{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:41:48Z","timestamp":1780990908298,"version":"3.54.1"},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n            Objective\u2003We examined the effects of maternal hypertensive disorders of pregnancy (HDP) on the mortality and neurodevelopmental outcomes in preterm very low birth weight (VLBW) infants (BW \u22641,500\u2009g) based on their intrauterine growth status and gestational age (GA).<\/jats:p><jats:p>\n            Study Design\u2003We included singleton VLBW infants born at &lt;32 weeks' gestation registered in the Neonatal Research Network Japan database. The composite outcomes including death, cerebral palsy (CP), and developmental delay (DD) at 3 years of age were retrospectively compared among three groups: appropriate for GA (AGA) infants of mothers with and without HDP (H-AGA and N-AGA) and small for GA (SGA) infants of mothers with HDP (H-SGA). The adjusted odds ratios (AOR) and 95% confidence intervals (CI) stratified by the groups of every two gestational weeks were calculated after adjusting for the center, year of birth, sex, maternal age, maternal diabetes, antenatal steroid use, clinical chorioamnionitis, premature rupture of membranes, non-life-threatening congenital anomalies, and GA.<\/jats:p><jats:p>\n            Results\u2003Of 19,323 eligible infants, outcomes were evaluated in 10,192 infants: 683 were H-AGA, 1,719 were H-SGA, and 7,790 were N-AGA. Between H-AGA and N-AGA, no significant difference was observed in the risk for death, CP, or DD in any GA groups. H-AGA had a lower risk for death, CP, or DD than H-SGA in the 24 to 25 weeks group (AOR: 0.434, 95% CI: 0.202\u20130.930). The odds for death, CP, or DD of H-SGA against N-AGA were found to be higher in the 24 to 25 weeks (AOR: 2.558, 95% CI: 1.558\u20133.272) and 26 to 27 weeks (AOR: 1.898, 95% CI: 1.427\u20132.526) groups, but lower in the 30 to 31 weeks group (AOR: 0.518, 95% CI: 0.335\u20130.800).<\/jats:p><jats:p>\n            Conclusion\u2003There was a lack of follow-up data; however, the outcomes of liveborn preterm VLBW infants of mothers with HDP depended on their intrauterine growth status and GA at birth.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1722874","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:39:04Z","timestamp":1612399144000},"page":"1465-1477","source":"Crossref","is-referenced-by-count":10,"title":["A Retrospective Cohort Study on Mortality and Neurodevelopmental Outcomes of Preterm Very Low Birth Weight Infants Born to Mothers with Hypertensive Disorders of Pregnancy"],"prefix":"10.1055","volume":"39","author":[{"given":"Yumi","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Yonemoto","sequence":"additional","affiliation":[{"name":"Department of Psychoneuropharmacology, National institute of Mental Health, National Center of Neurology and Psychiatry, Kodira, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiko","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care Medicine, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeharu","family":"Hosono","sequence":"additional","affiliation":[{"name":"Department of Perinatal and Neonatal Medicine, Jichi Medical University Saitama Medical Center, Saitama, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kusuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kyorin University, Mitaka, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Neonatal Research Network 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Gagliardi","year":"2019","journal-title":"Pediatr Res"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"635.e1","DOI":"10.1016\/j.ajog.2019.06.028","article-title":"Fetal growth patterns in pregnancy-associated hypertensive disorders: NICHD Fetal Growth Studies","volume":"221","author":"J Mateus","year":"2019","journal-title":"Am J Obstet Gynecol"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3109\/14767058.2014.928853","article-title":"Effects of smoking and preeclampsia on birth weight for gestational age","volume":"28","author":"C N Spracklen","year":"2015","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/aogs.13702","article-title":"Early-onset fetal growth restriction: a systematic review on mortality and morbidity","volume":"99","author":"A Pels","year":"2020","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/uog.15884","article-title":"Consensus definition of fetal growth restriction: a Delphi procedure","volume":"48","author":"S J Gordijn","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2188\/jea.JE20100123","article-title":"Distribution of birth weight for gestational age in Japanese infants delivered by cesarean section","volume":"21","author":"R Uehara","year":"2011","journal-title":"J Epidemiol"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"e20172533","DOI":"10.1542\/peds.2017-2533","article-title":"Morbidity and mortality in small for gestational age infants at 22 to 29 weeks' gestation","volume":"141","author":"N S Boghossian","year":"2018","journal-title":"Pediatrics"},{"issue":"05","key":"ref13","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jpeds.2010.05.002","article-title":"Impact of fetal growth restriction on mortality and morbidity in a very preterm birth cohort","volume":"157","author":"J Zeitlin","year":"2010","journal-title":"J Pediatr"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"e0125769","DOI":"10.1371\/journal.pone.0125769","article-title":"Being small for gestational age: does it matter for the neurodevelopment of premature infants? 