{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:40:49Z","timestamp":1768783249263,"version":"3.49.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"NIH","award":["U34 5U34HL114988"],"award-info":[{"award-number":["U34 5U34HL114988"]}]},{"name":"U.S. Department of Health and Human Services (HHS), Maternal Child Health Bureau","award":["2H30MC24049"],"award-info":[{"award-number":["2H30MC24049"]}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["CDT-142654"],"award-info":[{"award-number":["CDT-142654"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003There is need for validated outcome measures for postthrombotic syndrome (PTS) following pediatric venous thromboembolism (VTE), with a focus on quality of life (QoL).<\/jats:p><jats:p>\n          Aims\u2003This article assesses reliability and validity of two PTS and two QoL scales for children following lower extremity VTE.<\/jats:p><jats:p>\n          Methods\u2003Pediatric patients following lower extremity VTE were recruited from three thrombosis clinics. The Manco\u2013Johnson (MJ) and the modified Villalta (MV) PTS scales were compared with each other and with the generic pediatric health-related QoL, PedsQL, and a newly developed pediatric venous-specific QoL, the Peds-VEINES-QOL.<\/jats:p><jats:p>\n          Results\u2003Eighty children following VTE and 60 healthy control children were enrolled. Internal consistency measured by Cronbach's \u03b1 was high for the two QoL scales, and moderate for the two PTS scales. Inter-rater reliability using intraclass correlation coefficients was moderate to high for the MJ, MV, and Peds-VEINES-QOL, and moderate for the PedsQL. Evidence of high internal consistency by Cronbach's \u03b1 coefficients, and moderate to high interitem correlations support the premise that a single construct was measured by each instrument. Correlations between the four instruments indicate convergent validity.<\/jats:p><jats:p>\n          Conclusion\u2003The MJ and MV scales detect similar outcomes in children following VTE. As used, the MJ is slightly more sensitive to QoL because a positive diagnosis requires pain which is the leading factor in reduced QoL following deep vein thrombosis. When using the MV, a requirement for pain or abnormal use to diagnose PTS would make the MV a better predictor of QoL.<\/jats:p>","DOI":"10.1055\/s-0041-1725199","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:08:45Z","timestamp":1615507725000},"page":"1367-1375","source":"Crossref","is-referenced-by-count":5,"title":["Validation of Outcome Instruments for Pediatric Postthrombotic Syndrome: Introducing the Peds-VEINES-QOL, a New Health-Related Quality of Life Instrument"],"prefix":"10.1055","volume":"121","author":[{"given":"Julie","family":"Smith","sequence":"additional","affiliation":[{"name":"Hemophilia and Thrombosis Center, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Thornhill","sequence":"additional","affiliation":[{"name":"Hemophilia and Thrombosis Center, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil A.","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States"},{"name":"Johns Hopkins All Children's Institute for Clinical and Translational Research, St. Petersburg, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-4530","authenticated-orcid":false,"given":"Leonardo","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children (SickKids), University of Toronto, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda","family":"Knapp-Clevenger","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, School of Nursing, University of Rochester, Rochester, New York, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth Boulden","family":"Warren","sequence":"additional","affiliation":[{"name":"Hemophilia and Thrombosis Center, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children (SickKids), University of Toronto, Toronto, Canada"},{"name":"Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan R.","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lady Davis Institute, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Manco-Johnson","sequence":"additional","affiliation":[{"name":"Hemophilia and Thrombosis Center, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1538-7836.2011.04594.x","article-title":"Definition of post-thrombotic syndrome following lower extremity deep venous thrombosis and standardization of outcome measurement in pediatric clinical investigations","volume":"10","author":"N A Goldenberg","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2146\/ajhp110241","article-title":"Quality of life and economic 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