{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T05:10:38Z","timestamp":1691212238645},"reference-count":17,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>\n<jats:bold>Objectives<\/jats:bold>\u2003Inappropriate use of mannitol is a medical error seen frequently in pre-neurosurgical head injury (HI) care that may result in serious adverse effects. This study explored this medical error amongst HI patients in a Nigerian neurosurgery unit.<\/jats:p>\n<jats:p>\n<jats:bold>Methods<\/jats:bold>\u2003We performed a cross-sectional analysis of a prospective cohort of HI patients who were administered mannitol by their initial non-neurosurgical health care givers before referral to our center over a 22-month period.<\/jats:p>\n<jats:p>\n<jats:bold>Statistical Analysis<\/jats:bold>\u2003A statistical software was used for the analysis with which an \u03b1 value of &lt;0.05 was deemed clinically significant.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003Seventy-one patients were recruited: 17 (23.9%) from private hospitals, 13 (18.3%) from primary health facilities (PHFs), 20 (28.2%) from secondary health facilities (SHFs), and 21 (29.6%) from tertiary health facilities (THFs). Thirteen patients (18.3%) had mild HI; 29 (40.8%) each had moderate and severe HI, respectively. Pupillary abnormalities were documented in five patients (7.04%) with severe HI and neurological deterioration in two with mild HI.<\/jats:p>\n<jats:p>Mannitol administration was deemed appropriate in only 43.7% (31\/71). Data on mannitol dosing in 60.6% (43\/71) of the patients showed 8\/43 (18.6%) receiving continuous 10% mannitol infusion. The remaining 35\/43 received mannitol as a 20% solution but also showing dosing error in 62.9% (22\/35): overdosing in 7\/35 (20%), and nonbolus administration in 15\/35 (42.9%). The distribution of the dosing error among the referring health facilities (all the 13 [100%] patients from private hospitals, 66.7% from PHF, 60% from SHF, and 45.5% from THF) showed a trend of better performance (<jats:italic>p<\/jats:italic> = 0.002) by the THFs.<\/jats:p>\n<jats:p>\n<jats:bold>Conclusion<\/jats:bold>\u2003Mannitol use is apparently fraught with an understudied medical error in the pre-neurosurgical care of the head injured.<\/jats:p>","DOI":"10.1055\/s-0040-1722093","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T23:36:23Z","timestamp":1611963383000},"page":"171-176","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mannitol Dosing Error during Pre-neurosurgical Care of Head Injury: A Neurosurgical In-Hospital Survey from Ibadan, Nigeria"],"prefix":"10.25259","volume":"12","author":[{"given":"Amos Olufemi","family":"Adeleye","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Neurological Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria"},{"name":"Department of Neurological Surgery, University College Hospital, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyin Ayofe","family":"Oyemolade","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University College Hospital, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toluyemi Adefolarin","family":"Malomo","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University College Hospital, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oghenekevwe Efe","family":"Okere","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University College Hospital, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"issue":"2","key":"10.1055\/s-0040-1722093\/ref-1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000182821","article-title":"Clinicoepidemiological profiles and outcomes during first hospital admission of head injury patients in Ikeja, Nigeria. 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