{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:27:25Z","timestamp":1777289245451,"version":"3.51.4"},"reference-count":75,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003To analyze the relationship between preoperative and intraoperative auditory brain stem response (ABR) characteristics and hearing outcomes in patients with vestibular schwannomas (VS) undergoing hearing preservation (HP) surgery via a middle cranial fossa (MCF) approach.<\/jats:p><jats:p>\n          Design\u2003Prospective study.<\/jats:p><jats:p>\n          Setting\u2003Academic tertiary skull base referral center.<\/jats:p><jats:p>\n          Methods\u2003Pre- and postoperative pure-tone average (PTA) and word recognition score (WRS) were examined. Intraoperative ABR wave III latency, wave V latency, and amplitude were recorded. HP was defined as postoperative WRS \u226550%.<\/jats:p><jats:p>\n          Participants\u2003Adult patients with VS and WRS \u226550% who underwent MCF tumor resection between November 2017 and September 2019.<\/jats:p><jats:p>\n          Main Outcome Measures\u2003Postoperative hearing outcomes.<\/jats:p><jats:p>\n          Results\u2003Sixty patients were included. Mean tumor size was 9.2\u2009mm (range, 3\u201317). HP rates were 56.7% for the cohort and 69.7% for tumors &lt;10\u2009mm. A complete loss of wave V was associated with an 82.9% increase in postoperative PTA (p\u2009&lt;\u20090.001) and 97.2% decrease in WRS (p\u2009&lt;\u20090.001), whereas a diminished wave V was correlated with 62.7% increase in PTA (p\u2009&lt;\u20090.001) and 55.7% decrease in WRS (p\u2009=\u20090.006). A diminished or absent wave V, but not increased wave III\/V latency or decreased wave V amplitude, was correlated with a decline in postoperative hearing class (r\u2009=\u20090.735, p\u2009&lt;\u20090.001). Receiver-operating characteristic analysis demonstrated that a stable wave V has the highest accuracy in predicting HP (sensitivity of 82.6%, specificity of 84.8%).<\/jats:p><jats:p>\n          Conclusion\u2003Of the examined preoperative and intraoperative ABR characteristics, a stable wave V intraoperatively was the strongest predictor of HP after MCF resection of VS.<\/jats:p><jats:p>\n          Level of Evidence\u2003Level III.<\/jats:p>","DOI":"10.1055\/s-0040-1722718","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T23:58:26Z","timestamp":1611273506000},"page":"496-504","source":"Crossref","is-referenced-by-count":5,"title":["Auditory Brain Stem Response Predictors of Hearing Outcomes after Middle Fossa Resection of Vestibular Schwannomas"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3865-0012","authenticated-orcid":false,"given":"Yin","family":"Ren","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M.","family":"Merna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Irvine, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kareem O.","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, United States"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc S.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of California, San Diego, San Diego, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick A.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1001\/archotol.127.5.543","article-title":"Facial function in hearing preservation acoustic neuroma surgery","volume":"127","author":"M A 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