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Therapeutic decisions based upon clinical staging","volume":"187","author":"M J Bell","year":"1978","journal-title":"Ann Surg"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1469-8749.1964.tb10791.x","article-title":"Terminology and classification of cerebral palsy","volume":"6","author":"M C Bax","year":"1964","journal-title":"Dev Med Child Neurol"},{"issue":"04","key":"ref29","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1469-8749.1997.tb07414.x","article-title":"Development and reliability of a system to classify gross motor function in children with cerebral palsy","volume":"39","author":"R Palisano","year":"1997","journal-title":"Dev Med Child Neurol"},{"key":"ref30","volume-title":"Shiki Hattatsu Kensahou SK, 2001 Nenban [the Kyoto Scale of Psychological Development Test 2001","author":"Society for the Kyoto Scale of Psychological Development Test","year":"2008"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.braindev.2015.10.010","article-title":"Developmental assessment of VLBW infants at 18 months of age: a comparison study between KSPD and Bayley III","volume":"38","author":"Y Kono","year":"2016","journal-title":"Brain Dev"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2393-4-17","article-title":"The effect of hypertensive disorders in pregnancy on small for gestational age and stillbirth: a population based study","volume":"4","author":"V M Allen","year":"2004","journal-title":"BMC Pregnancy Childbirth"},{"issue":"07","key":"ref34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5694\/j.1326-5377.2005.tb06730.x","article-title":"Hypertensive disorders in pregnancy: a population-based study","volume":"182","author":"C L Roberts","year":"2005","journal-title":"Med J Aust"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpobgyn.2018.04.003","article-title":"The global epidemiology of preterm birth","volume":"52","author":"J P Vogel","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"01","key":"ref36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.clp.2013.09.003","article-title":"Neurodevelopmental outcomes of extremely preterm infants","volume":"41","author":"B R Vohr","year":"2014","journal-title":"Clin Perinatol"},{"issue":"04","key":"ref37","doi-asserted-by":"crossref","first-page":"e883","DOI":"10.1542\/peds.2010-2442","article-title":"Neurologic outcomes at school age in very preterm infants born with severe or mild growth restriction","volume":"127","author":"I Guellec","year":"2011","journal-title":"Pediatrics"},{"issue":"06","key":"ref38","doi-asserted-by":"crossref","first-page":"e20174286","DOI":"10.1542\/peds.2017-4286","article-title":"Neurodevelopmental outcomes in infants with birth weight \u2264500\u2009g at 3 years of age","volume":"142","author":"H Inoue","year":"2018","journal-title":"Pediatrics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"l5678","DOI":"10.1136\/bmj.l5678","article-title":"Association of early postnatal transfer and birth outside a tertiary hospital with mortality and severe brain injury in extremely preterm infants: observational cohort study with propensity score matching","volume":"367","author":"K Helenius","year":"2019","journal-title":"BMJ"},{"issue":"08","key":"ref40","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3390\/cells9081871","article-title":"Preterm brain injury, antenatal triggers, and therapeutics: timing is key","volume":"9","author":"D RMG Ophelders","year":"2020","journal-title":"Cells"},{"issue":"02","key":"ref41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0095-5108(05)70022-1","article-title":"Antecedents of cerebral palsy in very low-birth weight infants","volume":"27","author":"T M O'Shea","year":"2000","journal-title":"Clin Perinatol"},{"issue":"01","key":"ref42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/uog.20417","article-title":"Impact of hypertension and preeclampsia intervention trial at near term-I (HYPITAT-I) on obstetric management and outcome in The Netherlands","volume":"55","author":"C MW de Sonnaville","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"04","key":"ref43","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jpeds.2009.10.018","article-title":"Maternal preeclampsia predicts the development of bronchopulmonary dysplasia","volume":"156","author":"A R Hansen","year":"2010","journal-title":"J Pediatr"},{"issue":"03","key":"ref44","doi-asserted-by":"crossref","first-page":"e20160689","DOI":"10.1542\/peds.2016-0689","article-title":"Reporting outcomes of extremely preterm births","volume":"138","author":"M A Rysavy","year":"2016","journal-title":"Pediatrics"},{"issue":"05","key":"ref45","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1542\/peds.105.5.1051","article-title":"A comparison of neonatal mortality risk prediction models in very low birth weight infants","volume":"105","author":"M M Pollack","year":"2000","journal-title":"Pediatrics"},{"issue":"06","key":"ref46","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/adc.2007.127316","article-title":"How much loss to follow-up is acceptable in long-term randomised trials and prospective studies?","volume":"93","author":"M S Fewtrell","year":"2008","journal-title":"Arch Dis Child"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jash.2014.09.005","article-title":"Maternal hypertensive pregnancy disorders and cognitive functioning of the offspring: a systematic review","volume":"8","author":"S Tuovinen","year":"2014","journal-title":"J Am Soc 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