{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:59:23Z","timestamp":1791932363560,"version":"4.3.4"},"reference-count":78,"publisher":"Elsevier BV","issue":"01","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Global Medical Genetics"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, it was found that proteomes from poliovirus, measles virus, dengue virus, and severe acute respiratory syndrome-related Coronavirus 2 (SARS-CoV-2) have high molecular mimicry at the heptapeptide level with the human proteome, while heptapeptide commonality is minimal or absent with proteomes from nonhuman primates, that is, gorilla, chimpanzee, and rhesus macaque. To acquire more data on the issue, analyses here have been expanded to Ebola virus, Francisella tularensis, human immunodeficiency virus-1 (HIV-1), Toxoplasma gondii, Variola virus, and Yersinia pestis. Results confirm that heptapeptide overlap is high between pathogens and Homo sapiens, but not between pathogens and primates. Data are discussed in light of the possible genetic bases that differently model primate phenomes, thus possibly underlying the zero\/low level of molecular mimicry between infectious agents and primates. Notably, this study might help address preclinical vaccine tests that currently utilize primates as animal models, since autoimmune cross-reactions and the consequent adverse events cannot occur in absentia of shared sequences.<\/jats:p>","DOI":"10.1055\/s-0041-1724106","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T14:00:35Z","timestamp":1613829635000},"page":"032-037","source":"Crossref","is-referenced-by-count":4,"title":["Lack of Molecular Mimicry between Nonhuman Primates and Infectious Pathogens: The Possible Genetic Bases"],"prefix":"10.1016","volume":"08","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2111-4608","authenticated-orcid":false,"given":"Darja","family":"Kanduc","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1046\/j.1440-1711.2000.00949.x","article-title":"Computer-assisted analysis of molecular mimicry between human papillomavirus 16 E7 oncoprotein and human protein sequences","volume":"78","author":"C Natale","year":"2000","journal-title":"Immunol Cell Biol"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.peptides.2008.05.022","article-title":"Massive peptide sharing between viral and human proteomes","volume":"29","author":"D Kanduc","year":"2008","journal-title":"Peptides"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4161\/self.1.4.13315","article-title":"No human protein is exempt from bacterial motifs, not even one","volume":"1","author":"B Trost","year":"2010","journal-title":"Self Nonself"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.autrev.2016.03.020","article-title":"Zika virus and autoimmunity: from microcephaly to Guillain-Barr\u00e9 syndrome, and beyond","volume":"15","author":"G Lucchese","year":"2016","journal-title":"Autoimmun Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1874226201808010016","article-title":"Inter-pathogen peptide sharing and the original antigenic sin: Solving a paradox","volume":"8","author":"D Kanduc","year":"2018","journal-title":"Open Immunol J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2741\/4133","article-title":"Confronting JC virus and Homo sapiens biological signatures","volume":"18","author":"G Lucchese","year":"2013","journal-title":"Front Biosci"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4161\/self.2.2.15795","article-title":"HCV: Written in our DNA","volume":"2","author":"D Kanduc","year":"2011","journal-title":"Self Nonself"},{"key":"ref8","first-page":"245","article-title":"Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes","volume":"4","author":"D Kanduc","year":"2010","journal-title":"Biologics"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1177\/039463200902200309","article-title":"Sequence uniqueness as a molecular signature of HIV-1-derived B-cell epitopes","volume":"22","author":"A Lucchese","year":"2009","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"E33","DOI":"10.3390\/antib9030033","article-title":"From anti-SARS-CoV-2 immune responses to COVID-19 via molecular mimicry","volume":"9","author":"D Kanduc","year":"2020","journal-title":"Antibodies (Basel)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.2741\/s341","article-title":"Peptide cross-reactivity: the original sin of vaccines","volume":"4","author":"D Kanduc","year":"2012","journal-title":"Front Biosci (Schol Ed)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2478\/ii-2019-0002","article-title":"From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity","volume":"7","author":"D Kanduc","year":"2019","journal-title":"Infect Int"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2174\/1871530314666140715115257","article-title":"Describing the potential crossreactome between mumps virus and spermatogenesis-associated proteins","volume":"14","author":"D Kanduc","year":"2014","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/schbul\/sbs197","article-title":"Peptide sharing between influenza A H1N1 hemagglutinin and human axon guidance proteins","volume":"40","author":"G Lucchese","year":"2014","journal-title":"Schizophr Bull"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fpsyt.2016.00060","article-title":"Understanding neuropsychiatric diseases, analyzing the peptide sharing between infectious agents and the language-associated NMDA 2A protein","volume":"7","author":"G Lucchese","year":"2016","journal-title":"Front Psychiatry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fpsyt.2017.00037","article-title":"From toxoplasmosis