{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:36:08Z","timestamp":1778837768328,"version":"3.51.4"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>\n            Objective\u2003Multiple randomized controlled trials have shown that hypothermia is a safe and effective treatment for neonatal moderate or severe hypoxic-ischemic encephalopathy (HIE). The neuroprotective mechanisms of hypothermia need further study. The aim of this study was to investigate the effect of hypothermia on the serum levels of myelin basic protein (MBP) and tumor necrosis factor-\u03b1 (TNF-\u03b1) as well as neurodevelopmental outcomes in neonatal HIE.<\/jats:p><jats:p>\n            Study Design\u2003Eighty-five neonates with moderate-to-severe HIE were divided into a hypothermia group (n\u2009=\u200949) and a control group (n\u2009=\u200936). Serum levels of MBP and TNF-\u03b1 within 6\u2009hours after birth and after 3 days of treatment were determined by enzyme-linked immunosorbent assay, and neurodevelopmental outcome at the age of 12 to 15 months was assessed by using the Gesell development scale.<\/jats:p><jats:p>\n            Results\u2003After 3 days of treatment, serum levels of MBP and TNF-\u03b1 in the control group were not significantly different from levels before treatment (p\u2009&gt;\u20090.05), and serum levels of MBP and TNF-\u03b1 in the hypothermia group were significantly lower than levels before treatment (p\u2009&lt;\u20090.05). Serum levels of MBP and TNF-\u03b1 were significantly negatively correlated with developmental quotient (DQ; r\u2009=\u2009\u2009\u2212\u20090.7945, p\u2009=\u20090.0000; r\u2009=\u2009\u2009\u2212\u20090.7035, p\u2009=\u20090.0000, respectively). Serum levels of MBP and TNF-\u03b1 in neurodevelopmentally impaired infants were significantly higher than those in infants with suspected neurodevelopmental impairment and those in neurodevelopmentally normal infants (both p\u2009&lt;\u20090.01). The rate of reduction of neurodevelopmental impairment was higher among infants in the hypothermia group than among those in the control group (\u03c72\u2009=\u200916.3900, p\u2009&lt;\u20090.05).<\/jats:p><jats:p>\n            Conclusion\u2003Hypothermia can reduce serum levels of MBP and TNF-\u03b1 in neonates with HIE. Inhibiting the release of TNF-\u03b1 may be one of the mechanisms by which hypothermia protects the myelin sheath.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1722601","type":"journal-article","created":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T23:31:35Z","timestamp":1610926295000},"page":"1367-1374","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Hypothermia on Serum Myelin Basic Protein and Tumor Necrosis Factor\u2013\u03b1 in Neonatal Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1055","volume":"39","author":[{"given":"Qiuli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, People's Republic of China"},{"name":"Department of Neonatal Pathology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihua","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengshun","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neonatal Pathology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, People's Republic of China"},{"name":"Department of Neural Development and Neural Pathology, Hebei University of Engineering School of Medicine, Handan, Hebei Province, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,1,17]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"J J Kurinczuk","year":"2010","journal-title":"Early Hum Dev"},{"issue":"01","key":"ref2","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"S E Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/archpediatrics.2011.43","article-title":"Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial","volume":"165","author":"S E Jacobs","year":"2011","journal-title":"Arch Pediatr 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