{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:27:00Z","timestamp":1776317220752,"version":"3.50.1"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>\n            Objective\u2003Infants with a history of neonatal hypoxic-ischemic encephalopathy (HIE) are at risk for oral motor dysfunction. Previous studies have associated the need for gastrostomy tube at neonatal intensive care unit discharge with brainstem injury on magnetic resonance imaging (MRI). However, the factors associated with time to full oral feeds in this population have not been previously described. This study aimed to study factors associated with time to full oral feeds in this population.<\/jats:p><jats:p>\n            Study Design\u2003This is a single-center, retrospective study that examined these factors using Cox regression.<\/jats:p><jats:p>\n            Results\u2003A total of 150 infants who received therapeutic hypothermia from 2011 to 2017 were included in this study. The single clinical factor significantly associated with time to full oral feeds was the severity of background abnormality on electroencephalogram in the first 24\u2009hours of age (severe vs. mild 95% confidence interval [CI]: 0.34\u20130.74; moderate vs. mild 95% CI: 0.19\u20130.45). Brainstem injury on MRI was the factor most highly associated with need for gastrostomy tube placement (p\u2009=\u20090.028), though the overall incidence of need for gastrostomy tube feeds in this population was low (5%).<\/jats:p><jats:p>\n            Conclusion\u2003These findings may help clinicians counsel families on what to expect in neonates with HIE and make decisions on the need for and timing to pursue gastrostomy tube in this population.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1725161","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T23:42:19Z","timestamp":1614814939000},"page":"1678-1681","source":"Crossref","is-referenced-by-count":7,"title":["Electroencephalogram Background Predicts Time to Full Oral Feedings in Hypoxic\u2013Ischemic Encephalopathy"],"prefix":"10.1055","volume":"39","author":[{"given":"Mrinmayee","family":"Takle","sequence":"additional","affiliation":[{"name":"Children's National Hospital Child Neurology Residency Program, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Conaway","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1902-1499","authenticated-orcid":false,"given":"Jennifer","family":"Burnsed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia, Charlottesville, Virginia"},{"name":"Department of Neurology, University of Virginia, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"F260","DOI":"10.1136\/adc.2008.146977","article-title":"Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial","volume":"94","author":"D Azzopardi","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3174\/ajnr.A2103","article-title":"Dorsal brain stem syndrome: MR imaging location of brain stem tegmental lesions in neonates with oral motor dysfunction","volume":"31","author":"C C Quattrocchi","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.ejpn.2012.05.001","article-title":"Feeding and communication impairments in infants with central grey matter lesions following perinatal hypoxic-ischaemic injury","volume":"16","author":"M Martinez-Biarge","year":"2012","journal-title":"Eur J Paediatr Neurol"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/jp.2013.1","article-title":"Does clinical status 1 week after therapeutic hypothermia predict brain MRI abnormalities?","volume":"33","author":"S Sarkar","year":"2013","journal-title":"J Perinatol"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41372-018-0080-4","article-title":"Predicting the need for home gavage or g-tube feeds in asphyxiated neonates treated with therapeutic hypothermia","volume":"38","author":"S Gupta","year":"2018","journal-title":"J Perinatol"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/sj.jp.7211896","article-title":"Implementation of a \u2018Hypothermia for HIE\u2019 program: 2-year experience in a single NICU","volume":"28","author":"S A Zanelli","year":"2008","journal-title":"J Perinatol"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4329\/wjr.v8.i2.117","article-title":"Brainstem tegmental lesions in neonates with hypoxic-ischemic encephalopathy: magnetic resonance diagnosis and clinical outcome","volume":"8","author":"C C Quattrocchi","year":"2016","journal-title":"World J Radiol"},{"issue":"15","key":"ref8","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"S Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2431-8-17","article-title":"The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial","volume":"8","author":"D Azzopardi","year":"2008","journal-title":"BMC Pediatr"},{"issue":"08","key":"ref10","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/archpediatrics.2011.43","article-title":"Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial","volume":"165","author":"S E Jacobs","year":"2011","journal-title":"Arch Pediatr Adolesc Med"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1725161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:31:47Z","timestamp":1667953907000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1725161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":10,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2022,11,8]]},"published-print":{"date-parts":[[2022,11]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1725161","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]}}}