to schizophrenia via NMDA dysfunction: peptide overlap between Toxoplasma gondii and N-Methyl-d-Aspartate Receptors as a potential mechanistic link","volume":"8","author":"G Lucchese","year":"2017","journal-title":"Front Psychiatry"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2174\/1570163811666140212112300","article-title":"Single amino acid repeats connect viruses to neurodegeneration","volume":"11","author":"G Lucchese","year":"2014","journal-title":"Curr Drug Discov Technol"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1055\/s-0040-1715641","article-title":"From anti-EBV immune responses to the EBV diseasome via cross-reactivity","volume":"7","author":"D Kanduc","year":"2020","journal-title":"Glob Med Genet"},{"issue":"02","key":"ref19","first-page":"159","article-title":"Potential cross-reactivity between HPV16 L1 protein and sudden death-associated antigens","volume":"9","author":"D Kanduc","year":"2011","journal-title":"J Exp Ther Oncol"},{"issue":"08","key":"ref20","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2217\/fmb.13.72","article-title":"Peptide sharing between Bordetella pertussis proteome and human sudden death proteins: a hypothesis for a causal link","volume":"8","author":"G Capone","year":"2013","journal-title":"Future Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000502889","article-title":"Human papillomavirus epitope mimicry and autoimmunity: the molecular truth of peptide sharing","volume":"86","author":"D Kanduc","year":"2019","journal-title":"Pathobiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2478\/ii-2018-0023","article-title":"Influenza and sudden unexpected death: the possible role of peptide cross-reactivity","volume":"7","author":"D Kanduc","year":"2019","journal-title":"Infect Int"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"108426","DOI":"10.1016\/j.clim.2020.108426","article-title":"On the molecular determinants of the SARS-CoV-2 attack","volume":"215","author":"D Kanduc","year":"2020","journal-title":"Clin Immunol"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2217\/fmb.14.137","article-title":"Measles virus hemagglutinin epitopes are potential hotspots for crossreactions with immunodeficiency-related proteins","volume":"10","author":"D Kanduc","year":"2015","journal-title":"Future Microbiol"},{"key":"ref25","first-page":"14","article-title":"From viral infections to autistic neurodevelopmental disorders via cross-reactivity","volume":"3","author":"D Kanduc","year":"2018","journal-title":"J Psychiatry Brain Sci"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/BOR.0000000000000606","article-title":"From hepatitis C virus immunoproteomics to rheumatology via cross-reactivity in one table","volume":"31","author":"D Kanduc","year":"2019","journal-title":"Curr Opin Rheumatol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.12988\/asb.2020.91221","article-title":"Immunobiology: on the inexistence of a negative selection process","volume":"12","author":"D Kanduc","year":"2020","journal-title":"Adv Stud Biol"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000508903","article-title":"Hydrophobicity and the physico-chemical basis of immunotolerance","volume":"87","author":"D Kanduc","year":"2020","journal-title":"Pathobiology"},{"issue":"05","key":"ref29","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s12026-020-09152-6","article-title":"Molecular mimicry between SARS-CoV-2 spike glycoprotein and mammalian proteomes: implications for the vaccine","volume":"68","author":"D Kanduc","year":"2020","journal-title":"Immunol Res"},{"issue":"02","key":"ref30","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/s-0040-1716334","article-title":"Medical, genomic, and evolutionary aspects of the peptide sharing between pathogens, primates, and humans","volume":"7","author":"D Kanduc","year":"2020","journal-title":"Glob Med Genet"},{"key":"ref31","volume-title":"Nonhuman Primates in Biomedical Research","author":"C R Abee","year":"2012"},{"issue":"06","key":"ref32","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/sj.clpt.6100420","article-title":"Heterologous prime-boost strategy to immunize very young infants against measles: pre-clinical studies in rhesus macaques","volume":"82","author":"M F Pasetti","year":"2007","journal-title":"Clin Pharmacol Ther"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"e112568","DOI":"10.1371\/journal.pone.0112568","article-title":"Vaccine-induced protection of rhesus macaques against plasma viremia after intradermal infection with a European lineage 1 strain of West Nile virus","volume":"9","author":"B E Verstrepen","year":"2014","journal-title":"PLoS One"},{"issue":"06","key":"ref34","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1016\/S2352-3018(20)30001-1","article-title":"Comparison of shortened mosaic HIV-1 vaccine schedules: a randomised, double-blind, placebo-controlled phase 1 trial (IPCAVD010\/HPX1002) and a preclinical study in rhesus monkeys (NHP 17-22)","volume":"7","author":"K E Stephenson","year":"2020","journal-title":"Lancet HIV"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-020-2608-y","article-title":"ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques","volume":"586","author":"N van Doremalen","year":"2020","journal-title":"Nature"},{"issue":"01","key":"ref36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41392-020-00269-6","article-title":"Comparison of nonhuman primates identified the suitable model for COVID-19","volume":"5","author":"S Lu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-019-0105-9","article-title":"Plague vaccine: recent progress and