{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:29:47Z","timestamp":1787956187613,"version":"build-2784847793"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n            Objective\u2003The incidence of patent ductus arteriosus (PDA), a major complication of prematurity, may be reduced by restricting fluid administration. Prophylactic fresh frozen plasma (FFP) transfusion may reduce the incidence of intraventricular hemorrhage in these infants, but risks transfusion-related volume overload. We conducted a retrospective study to investigate whether FFP transfusion is a risk factor for hemodynamically significant PDA (hsPDA) in very low birth weight (BW) premature infants.<\/jats:p><jats:p>\n            Study Design\u2003From January 2009 to December 2014, 102 premature infants with gestational age (GA) less than or equal to 30 weeks were admitted to a level III neonatal intensive care unit, and 88 patients were enrolled. Patients were further divided into non-hsPDA (n\u2009=\u200929) and hsPDA groups (n\u2009=\u200959). We retrospectively reviewed demographic characteristics and various perinatal and postnatal variables. Univariate and multivariable analyses were performed to identify risk factors for hsPDA.<\/jats:p><jats:p>\n            Results\u2003Compared with non-hsPDA patients, hsPDA patients had lower mean BW and GA, a higher incidence of severe respiratory distress symptoms, perinatal infection, use of surfactant, and need for FFP transfusion. However, multivariable logistic regression analysis showed that only FFP transfusion remained an independent risk factor for hsPDA (adjusted odds ratio =\u20093.880,\u200995% confidence interval: 1.214\u201312.402, p\u2009=\u20090.022) after adjusting for confounding factors.<\/jats:p><jats:p>\n            Conclusion\u2003FFP transfusion is a significant risk factor for the subsequent development of hsPDA in our study population. FFP transfusion may complicate the fluid management of premature infants and increase the risk of hsPDA.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1722649","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T23:34:41Z","timestamp":1611531281000},"page":"1426-1432","source":"Crossref","is-referenced-by-count":5,"title":["Fresh Frozen Plasma Transfusion: An Independent Risk Factor for Hemodynamically Significant Patent Ductus Arteriosus in Premature Infants"],"prefix":"10.1055","volume":"39","author":[{"given":"Chun-Pin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cathay General Hospital, Hsinchu Branch, Hsinchu, Taiwan"},{"name":"Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Li","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Shiun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan"},{"name":"Department of Pediatrics, National Taiwan University Children's Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Min","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan"},{"name":"School of Medical, Fu-Jen Catholic University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,1,24]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.siny.2018.05.001","article-title":"Patent ductus arteriosus: the physiology of transition","volume":"23","author":"P Deshpande","year":"2018","journal-title":"Semin Fetal Neonatal Med"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2165\/11632870-000000000-00000","article-title":"Patent ductus arteriosus in premature neonates","volume":"72","author":"O J Mezu-Ndubuisi","year":"2012","journal-title":"Drugs"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41390-019-0342-7","article-title":"The definition of a hemodynamically significant ductus arteriosus","volume":"85","author":"A El-Khuffash","year":"2019","journal-title":"Pediatr Res"},{"issue":"01","key":"ref4","first-page":"21","article-title":"What is a hemodynamically significant PDA in preterm infants?","volume":"14","author":"J L Shepherd","year":"2019","journal-title":"Congenit Heart Dis"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1053\/j.semperi.2018.05.006","article-title":"Patent ductus arteriosus, its treatments, and the risks of pulmonary morbidity","volume":"42","author":"R I Clyman","year":"2018","journal-title":"Semin Perinatol"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.jpeds.2015.03.012","article-title":"Association between hemodynamically significant patent ductus arteriosus and bronchopulmonary dysplasia","volume":"166","author":"F Schena","year":"2015","journal-title":"J Pediatr"},{"issue":"07","key":"ref7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/sj.jp.7210795","article-title":"Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus","volume":"22","author":"A M Fujii","year":"2002","journal-title":"J Perinatol"},{"issue":"19","key":"ref8","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1080\/14767058.2018.1460349","article-title":"The effect of hemodynamically significant patent ductus arteriosus on acute kidney injury and systemic hypertension in extremely low gestational age newborns","volume":"32","author":"D M Velazquez","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"F505","DOI":"10.1136\/archdischild-2013-303816","article-title":"Morbidity and mortality in preterm neonates with patent ductus arteriosus on day 3","volume":"98","author":"A Sellmer","year":"2013","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"24","key":"ref10","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1001\/jama.2015.6734","article-title":"Hemodynamic EPIPAGE 2 study group. 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