{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T20:57:15Z","timestamp":1785099435130,"version":"3.55.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003Avaliar o papel da concentra\u00e7\u00e3o s\u00e9rica de fosfatase alcalina (FA) e da ultrassonografia no monitoramento do progresso do tratamento da aus\u00eancia de consolida\u00e7\u00e3o em fraturas diafis\u00e1rias.<\/jats:p><jats:p>\n          M\u00e9todos\u2003Este estudo de coorte observacional prospectivo incluiu pacientes adultos com fraturas diafis\u00e1rias dos principais ossos longos previamente submetidas a fixa\u00e7\u00e3o interna sem consolida\u00e7\u00e3o. Ap\u00f3s o tratamento definitivo, os pacientes foram avaliados periodicamente por seis meses, com realiza\u00e7\u00e3o seriada de ultrassonografia, determina\u00e7\u00e3o da concentra\u00e7\u00e3o de FA e radiografias para verificar a presen\u00e7a de consolida\u00e7\u00e3o.<\/jats:p><jats:p>\n          Resultados\u2003Ap\u00f3s um aumento inicial em sete semanas, os n\u00edveis de FA voltaram ao valor normal em pacientes com fraturas consolidadas, mas continuaram elevados nos casos de aus\u00eancia de consolida\u00e7\u00e3o. Da mesma forma, ap\u00f3s uma eleva\u00e7\u00e3o do \u00edndice de resist\u00eancia (IR) vascular em cerca de 12 semanas em todos os pacientes, o IR diminuiu nos casos que progrediram para consolida\u00e7\u00e3o, mas continuou alto at\u00e9 as 24 semanas em fraturas n\u00e3o consolidadas. Os casos com aus\u00eancia de consolida\u00e7\u00e3o ainda apresentavam calo hipoecog\u00eanico \u00e0s 24 semanas, que n\u00e3o se converteu no calo hiperecog\u00eanico observado nos casos que progrediram para consolida\u00e7\u00e3o.<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003Altera\u00e7\u00f5es significativas sugestivas de consolida\u00e7\u00e3o foram simultaneamente observadas nas radiografias, na ultrassonografia e na concentra\u00e7\u00e3o de FA durante o per\u00edodo de acompanhamento. No entanto, a realiza\u00e7\u00e3o seriada de exames da concentra\u00e7\u00e3o de FA e de ultrassonografia durante o acompanhamento indicou o progresso da consolida\u00e7\u00e3o da fratura. Seu papel no monitoramento da aus\u00eancia de consolida\u00e7\u00e3o \u00e9 mais complementar do que suplementar \u00e0 radiografia.<\/jats:p>","DOI":"10.1055\/s-0041-1724072","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T23:54:32Z","timestamp":1638921272000},"page":"796-803","source":"Crossref","is-referenced-by-count":2,"title":["Monitoramento da evolu\u00e7\u00e3o do tratamento da aus\u00eancia de consolida\u00e7\u00e3o da fratura: Papel da fosfatase alcalina e da ultrassonografia"],"prefix":"10.1055","volume":"56","author":[{"given":"Dhanji S.","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia, Medical College Baroda e SSG Hospital, Vadodara, Gujarat, \u00cdndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayur J.","family":"Solanki","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia, Medical College Baroda e SSG Hospital, Vadodara, Gujarat, 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