{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:35:22Z","timestamp":1788561322259,"version":"build-2803163510"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>\n            Objective\u2003The study aimed to evaluate the efficacy of dual medication therapy (DMT) with oral acetaminophen and oral ibuprofen for the closure of a hemodynamically significant patent ductus arteriosus (hsPDA).<\/jats:p><jats:p>\n            Study Design\u2003In a prospective case\u2013control cohort study (July 2017\u2013May 2019), infants &lt;29 weeks' gestational age and birth weight &lt;1,000\u2009g at \u226414 postnatal days with hsPDA and ratio of the smallest ductal diameter to the ostium of the left pulmonary artery diameter &gt;0.5 were eligible. Infants received 10\u2009mg\/kg oral ibuprofen followed by two additional doses of 5\u2009mg\/kg at 24 and 48\u2009hours after the initial ibuprofen dose and concomitant treatment with 15\u2009mg\/kg oral acetaminophen every 6\u2009hours for 3 days (12 doses). Success of PDA treatment was defined as a small or absent PDA as ascertained by echocardiographic measurements. The p-values of comparisons were adjusted for multiple comparisons to preserve an error rate of 5%.<\/jats:p><jats:p>\n            Results\u2003Overall, 20 infants received oral DMT and 11 infants received intravenous single medication therapy (SMT) with ibuprofen. The rates of successful PDA treatment following the first treatment in DMT and SMT groups were not statistically different (11\/20 [55%] vs. 4\/11 [36%], p\u2009=\u20090.46). However, DMT significantly decreased PDA size (mean difference\u2009=\u20090.54\u2009mm, 95% confidence interval [CI]: 0.21\u20130.96, adjusted p-value\u2009=\u20090.0002) and PDA\/LPA ratio (mean difference\u2009=\u20090.27, 95% CI: 0.10\u20130.47, adjusted p-value\u2009=\u20090.0004). We observed no evidence of hematologic, hepatic, or renal impairment.<\/jats:p><jats:p>\n            Conclusion\u2003DMT achieved a greater degree of PDA closure than SMT and did not result in abnormalities in hepatic and renal profile.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1722329","type":"journal-article","created":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T23:31:35Z","timestamp":1610926295000},"page":"1326-1333","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness of Dual Medication Therapy (Oral Acetaminophen and Oral Ibuprofen) for the Management of Patent Ductus Arteriosus in Extremely Premature Infants: A Feasibility Trial"],"prefix":"10.1055","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1033-0156","authenticated-orcid":false,"given":"Sanket D.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Florida College of Medicine, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartikeya","family":"Makker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Johns Hopkins Children's Center, John Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padma","family":"Nandula","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Florida College of Medicine, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Smotherman","sequence":"additional","affiliation":[{"name":"Center for Data Solutions, University of Florida College of Medicine, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kropf","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Hudak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Florida College of Medicine, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,1,17]]},"reference":[{"issue":"03","key":"ref1","first-page":"138","article-title":"Patent ductus arteriosus: an overview","volume":"12","author":"J E Dice","year":"2007","journal-title":"J Pediatr Pharmacol Ther"},{"issue":"17","key":"ref2","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1161\/CIRCULATIONAHA.105.592063","article-title":"Patent ductus arteriosus","volume":"114","author":"D J 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Concerning the article by M.Y. Oncel et al: intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants [Neonatology 2013;103:166-169]","volume":"104","author":"K S Tekgunduz","year":"2013","journal-title":"Neonatology"},{"issue":"02","key":"ref39","first-page":"134","article-title":"Acetaminophen serum concentrations in infants treated intravenously for patent ductus arteriosus","volume":"24","author":"C McPherson","year":"2019","journal-title":"J Pediatr Pharmacol Ther"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1722329.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T23:27:52Z","timestamp":1661988472000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1722329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,17]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,8,31]]},"published-print":{"date-parts":[[2022,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1722329","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,17]]}}}