{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:16:39Z","timestamp":1774685799988,"version":"3.50.1"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n            Objective\u2003This study was aimed to establish a reference interval for high-sensitivity cardiac troponin I (hs-cTnI) in umbilical cord blood of infants and to assess its association with the risk of predetermined early neonatal outcomes in a high-acuity tertiary care hospital.<\/jats:p><jats:p>\n            Study Design\u2003Umbilical cord-blood samples were collected and hs-cTnI was measured in all infants born between August 2015 and September 2015 at McMaster Children's Hospital (n\u2009=\u2009256). Gestational age, birth weight, Apgar's scores, age in days at which feeding was established, neonatal intensive care unit (NICU) admission, and discharge in days after birth were recorded.<\/jats:p><jats:p>\n            Results\u2003The 90th, 95th, and 99th percentiles for the term infant subcohort were 19.75, 41.45, and 166.30\u2009ng\/L, respectively. We observed decreased mean gestational ages and birth weights in both the 90th (37.7 weeks; 2,961.4\u2009g) and 95th percentiles (37.1 weeks; 2,709.9\u2009g) when compared with the remaining infants. Moreover, levels of hs-cTnI were significantly higher in infants with respiratory distress requiring intervention (p\u2009&lt;\u20090.05), low birth weight infants (p\u2009&lt;\u20090.01), preterm infants (p\u2009&lt;\u20090.001), and those requiring NICU admission (p\u2009&lt;\u20090.01). Multiple linear regression of the recorded demographic factors revealed prematurity (gestational age &lt;35 weeks: coefficient 0.346\u2009\u00b1\u20090.160, p\u2009&lt;\u20090.05; gestational age &lt;37 weeks: coefficient 0.253\u2009\u00b1\u20090.105, p\u2009&lt;\u20090.05) and male sex (coefficient 0.138\u2009\u00b1\u20090.047; p\u2009&lt;\u20090.01) to be most predictive of log-hs-cTnI levels.<\/jats:p><jats:p>\n            Conclusion\u2003This study establishes the reference values for cord-blood hs-cTnI in infants at a tertiary care center. Premature and sick infants requiring NICU admission had significantly higher levels of hs-cTnI.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1722944","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T21:45:27Z","timestamp":1612820727000},"page":"1548-1554","source":"Crossref","is-referenced-by-count":9,"title":["Cord-Blood High-Sensitivity Troponin-I Reference Interval and Association with Early Neonatal Outcomes"],"prefix":"10.1055","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7251-6725","authenticated-orcid":false,"given":"Paul M.","family":"Ryan","sequence":"first","affiliation":[{"name":"Brookfield School of Medicine and Health Sciences, University College Cork, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapas","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaaran","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Radovanovic","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Pugh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony K. C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada"},{"name":"Laboratory Medicine, Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,6]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/jmbi.2001.5118","article-title":"Ca(2+) induces an extended conformation of the inhibitory region of troponin I in cardiac muscle troponin","volume":"314","author":"W J Dong","year":"2001","journal-title":"J Mol 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