{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:36:26Z","timestamp":1788550586459,"version":"build-2803163510"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg J (N Y)"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Incidental gallbladder cancer is relatively rare, with an incidence ranging between 0.19 and 5.5% of all the cholecystectomies for benign disease, and carries a poor prognosis. Currently, in the literature, there appears to be some controversy about whether all gallbladder specimens should be sent for routine histopathology. The aim of this study was to investigate the need for either routine or selective histopathological evaluation of all gallbladder specimens following cholecystectomy in our institution.<\/jats:p><jats:p>\n          Methods\u2003The records of all patients who underwent a cholecystectomy (laparoscopic and open) for gallstone disease over a 5-year period (between January 2011 and January 2016) were reviewed retrospectively in a single university teaching hospital. Patients with radiological evidence of gallbladder cancer preoperatively were excluded. The notes of patients with incidental gallbladder cancer were reviewed and data were collected for clinical presentation and preoperative investigations including blood tests and radiological imaging.<\/jats:p><jats:p>\n          Results\u2003A total of 1,473 specimens were sent for histopathological evaluation, with two patients being diagnosed with an incidental gallbladder cancer (papillary adenocarcinoma in situ and moderately differentiated invasive adenocarcinoma [stage IIIa]). The incidence rate was 0.14%. All patients with incidental gallbladder cancer had macroscopically abnormal specimens.<\/jats:p><jats:p>\n          Conclusion\u2003Both patients in our study who were diagnosed with incidental gallbladder cancer had macroscopic abnormalities. A selective rather than routine approach to histological evaluation of gallbladder specimens especially in those with macroscopic abnormalities should be employed. This will reduce the burden on the pathology department with potential cost savings.<\/jats:p>","DOI":"10.1055\/s-0040-1722175","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T03:50:24Z","timestamp":1612237824000},"page":"e22-e25","source":"Crossref","is-referenced-by-count":15,"title":["Incidental Gallbladder Cancer: Routine versus Selective Histological Examination After Cholecystectomy"],"prefix":"10.1055","volume":"07","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-5504","authenticated-orcid":false,"given":"Andrew","family":"Alabi","sequence":"additional","affiliation":[{"name":"Department of Surgery, West Middlesex University Hospital, Chelsea and Westminster NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-0628","authenticated-orcid":false,"given":"A D.","family":"Arvind","sequence":"additional","affiliation":[{"name":"School of Medicine, Imperial College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Pawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, West Middlesex University Hospital, Chelsea and Westminster NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakir","family":"Karim","sequence":"additional","affiliation":[{"name":"Department of Histopathology, West Middlesex University Hospital, Chelsea and Westminster NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Surgery, West Middlesex University Hospital, Chelsea and Westminster NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/bjs.4547","article-title":"Development of symptoms and complications in individuals with asymptomatic gallstones","volume":"91","author":"I Halldestam","year":"2004","journal-title":"Br J Surg"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/bjs.5266","article-title":"Bile duct injury in the era of laparoscopic cholecystectomy","volume":"93","author":"S Connor","year":"2006","journal-title":"Br J Surg"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.suc.2008.07.008","article-title":"Cholecystitis","volume":"88","author":"D R Elwood","year":"2008","journal-title":"Surg Clin North Am"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1148\/radiographics.21.2.g01mr16295","article-title":"Gallbladder carcinoma: radiologic-pathologic correlation","volume":"21","author":"A D Levy","year":"2001","journal-title":"Radiographics"},{"issue":"01","key":"ref6","first-page":"85","article-title":"Incidental gall bladder carcinoma in laparoscopic cholecystectomy: a report of 6 cases and a review of the literature","volume":"7","author":"J Sujata","year":"2013","journal-title":"J Clin Diagn Res"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1053\/ejso.2002.1402","article-title":"Incidental finding of gallbladder carcinoma detected during or after laparoscopic cholecystectomy","volume":"29","author":"P Antonakis","year":"2003","journal-title":"Eur J Surg Oncol"},{"issue":"S 02","key":"ref8","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1016\/j.ijsu.2014.08.367","article-title":"Managing the incidentally detected gallbladder cancer: algorithms and controversies","volume":"12","author":"A Cavallaro","year":"2014","journal-title":"Int J Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1159\/000357259","article-title":"Is it necessary to send gallbladder specimens for routine histopathological examination after cholecystectomy? 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