{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:44:49Z","timestamp":1790304289935,"version":"4.1.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Injectable fillers represent one of the most requested minimally invasive treatments to rejuvenate the aging face, and its popularity is steadily rising. A vast majority of filler treatments are with hyaluronic acid (HA). The aim of this systematic review is to evaluate patient outcomes, safety profile, and administration techniques of various HA fillers for malar augmentation. A systematic review of the published literature was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and included PubMed, Embase, and Science Direct databases. Medical Subject Headings (MeSH) terms used were \u201ccheek\u201d OR \u201cmidface\u201d OR \u201cmalar\u201d and \u201cfiller\u201d OR \u201chyaluronic acid\u201d OR \u201cJuvederm\u201d OR \u201cRestylane\u201d OR \u201cPerlane\u201d OR \u201cBelotero.\u201d The initial search identified 699 articles; 256 duplicates were removed. Additional 12 studies were identified from reference lists. A total of 455 were screened by title and abstract and 387 studies were eliminated based on criteria. Also, 68 articles underwent full-text review, and 18 articles were included in the final review and involved seven different HA formulations. Men and women from many age groups were highly satisfied with their results following HA treatment for midface augmentation up to 24 months. The most common adverse events included bruising, swelling, and tenderness, and typically lasted no more than 2 weeks. Upper cheek filler injections near the zygoma should be placed in the submuscular plane while lower cheek injections should be placed in the subcutaneous tissue. HA is an attractive choice for midface augmentation due to its high patient satisfaction, long-lasting effects, and low side-effect profile. Due to the variability in technique, level of expertise, and subjective measurements across studies, one optimal regimen could not be concluded. However, midface augmentation treatment should be personalized to each patient. Additional clinical trials are required to more conclusively determine the most appropriate approach for this procedure.<\/jats:p>","DOI":"10.1055\/s-0041-1724122","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T01:17:48Z","timestamp":1614302268000},"page":"576-584","source":"Crossref","is-referenced-by-count":33,"title":["Hyaluronic Acid Fillers for Midface Augmentation: A Systematic Review"],"prefix":"10.1055","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8534-6630","authenticated-orcid":false,"given":"Lily N.","family":"Trinh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, School of Medicine, Tulane University, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Surgery, St. Elizabeth's Medical Center, Brighton, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.asj.2005.09.012","article-title":"The anatomy of the aging face: volume loss and changes in 3-dimensional topography","volume":"26","author":"S R Coleman","year":"2006","journal-title":"Aesthet Surg J"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"388","DOI":"10.5114\/pdia.2014.40981","article-title":"Volumetric techniques: three-dimensional midface modeling","volume":"31","author":"A Macierzy\u0144ska","year":"2014","journal-title":"Postepy Dermatol Alergol"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cps.2014.08.002","article-title":"An algorithmic approach to multimodality midfacial rejuvenation using a new classification system for midfacial aging","volume":"42","author":"A A Jacono","year":"2015","journal-title":"Clin Plast Surg"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00006534-200201000-00052","article-title":"Three-dimensional endoscopic midface enhancement: a personal quest for the ideal cheek rejuvenation","volume":"109","author":"O M Ramirez","year":"2002","journal-title":"Plast Reconstr Surg"},{"key":"ref7","first-page":"205","volume-title":"The \u201cOgee\u201d of the midface: aesthetic and technical considerations","author":"O Ramirez","year":"2012"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/asj\/sjx122","article-title":"Quantification of the aesthetically desirable female midface position","volume":"38","author":"G Linkov","year":"2018","journal-title":"Aesthet Surg J"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1055\/s-0035-1544924","article-title":"Injectable fillers: review of material and properties","volume":"31","author":"N H Attenello","year":"2015","journal-title":"Facial Plast Surg"},{"key":"ref10","volume-title":"Soft Tissue Augmentation. Procedures in Cosmetic Dermatology Series","author":"A Carruthers","year":"2012","edition":"3rd ed."},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.fsc.2015.07.006","article-title":"Facial filler complications","volume":"23","author":"J Woodward","year":"2015","journal-title":"Facial Plast Surg Clin North Am"},{"issue":"09","key":"ref12","first-page":"1077","article-title":"Cheek augmentation improves feelings of facial attractiveness","volume":"11","author":"A F Taub","year":"2012","journal-title":"J Drugs Dermatol"},{"issue":"09","key":"ref13","first-page":"943","article-title":"Effect of midfacial volume augmentation with non animal stabilized hyaluronic acid on the nasolabial fold and global aethestic appearance","volume":"14","author":"B S Biesman","year":"2015","journal-title":"J Drugs Dermatol"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/dsu.12340","article-title":"Safety and 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