{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:45:48Z","timestamp":1789926348246,"version":"4.0.1"},"reference-count":123,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"Earl & Nyda Swanson Neurosciences Research Fund and the Harley N."},{"name":"Rebecca N. Hotchkiss Endowed Fund in Neuroscience Research, Honoring Ken and Marietta"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite substantial advances in stroke care, vascular cognitive impairment remains a prominent source of disability. Unlike sensorimotor impairments, cognition often continues to decline after stroke. An aging population will increase the prevalence of vascular cognitive impairment, with stroke playing an important role. Ten percent of patients presenting with stroke have pre-stroke dementia; an additional 10% will develop incident dementia with a first stroke, and 30% with a recurrent stroke. While stroke increases the risk of cognitive impairment, the presence of cognitive impairment also impacts acute stroke treatment and increases risk of poor outcome by nearly twofold. There is substantial overlap in the clinical and pathological aspects of vascular and degenerative dementias in many patients. How they relate to one another is controversial. The treatment of vascular cognitive impairment remains supportive, focusing on treating vascular risk factors. Cognitive rehabilitation after stroke is an area of active research, and existing pharmacologic treatments have limited benefit. Heightened awareness of cognitive impairment in the setting of stroke is imperative for prognostication and management, impetus for research and, ultimately, the discovery of efficacious treatments.<\/jats:p>","DOI":"10.1055\/s-0040-1722217","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T22:35:53Z","timestamp":1610145353000},"page":"075-084","source":"Crossref","is-referenced-by-count":28,"title":["Cognitive Impairment in Patients with Stroke"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9799-8246","authenticated-orcid":false,"given":"Caitlin E.","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic Florida, Jacksonville, Florida"},{"name":"Department of Neurology, Baptist Health, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9638-9951","authenticated-orcid":false,"given":"Melanie R. F.","family":"Greenway","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic Florida, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Graff-Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic Rochester, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-8142","authenticated-orcid":false,"given":"James F.","family":"Meschia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic Florida, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.3233\/JAD-189011","article-title":"Atherosclerosis, hypertension, and diabetes in Alzheimer's disease, vascular dementia, and mixed dementia: prevalence and presentation","volume":"66","author":"K Javanshiri","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"J T O'Brien","year":"2015","journal-title":"Lancet"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"42","author":"P B Gorelick","year":"2011","journal-title":"Stroke"},{"issue":"24","key":"ref4","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"J A Schneider","year":"2007","journal-title":"Neurology"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.1997.03540340047031","article-title":"Brain infarction and the clinical expression of Alzheimer disease. 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