{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:44:35Z","timestamp":1791477875103,"version":"4.3.4"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin B12 is a water-soluble vitamin that plays a fundamental role as an essential cofactor for two enzymes responsible for the production of succinyl-CoA and methionine. Vitamin B12 deficiency can occur in infants and may be related to the breastfeeding mother's adherence to a vegan diet or somatic diseases in the mother. It should be differentiated from inborn errors of vitamin B12 metabolism. Herein, we report the cases of three infants with West syndrome; all three were breastfed by mothers who followed a strict vegan diet. In one of the three infants, West syndrome developed during treatment with vitamin B12 and normalization of the vitamin B12 level. Early treatment and replacement therapy are worthwhile to prevent serious neurological problems and to improve the patient's clinical course.<\/jats:p>","DOI":"10.1055\/s-0041-1725013","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T23:40:14Z","timestamp":1614814814000},"page":"333-336","source":"Crossref","is-referenced-by-count":11,"title":["Vitamin B12 Deficiency and West Syndrome: An Uncommon but Preventable Cause of Neurological Disorder. Report on Three Cases, One of Them with Late Onset during Vitamin B12 Treatment"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-9560","authenticated-orcid":false,"given":"Piero","family":"Pavone","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sullo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Falsaperla","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care, AUO San Marco-Policlinico, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Crespo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de Pediatr\u00eda \u201cProf. Dr. Juan P Garrahan\u201d Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de Pediatr\u00eda \u201cProf. Dr. Juan P Garrahan\u201d Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Caraballo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de Pediatr\u00eda \u201cProf. Dr. Juan P Garrahan\u201d Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1007\/s10072-020-04600-5","article-title":"West syndrome: a comprehensive review","volume":"41","author":"P Pavone","year":"2020","journal-title":"Neurol Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jpeds.2019.07.052","article-title":"Newborn screening for vitamin B12 deficiency in Germany-strategies, results, and public health implications","volume":"216","author":"G Gramer","year":"2020","journal-title":"J Pediatr"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/apa.13625","article-title":"B12 deficiency is common in infants and is accompanied by serious neurological 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A case report and review of literature","volume":"37","author":"K Glaser","year":"2015","journal-title":"Brain Dev"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3389\/fped.2019.00531","article-title":"West syndrome in an infant with vitamin B12 deficiency born to autoantibodies positive mother","volume":"7","author":"P F Chong","year":"2019","journal-title":"Front Pediatr"},{"issue":"04","key":"ref17","first-page":"157","article-title":"[Maternal vitamin B12 deficiency: cause for neurological symptoms in infancy]","volume":"211","author":"T L\u00fccke","year":"2007","journal-title":"Z Geburtshilfe Neonatol"}],"container-title":["Neuropediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1725013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T22:58:33Z","timestamp":1626303513000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1725013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":17,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2021,7,14]]},"published-print":{"date-parts":[[2021,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1725013","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0174-304X","1439-1899"],"issn-type":[{"value":"0174-304X","type":"print"},{"value":"1439-1899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]}}}