{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T09:28:52Z","timestamp":1745918932177,"version":"3.37.3"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Since home confinement for novel coronavirus disease 2019 (COVID-19) pandemic began, pediatric visits to the emergency department (ED) have decreased, including consultation for abdominal pain. Our aim is to investigate the incidence of complicated acute appendicitis (AA; peritonitis or appendicular mass) during confinement for COVID-19 pandemic and to compare it with the previous 5 years.<\/jats:p><jats:p>\n          Materials and Methods\u2003A retrospective study was performed in children with AA who underwent surgery between March 9 and April 13 from 2015 to 2020; patients were divided into six groups according to the year of surgery. We analyzed demographic variables, time from onset of symptoms, mean hospital stay, cumulative incidence, and incidence rate of complicated appendicitis.<\/jats:p><jats:p>\n          Results\u2003A total of 168 patients were included with no differences in the number of patients, gender, and age between groups. Patients in 2020 (COVID-19 group) presented longer symptom progression time (46.8\u2009hours; p\u2009=\u20090.046), higher rate of complicated appendicitis (48.4%; p\u2009=\u20090.004), longer mean hospital stay (4.9 days; p\u2009&lt;\u20090.001), increased cumulative incidence (8.27 cases per 100,000 children per 0.1 years; p\u2009&lt;\u20090.001), and increased incidence rate of complicated appendicitis (83 cases per 100,000 children; p\u2009&lt;\u20090.001) when compared with other groups.<\/jats:p><jats:p>\n          Conclusion\u2003Delayed ED visit of children with AA during home confinement lead to an increased rate of complicated appendicitis. It is crucial to make parents aware of the importance of early diagnosis and treatment of abdominal pain.<\/jats:p>","DOI":"10.1055\/s-0041-1723992","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:07:50Z","timestamp":1614038870000},"page":"268-273","source":"Crossref","is-referenced-by-count":19,"title":["Complicated Acute Appendicitis during COVID-19 Pandemic: The Hidden Epidemic in Children"],"prefix":"10.1055","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-6898","authenticated-orcid":false,"given":"Carlos","family":"Delgado-Miguel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, La Paz Children's Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-9425","authenticated-orcid":false,"given":"Antonio J.","family":"Mu\u00f1oz-Serrano","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, La Paz Children's Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Miguel-Ferrero","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, La Paz Children's Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"De Ceano-Vivas","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, La Paz Children's Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Calvo","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Department, Fundaci\u00f3n IdiPaz. Traslational Research Network in Pediatric Infectious Diseases, Madrid. Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, La Paz Children's Hospital, Madrid, Spain"},{"name":"Institute for Biomedical Resarch La Paz (IdiPaz), Network for Maternal and Children Health (SAMID), La Paz Children's Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/jmv.25807","article-title":"COVID-19 epidemic: disease characteristics in children","volume":"92","author":"J She","year":"2020","journal-title":"J Med Virol"},{"issue":"17","key":"ref2","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1056\/NEJMc2005073","article-title":"SARS-CoV-2 infection in children","volume":"382","author":"X Lu","year":"2020","journal-title":"N Engl J Med"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/cid\/ciaa198","article-title":"A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features","volume":"71","author":"J Cai","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jinf.2020.02.018","article-title":"Characteristics of COVID-19 infection in Beijing","volume":"80","author":"S Tian","year":"2020","journal-title":"J Infect"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/ppul.24762","article-title":"Novel coronavirus infection in children outside of Wuhan, China","volume":"55","author":"Q Shen","year":"2020","journal-title":"Pediatr Pulmonol"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s13312-020-1819-5","article-title":"Coronavirus disease 2019 (COVID-19) in children - what we know so far and what we do not","volume":"57","author":"S Balasubramanian","year":"2020","journal-title":"Indian Pediatr"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/PHH.0000000000001190","article-title":"COVID-19 in children in the United States: intensive care admissions, estimated total infected, and projected numbers of severe pediatric cases in 2020","volume":"26","author":"E B Pathak","year":"2020","journal-title":"J Public Health Manag Pract"},{"issue":"13","key":"ref8","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1001\/jama.2020.2131","article-title":"Novel coronavirus infection in hospitalized infants under 1 year of age in China","volume":"323","author":"M Wei","year":"2020","journal-title":"JAMA"},{"issue":"04","key":"ref9","first-page":"269","article-title":"[Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China] (in Chinese)","volume":"58","author":"D Wang","year":"2020","journal-title":"Zhonghua Er Ke Za Zhi"},{"issue":"05","key":"ref11","doi-asserted-by":"publisher","first-page":"e261","DOI":"10.1016\/S2468-2667(20)30073-6","article-title":"The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study","volume":"5","author":"K Prem","year":"2020","journal-title":"Lancet Public Health"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"2000045","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045","article-title":"Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR","volume":"25","author":"V M Corman","year":"2020","journal-title":"Euro Surveill"},{"issue":"18","key":"ref15","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"W J Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.1346","article-title":"Screening and severity of coronavirus disease 2019 (COVID-19) in children in Madrid, Spain","author":"A Tagarro","year":"2020","journal-title":"JAMA Pediatr"},{"issue":"06","key":"ref17","first-page":"e20200702","article-title":"Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China","volume":"145","author":"Y Dong","year":"2020","journal-title":"Pediatrics"},{"issue":"05","key":"ref19","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1016\/S2352-4642(20)30108-5","article-title":"Delayed access or provision of care in Italy resulting from fear of COVID-19","volume":"4","author":"M Lazzerini","year":"2020","journal-title":"Lancet Child Adolesc Health"},{"issue":"04","key":"ref21","first-page":"185","article-title":"[Neutrophil-to-lymphocyte ratio as a predictor of peritonitis in acute appendicitis in children] (in Spanish)","volume":"32","author":"C Delgado-Miguel","year":"2019","journal-title":"Cir Pediatr"}],"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1723992.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T23:06:31Z","timestamp":1656543991000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1723992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":16,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2022,6,29]]},"published-print":{"date-parts":[[2022,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1723992","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"type":"print","value":"0939-7248"},{"type":"electronic","value":"1439-359X"}],"subject":[],"published":{"date-parts":[[2021,2,22]]}}}