prospects","author":"W Sun","year":"2019","journal-title":"npjVaccines"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nri2636","article-title":"Monkeying around with HIV vaccines: using rhesus macaques to define \u2018gatekeepers\u2019 for clinical trials","volume":"9","author":"D J Shedlock","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","author":"UniProt Consortium","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"21","key":"ref40","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1093\/bioinformatics\/btt484","article-title":"A fast Peptide Match service for UniProt Knowledgebase","volume":"29","author":"C Chen","year":"2013","journal-title":"Bioinformatics"},{"issue":"06","key":"ref41","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1093\/bioinformatics\/btz817","article-title":"Enzyme annotation in UniProtKB using Rhea","volume":"36","author":"A Morgat","year":"2020","journal-title":"Bioinformatics"},{"issue":"08","key":"ref42","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1101\/gr.10.8.1065","article-title":"A chimpanzee genome project is a biomedical imperative","volume":"10","author":"A Varki","year":"2000","journal-title":"Genome Res"},{"issue":"01","key":"ref43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrg981","article-title":"Sequencing the chimpanzee genome: insights into human evolution and disease","volume":"4","author":"M V Olson","year":"2003","journal-title":"Nat Rev Genet"},{"issue":"12","key":"ref44","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1101\/gr.3737405","article-title":"Comparing the human and chimpanzee genomes: searching for needles in a haystack","volume":"15","author":"A Varki","year":"2005","journal-title":"Genome Res"},{"key":"ref45","first-page":"1385","article-title":"Charting the peptide crossreactome between HIV-1 and the human proteome","volume":"3","author":"G Lucchese","year":"2011","journal-title":"Front Biosci (Elite Ed)"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0140-6736(18)31364-3","article-title":"Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1\/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)","volume":"392","author":"D H Barouch","year":"2018","journal-title":"Lancet"},{"issue":"08","key":"ref47","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nm0809-855","article-title":"Roadblocks in HIV research: five questions","volume":"15","author":"C Thomas","year":"2009","journal-title":"Nat Med"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb1480","article-title":"Another HIV vaccine strategy fails in large-scale study","author":"J Cohen","year":"2020","journal-title":"Science"},{"issue":"03","key":"ref49","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/infdis\/151.3.420","article-title":"Oral poliovirus vaccine: history of its development and use and current challenge to eliminate poliomyelitis from the world","volume":"151","author":"A B Sabin","year":"1985","journal-title":"J Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"151","DOI":"10.12691\/ijcd-3-4-8","article-title":"The world incidence and prevalence of autoimmune diseases is increasing","volume":"3","author":"A Lerner","year":"2015","journal-title":"Int J Celiac Dis"},{"issue":"51","key":"ref51","doi-asserted-by":"crossref","first-page":"7084","DOI":"10.1016\/j.vaccine.2017.10.088","article-title":"Q-Vax Q fever vaccine failures, Victoria, Australia 1994-2013","volume":"35","author":"K A Bond","year":"2017","journal-title":"Vaccine"},{"issue":"38","key":"ref52","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.15585\/mmwr.mm6438a7","article-title":"Measles outbreak associated with vaccine failure in adults-Federated States of Micronesia, February-August 2014","volume":"64","author":"L Breakwell","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"06","key":"ref53","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1542\/peds.2014-4118","article-title":"Epidemic pertussis and acellular pertussis vaccine failure in the 21st century","volume":"135","author":"J D Cherry","year":"2015","journal-title":"Pediatrics"},{"issue":"48","key":"ref54","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1016\/j.vaccine.2016.10.032","article-title":"Rotavirus, vaccine failure or diagnostic error?","volume":"34","author":"M Lopez-Lacort","year":"2016","journal-title":"Vaccine"},{"issue":"08","key":"ref55","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3201\/eid1908.121864","article-title":"Call to action for dengue vaccine failure","volume":"19","author":"S Mahalingam","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"bcr2014204714","DOI":"10.1136\/bcr-2014-204714","article-title":"Pneumococcal vaccine failure: can it be a primary immunodeficiency?","volume":"2014","author":"R Moinho","year":"2014","journal-title":"BMJ Case Rep"},{"issue":"11","key":"ref57","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.ebiom.2015.09.036","article-title":"Environmental enteropathy, oral vaccine failure and growth faltering in infants in Bangladesh","volume":"2","author":"C Naylor","year":"2015","journal-title":"EBioMedicine"},{"issue":"06","key":"ref58","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/14760584.2018.1484284","article-title":"Influenza vaccine failure: failure to protect or failure to understand?","volume":"17","author":"G A Poland","year":"2018","journal-title":"Expert Rev Vaccines"},{"issue":"02","key":"ref59","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1071\/HC13092","article-title":"The public health implications of secondary measles vaccine failure","volume":"5","author":"M Ramsay","year":"2013","journal-title":"J