{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:10:29Z","timestamp":1790208629951,"version":"4.1.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n            Objective\u2003Successful extubation and prevention of reintubation remain primary goals in neonatal ventilation. Our aim was to compare three modalities of postextubation respiratory support\u2014noninvasive positive pressure ventilation (NIPPV), nasal bilevel positive airway pressure (N-BiPAP), and nasal continuous positive airway pressure (NCPAP)\u2014using the RAM cannula in preterm neonates with respiratory distress syndrome (RDS). Our secondary aim was to define the predictors of successful extubation.<\/jats:p><jats:p>\n            Study Design\u2003A total of 120 preterm neonates (gestational age \u226435 weeks) with RDS who had undergone primary invasive ventilation were randomized to receive either NIPPV, N-BiPAP, or NCPAP. The incidence of respiratory failure in the first 48\u2009hours postextubation, total days of invasive and noninvasive ventilation, duration of hospitalization, and mortality were measured and compared among the three different noninvasive support modalities.<\/jats:p><jats:p>\n            Results\u2003There were no significant differences in the postextubation respiratory failure rates and the number of days of invasive as well as noninvasive ventilation among the three different support modalities (p &gt; 0.05). The total number of days of mechanical ventilation and the duration of hospitalization were significantly higher in the N-BiPAP group than those in the NCPAP or NIPPV groups (p\u2009&lt;\u20090.05). A gestational age of at least 29 weeks and a birth weight of at least 1.4\u2009kg were predictive of successful extubation with a sensitivity of 98.2 and 85.3% and a specificity of 63.6 and 90.9%, respectively.<\/jats:p><jats:p>\n            Conclusion\u2003Longer durations of mechanical ventilation and hospitalization were observed with N-BiPAP as a noninvasive mode of ventilation, but there was no significant difference in the extubation failure rates among the three modalities. Gestational age and birth weight were shown to be independent predictors of successful extubation of preterm neonates with RDS.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1723999","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:02:41Z","timestamp":1614124961000},"page":"1577-1585","source":"Crossref","is-referenced-by-count":11,"title":["Postextubation Noninvasive Ventilation in Respiratory Distress Syndrome: A Randomized Controlled Trial"],"prefix":"10.1055","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-6649","authenticated-orcid":false,"given":"Rania A.","family":"El-Farrash","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"DiBlasi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care, Seattle Children's Hospital and Research Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman A.","family":"AbdEL-Aziz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adham M.","family":"El-Tahry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Eladawy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad A.","family":"Tadros","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, Algalaa Gynecology and Children's Military Hospital, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Koriesh","sequence":"additional","affiliation":[{"name":"Getinge Group, Middle East, Dubai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Farid","sequence":"additional","affiliation":[{"name":"Ministry of Health, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riham S.","family":"AbdElwahab","sequence":"additional","affiliation":[{"name":"Ministry of Health, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medhat A.","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha M.","family":"Barakat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1055\/s-0034-1371702","article-title":"Impact of early extubation and reintubation on the incidence of bronchopulmonary dysplasia in neonates","volume":"31","author":"J Berger","year":"2014","journal-title":"Am J Perinatol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/ppul.22623","article-title":"Role of spontaneous breathing trial in predicting successful extubation in premature infants","volume":"48","author":"S Chawla","year":"2013","journal-title":"Pediatr Pulmonol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s40124-013-0032-6","article-title":"When and how to extubate premature infants from mechanical ventilation","volume":"2","author":"W 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Early nasal continuous positive airway pressure versus mechanical ventilation: gains and losses","volume":"419","author":"B J\u00f3nsson","year":"1997","journal-title":"Acta Paediatr Suppl"},{"issue":"03","key":"ref28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jpeds.2005.04.062","article-title":"Variables associated with the early failure of nasal CPAP in very low birth weight infants","volume":"147","author":"A Ammari","year":"2005","journal-title":"J Pediatr"},{"issue":"04","key":"ref29","first-page":"573","article-title":"Usefulness of DuoPAP in the treatment of very low birth weight preterm infants with neonatal respiratory distress syndrome","volume":"19","author":"B Zhou","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"02","key":"ref30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1542\/peds.2008-1302","article-title":"Synchronized nasal intermittent positive-pressure ventilation and neonatal outcomes","volume":"124","author":"V Bhandari","year":"2009","journal-title":"Pediatrics"},{"issue":"05","key":"ref31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/jpc.13175","article-title":"Nasal bi-level positive airway pressure (BiPAP) versus nasal continuous positive airway pressure (CPAP) in preterm infants \u226432\u2009weeks: a retrospective cohort study","volume":"52","author":"Z H Rong","year":"2016","journal-title":"J Paediatr Child Health"},{"issue":"03","key":"ref32","first-page":"221","article-title":"Nasal bilevel versus continuous positive airway pressure in preterm infants: a randomized controlled trial","volume":"5","author":"T Aguiar","year":"2015","journal-title":"J Clin Trials"},{"issue":"02","key":"ref33","first-page":"CD003212","article-title":"Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation","volume":"2","author":"B Lemyre","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"07","key":"ref34","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJMoa1214533","article-title":"A trial comparing noninvasive ventilation strategies in preterm infants","volume":"369","author":"H Kirpalani","year":"2013","journal-title":"N Engl J Med"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"508","DOI":"10.4187\/respcare.03560","article-title":"Evaluation of a nasal cannula in noninvasive ventilation using a lung simulator","volume":"60","author":"N P Iyer","year":"2015","journal-title":"Respir Care"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.4187\/respcare.05978","article-title":"Comparison of interfaces for the delivery of noninvasive respiratory support to low birthweight infants","volume":"63","author":"G S Drescher","year":"2018","journal-title":"Respir Care"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1723999.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:32:34Z","timestamp":1664494354000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1723999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":36,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2022,9,29]]},"published-print":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1723999","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]}}}