{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T05:42:02Z","timestamp":1759383722750,"version":"3.37.3"},"reference-count":102,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Philosophical\u2013scientific correlations described in previous studies suggest that the genome can be the biological representation of the vital force, whilst the disease-promoting epigenetic alterations would be the biological representation of the chronic miasmas. In this study, we expand the functional correlation between vital force and chromosomes, describing the mechanism of action of the telomere\u2013telomerase complex in the context of physiological balance.<\/jats:p><jats:p>\n          Aims\u2003The aim of the work is to study the role of the telomere\u2013telomerase complex in cell vitality, biological aging, and the health-disease process, with the goal of proposing the use of telomere length as a biomarker of the vital force state and the effectiveness of homeopathic treatment.<\/jats:p><jats:p>\n          Results\u2003Similar to the vital force, telomere length and telomerase enzyme activity play an important role in maintaining cellular vitality, biological longevity, and physiological homeostasis. Telomere shortening functions as a biomarker of vital imbalance and is associated with numerous diseases and health disorders. On the other hand, health-promotion practices neutralize the pathological shortening of the telomeres, acting therapeutically in diseases or age-dependent health disorders.<\/jats:p><jats:p>\n          Conclusions\u2003As a hypothetical biomarker of the vital force state, an intra-individual analysis of the mean leukocyte telomere length before, during, and after homeopathic treatment can be used as a biomarker of therapeutic effectiveness.<\/jats:p>","DOI":"10.1055\/s-0041-1726008","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T23:35:03Z","timestamp":1621294503000},"page":"283-291","source":"Crossref","is-referenced-by-count":4,"title":["Telomere and Telomerase: Biological Markers of Organic Vital Force State and Homeopathic Treatment Effectiveness"],"prefix":"10.1055","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3338-8588","authenticated-orcid":false,"given":"Marcus Zulian","family":"Teixeira","sequence":"additional","affiliation":[{"name":"School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1055\/s-0038-1676810","article-title":"Isopathic use of auto-sarcode of DNA as anti-miasmatic homeopathic medicine and modulator of gene expression?","volume":"108","author":"M Z Teixeira","year":"2019","journal-title":"Homeopathy"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1055\/s-0039-1692162","article-title":"Correlation between vitalism and genetics according to the paradigm of complexity","volume":"109","author":"M Z Teixeira","year":"2020","journal-title":"Homeopathy"},{"key":"ref3","first-page":"39","article-title":"A concep\u00e7\u00e3o vitalista de Samuel Hahnemann","volume":"61","author":"M Z Teixeira","year":"1996","journal-title":"Rev Homeopatia (S\u00e3o Paulo)"},{"key":"ref5","volume-title":"Organon der Heilkunst. 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