Prim Health Care"},{"issue":"01","key":"ref60","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/21645515.2015.1093263","article-title":"Primary vaccine failure to routine vaccines: why and what to do?","volume":"12","author":"U Wiedermann","year":"2016","journal-title":"Hum Vaccin Immunother"},{"issue":"02","key":"ref61","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S1472-6483(10)61702-6","article-title":"Are the universes of antibodies and antigens symmetrical?","volume":"6","author":"G Pieczenik","year":"2003","journal-title":"Reprod Biomed Online"},{"issue":"02","key":"ref62","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2174\/1389203711314020003","article-title":"Pentapeptides as minimal functional units in cell biology and immunology","volume":"14","author":"D Kanduc","year":"2013","journal-title":"Curr Protein Pept Sci"},{"issue":"06","key":"ref63","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ygeno.2005.07.009","article-title":"Comparative genomic analysis of human and chimpanzee proteases","volume":"86","author":"X S Puente","year":"2005","journal-title":"Genomics"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.gene.2004.11.003","article-title":"Eighty percent of proteins are different between humans and chimpanzees","volume":"346","author":"G Glazko","year":"2005","journal-title":"Gene"},{"issue":"01","key":"ref65","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1086\/431652","article-title":"Segmental duplications and copy-number variation in the human genome","volume":"77","author":"A J Sharp","year":"2005","journal-title":"Am J Hum Genet"},{"issue":"03","key":"ref66","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1534\/genetics.107.080077","article-title":"Accelerated rate of gene gain and loss in primates","volume":"177","author":"M W Hahn","year":"2007","journal-title":"Genetics"},{"issue":"09","key":"ref67","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1101\/gr.6557307","article-title":"Gene copy number variation spanning 60 million years of human and primate evolution","volume":"17","author":"L Dumas","year":"2007","journal-title":"Genome Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nature07744","article-title":"A burst of segmental duplications in the genome of the African great ape ancestor","volume":"457","author":"T Marques-Bonet","year":"2009","journal-title":"Nature"},{"issue":"02","key":"ref69","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1534\/genetics.108.099960","article-title":"Segmental duplications contribute to gene expression differences between humans and chimpanzees","volume":"182","author":"R Blekhman","year":"2009","journal-title":"Genetics"},{"issue":"01","key":"ref70","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/evo.12819","article-title":"The evolution of gene expression and binding specificity of the largest transcription factor family in primates","volume":"70","author":"A Kapopoulou","year":"2016","journal-title":"Evolution"},{"issue":"05","key":"ref71","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1101\/gr.4843906","article-title":"Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes","volume":"16","author":"A T Hamilton","year":"2006","journal-title":"Genome Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1126\/science.1108296","article-title":"Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees","volume":"309","author":"P Khaitovich","year":"2005","journal-title":"Science"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1126\/science.1068996","article-title":"Intra- and interspecific variation in primate gene expression patterns","volume":"296","author":"W Enard","year":"2002","journal-title":"Science"},{"issue":"28","key":"ref74","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.2174\/138161209789105135","article-title":"\u201cSelf-nonself\u201d peptides in the design of vaccines","volume":"15","author":"D Kanduc","year":"2009","journal-title":"Curr Pharm Des"},{"issue":"03","key":"ref75","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4161\/self.1.3.11897","article-title":"The self\/nonself issue: a confrontation between proteomes","volume":"1","author":"D Kanduc","year":"2010","journal-title":"Self Nonself"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"832341","DOI":"10.1155\/2010\/832341","article-title":"Proposing low-similarity peptide vaccines against Mycobacterium tuberculosis","volume":"2010","author":"G Lucchese","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1479-5876-4-43","article-title":"Preliminary data on Pemphigus vulgaris treatment by a proteomics-defined peptide: a case report","volume":"4","author":"G Angelini","year":"2006","journal-title":"J Transl Med"},{"issue":"10","key":"ref78","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.2174\/1871520615666150716105543","article-title":"Immunogenicity, immunopathogenicity, and immunotolerance in one graph","volume":"15","author":"D Kanduc","year":"2015","journal-title":"Anticancer Agents Med Chem"}],"container-title":["Global Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1724106.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T15:22:30Z","timestamp":1736436150000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1724106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,19]]},"references-count":78,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2021,3,16]]},"published-print":{"date-parts":[[2021,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1724106","relation":{},"ISSN":["2699-9404"],"issn-type":[{"value":"2699-9404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,19]]}}}