{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:33Z","timestamp":1740126813906,"version":"3.37.3"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>\n            Objective\u2003Transient tachypnea of the newborn (TTN), a common neonatal respiratory morbidity, is associated with failure of adequate clearance of fetal lung fluid. Glucocorticoids have an important role in lung maturity and the mechanisms of lung fluid clearance. The aim of this study is to assess the association between umbilical cord cortisol levels and transient TTN in late preterm and term neonates delivered by elective cesarean section (CS).<\/jats:p><jats:p>\n            Study Design\u2003A case-control study of 37 newborns diagnosed with TTN (cases) was compared with 40 healthy newborns (controls). All infants were delivered by elective CS without labor. Umbilical cord cortisol levels were measured using enzyme-linked immunosorbent assay.<\/jats:p><jats:p>\n            Results\u2003Mean cord cortisol levels were significantly lower in cases than controls (131.36 vs. 233.32 nmol\/L, p\u2009=\u20090.0001; odds ratio [OR]\u2009=\u20093.7; 95% confidence interval [CI]: 1.40\u20139.53), respectively. Cord serum cortisol correlated inversely with the duration of tachypnea and the respiratory rate (r\u2009=\u2009\u2009\u2212\u20090.678 and \u22120.535, respectively).<\/jats:p><jats:p>\n            Conclusion\u2003Umbilical cord cortisol levels are significantly lower in newborns with transient TTN, and lower cortisol levels are associated with an increased respiratory rate and longer duration of admission. Antenatal glucocorticoids can be recommended for late preterm delivered by CS.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1722603","type":"journal-article","created":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T23:31:35Z","timestamp":1610926295000},"page":"1254-1260","source":"Crossref","is-referenced-by-count":1,"title":["Association between Low Cord Serum Cortisol Level and Transient Tachypnea of the Newborn in Late Preterm and Term Neonates Delivered by Elective Cesarean Section"],"prefix":"10.1055","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5921-4770","authenticated-orcid":false,"given":"Raid M.R.","family":"Umran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Kufa, Al-Zahraa Teaching Hospital, Najaf Health Directorate, Najaf, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roaa M.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Al-Zahraa Teaching Hospital, Najaf Health Directorate, Najaf, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,1,17]]},"reference":[{"key":"ref1","first-page":"1197","volume-title":"Neonatal morbidities of prenatal and perinatal origin","author":"J Greenberg","year":"2009","edition":"6th ed."},{"key":"ref2","first-page":"364","volume-title":"Transient Tachypnea of Newborn","author":"K A Kiensta","year":"2012","edition":"7th ed."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1542\/neo.7-2-e88","article-title":"Clearance of fluid from airspaces of newborns and infants","volume":"7","author":"N Elias","year":"2006","journal-title":"Neoreviews"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1201\/b13191","volume-title":"Neonatal Respiratory Disorders","author":"A 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