{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:42:55Z","timestamp":1794487375514,"version":"4.9.1"},"reference-count":24,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>\n<jats:bold>Introduction<\/jats:bold>\u2003Anxiety is common in patients with Parkinson\u2019s disease (PD). Its prevalence ranges from 20 to 40% but despite that, the high prevalence anxiety in PD is often undiagnosed and untreated. This research was aimed to study the pattern of anxiety with regard to its prevalence and risk factors and to establish the association of anxiety with depression and quality of life (QOL) in patients with PD.<\/jats:p>\n<jats:p>\n<jats:bold>Methods<\/jats:bold>\u2003A total of 105 patients with PD were prospectively observed. Demographic and clinical variables were recorded and patients were assessed for anxiety (the Parkinson anxiety scale [PAS]), depression (geriatric depression scale [GDS]), and QOL (Parkinson\u2019s Disease Questionnaire-39 [PDQ-39]). Multiple forward logistic regression analysis was done for parameters showing association with anxiety. Pearson\u2019s correlation was used to calculate the strength of association of depression and QOL with anxiety.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003Anxiety was present in 56 PD patients (53.3%). Episodic anxiety was noted in 50%, avoidance behavior in 35%, and persistent anxiety in 15% of these patients. There was significant association of anxiety with duration of disease (<jats:italic>p<\/jats:italic> = 0.001), severity (<jats:italic>p<\/jats:italic> &lt; 0.005), levodopa equivalent dose (LED; <jats:italic>p<\/jats:italic> = 0.001), and tremor phenotype of PD (<jats:italic>p<\/jats:italic> = 0.004). Anxiety coexisted with depression in 50 patients (79.4%), which was statistically significant in our cohort (<jats:italic>p<\/jats:italic> = 0.001). There was significant linear relationship between the PAS and PDQ-39.<\/jats:p>\n<jats:p>\n<jats:bold>Conclusion<\/jats:bold>\u2003Anxiety exerts a negative impact on the QOL as revealed by proportionately worsening PDQ-39 and PAS scores. Screening for anxiety will allow efficient delivery of support and treatment to patients with PD and their families.<\/jats:p>","DOI":"10.1055\/s-0041-1722840","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:30:54Z","timestamp":1619224254000},"page":"323-328","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Anxiety in Parkinson\u2019s Disease: Correlation with Depression and Quality of Life"],"prefix":"10.25259","volume":"12","author":[{"given":"Ankush","family":"Upneja","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, All India Institute of Medical Sciences, Bathinda, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birinder S.","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dayanand Medical College and Hospital, Ludhiana, Punjab, 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