{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:30:33Z","timestamp":1772839833228,"version":"3.50.1"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Bronchial anastomotic complications are reported in 2 to 18% of patients after lung transplantation. The majority of complications can be managed with bronchoscopic intervention. When extensive dehiscence is present, surgical intervention can be entertained.<\/jats:p><jats:p>\n          Materials and Methods\u2003Between March 1, 2006, and December 31, 2019, our program performed 244 lung transplantations. We conducted a retrospective review of our patient cohort and identified patients who suffered from significant anastomotic complications that required surgical interventions.<\/jats:p><jats:p>\n          Results\u2003Twenty-eight and 216 patients underwent single and bilateral lung transplantations, respectively. Eighteen patients developed airway complications (7.4%). The incidence of anastomotic complications was 5.2% (24 complications for a total of 460 bronchial anastomoses). Four patients were managed conservatively. The majority of the bronchial anastomotic complications were managed endoscopically (eight patients). Four patients with associated massive air leak underwent repair of the bronchial anastomosis and two patients were retransplanted because they developed severe distal airway stenosis.<\/jats:p><jats:p>\n          Conclusion\u2003Bronchial anastomotic complications are a major cause of morbidity in lung transplantation. The majority of cases can be managed bronchoscopically. In more severe cases associated with massive air leak or imminent massive hemoptysis from bronchopulmonary arterial fistula, surgical intervention is necessary. Aortic homograft interposition along with vascularized pedicle wrapping may be a viable option to re-establish airway continuity when tension-free bronchial anastomotic revision is not possible. In cases with smaller bronchial defects, primary repair with utilization of a vascularized flap can be effective as treatment option.<\/jats:p>","DOI":"10.1055\/s-0041-1723002","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T05:18:55Z","timestamp":1613279935000},"page":"527-530","source":"Crossref","is-referenced-by-count":4,"title":["Repair of Bronchial Anastomosis Following Lung Transplantation"],"prefix":"10.1055","volume":"70","author":[{"given":"Themistokles","family":"Chamogeorgakis","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Surgery, Henry Ford Health System, Detroit, Michigan, United States"},{"name":"Onassis Cardiac Surgery Center, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Moquin","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Henry Ford Health System, Detroit, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Simoff","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Nemeh","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Surgery, Henry Ford Health System, Detroit, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ccm.2017.07.010","article-title":"Airway complications after lung transplantation","volume":"38","author":"L Frye","year":"2017","journal-title":"Clin Chest Med"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.athoracsur.2007.05.018","article-title":"Impact of anastomotic airway complications after lung transplantation","volume":"84","author":"S C Murthy","year":"2007","journal-title":"Ann Thorac Surg"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.thorsurg.2014.09.008","article-title":"Airway complications after lung transplantation","volume":"25","author":"M Machuzak","year":"2015","journal-title":"Thorac Surg Clin"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1067\/mtc.2001.110682","article-title":"Aortic homograft interposition for management of complete tracheal anastomotic disruption after heart-lung transplantation","volume":"121","author":"T M Hoffman","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.21037\/acs.2018.01.13","article-title":"Bioprosthetics and repair of complex aerodigestive defects","volume":"7","author":"B Udelsman","year":"2018","journal-title":"Ann Cardiothorac Surg"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jtcvs.2016.07.074","article-title":"Repair of large airway defects with bioprosthetic materials","volume":"152","author":"B V Udelsman","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.healun.2018.01.1309","article-title":"ISHLT consensus statement on adult and pediatric airway complications after lung transplantation: definitions, grading system, and therapeutics","volume":"37","author":"M M Crespo","year":"2018","journal-title":"J Heart Lung Transplant"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jtcvs.2019.12.119","article-title":"Single running suture technique is associated with low rate of bronchial complications after lung transplantation","volume":"160","author":"T Schweiger","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.athoracsur.2016.11.027","article-title":"In vivo tissue engineering of human airways","volume":"103","author":"E Martinod","year":"2017","journal-title":"Ann Thorac Surg"}],"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1723002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T23:10:47Z","timestamp":1663024247000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1723002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,12]]},"references-count":9,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2022,9,12]]},"published-print":{"date-parts":[[2022,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1723002","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,12]]}}}