1\u20090.66 versus 2.15\u2009\u00b1\u20090.54; p\u2009=\u20090.001), the mean GES was similar in both groups (71\u2009\u00b1\u200919.8 versus 71.9\u2009\u00b1\u200923.5; p\u2009=\u20090.881). Likewise, the fertilization rate was similar in all groups, being 61% in patients with endometriosis and 59% in the control group (p\u2009=\u20090.511). No significant differences were observed in the implantation (21% versus 22%; [p\u2009=\u20090.989]) and pregnancy rates (26.4% versus 28.4%; p\u2009=\u20090.989).<\/jats:p><jats:p>\n          Conclusion\u2003Embryo quality measured by the mean GES was not influenced by peritoneal endometriosis. Likewise, the evaluated reproductive outcomes were similar between infertile patients with and without endometriosis.<\/jats:p>","DOI":"10.1055\/s-0040-1721855","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T23:44:30Z","timestamp":1611963870000},"page":"028-034","source":"Crossref","is-referenced-by-count":1,"title":["The Graduated Embryo Score of Embryos from Infertile Women with and without Peritoneal Endometriosis"],"prefix":"10.61622","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9651-342X","authenticated-orcid":false,"given":"Juliana","family":"Caran","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-8798","authenticated-orcid":false,"given":"Vanessa Krebs","family":"Genro","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"},{"name":"Department of Obstetrics and Gynecology, Centro de Reprodu\u00e7\u00e3o Humana Insemine, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-7247","authenticated-orcid":false,"given":"Carlos Augusto Bastos de","family":"Souza","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-8963","authenticated-orcid":false,"given":"Jo\u00e3o Sabino","family":"Cunha-Filho","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"},{"name":"Department of Obstetrics and Gynecology, Centro de Reprodu\u00e7\u00e3o Humana Insemine, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/s1472-6483(10)60138-1","article-title":"IVF outcome in women with endometriosis in relation to tumour necrosis factor and anti-M\u00fcllerian hormone","volume":"18","author":"H Falconer","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"720","DOI":"10.2741\/e652","article-title":"Effects of early endometriosis on IVF-ET outcomes","volume":"5","author":"K Mekaru","year":"2013","journal-title":"Front Biosci (Elite Ed)"},{"issue":"01","key":"ref3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12958-016-0217-2","article-title":"The impact of endometriosis on 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