{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:59:12Z","timestamp":1780376352661,"version":"3.54.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The aim of this study is to test if the newly proposed 45\u2009mm size criterion for ascending aortic replacement (AAR) in bicuspid aortic valve (BAV) patients undergoing aortic valve replacement (AVR) is predictive of improved early outcomes.<\/jats:p><jats:p>\n          Methods\u2003Data of 306 BAV patients with an aortic diameter of \u226545\u2009mm undergoing AVR alone or with AAR were retrospectively analyzed. Patients were divided into groups of AVR\u2009+\u2009AAR (n\u2009=\u2009220) and AVR only (n\u2009=\u200986) based on if surgery was performed according to the 45 mm criterion. End point was early adverse events, including 30-day and in-hospital mortality, cardiac events, acute renal failure, stroke, and reoperation for bleeding. Cox regression was used to assess if conformance to 45\u2009mm criterion could predict fewer early adverse events.<\/jats:p><jats:p>\n          Results\u2003AVR\u2009+\u2009AAR group had significantly higher postoperative left ventricular ejection fraction (LVEF) (0.59\u2009\u00b1\u20090.09 vs. 0.55\u2009\u00b1\u20090.11, p\u2009=\u20090.006) and longer cardiopulmonary bypass (CPB) time (128 vs. 111\u2009minutes, p\u2009=\u20090.002). Early adverse events occurred in 45 patients (14.7%), which was more prevalent in the AVR-only group (22.1% vs. 11.8%, p\u2009=\u20090.020). Conformance to the 45\u2009mm criterion predicted lower rate of early adverse events (hazard ratio [HR]: 0.53, 95% confidence interval [CI]: 0.28\u20130.98, p\u2009=\u20090.042). After adjustment for gender, age, AAo diameter, sinuses of Valsalva diameter, preoperative LVEF, Sievers subtypes, BAV valvulopathy, and CPB and cross-clamp times, conformance to the 45 mm size criterion still predicted lower incidence of early adverse events (HR: 0.37, 95% CI: 0.15\u20130.90, p\u2009=\u20090.028).<\/jats:p><jats:p>\n          Conclusions\u2003This study shows that conformance to 45 mm size cutoff for preemptive AAR during aortic valve replacement in patients with BAV was not associated with increased risk for adverse events and may improve early surgical outcomes.<\/jats:p>","DOI":"10.1055\/s-0040-1722197","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:05:58Z","timestamp":1611101158000},"page":"289-296","source":"Crossref","is-referenced-by-count":2,"title":["Does the 45\u2009mm Size Cutoff for Ascending Aortic Replacement Predict Better Early Outcomes in Bicuspid Aortic Valve?"],"prefix":"10.1055","volume":"70","author":[{"given":"Yi-Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3873-0837","authenticated-orcid":false,"given":"Wei-Guo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Zhong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 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