{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T23:01:59Z","timestamp":1744758119466,"version":"3.37.3"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Combination of chronic inflammation and an altered tissue remodeling process are involved in the development of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Studies demonstrated that mesenchymal stem cells expressing the progenitor gene CD133 were involved in a significant reduction of the chronic inflammatory process in the polypoid tissue.<\/jats:p><jats:p>\n          Objective\u2003To evaluate the levels of CD133 (Prominin-1) in nasal polypoid tissue and its correlation with interleukin-8 (IL-8) and transforming growth factor \u03b21 (TGF-\u03b21).<\/jats:p><jats:p>\n          Methods\u2003A total of 74 subjects were divided in the following groups: control group (n\u2009=\u200935); chronic rhinosinusitis with nasal polyps nonpresenting comorbid asthma and aspirin intolerance (CRSwNPnonAI) group (n\u2009=\u200927); and chronic rhinosinusitis with nasal polyps presenting comorbid asthma and aspirin intolerance (CRSwNPAI) group (n\u2009=\u200912). Histologic analysis and also evaluation of the concentration of CD133, IL-8, and TGF-\u03b21 by enzyme-linked immunosorbent assay (ELISA) kits were performed in nasal tissue obtained from nasal polypectomy or from middle turbinate tissue.<\/jats:p><jats:p>\n          Results\u2003Higher eosinophilic infiltration was found in both CRSwNP groups by histologic analysis. Lower levels of TGF-\u03b21 and IL-8 were observed in both CRSwNP groups when compared with the control group, whereas the CD133 levels were significantly reduced only in the CRSwNPnonAI group compared with the control group.<\/jats:p><jats:p>\n          Conclusion\u2003It was demonstrated that the nasal mucosa presenting polyposis showed a significant reduction of CD133 levels, and also that this reduction was significantly correlated with the reduction of TGF-\u03b21 levels, but not with IL-8 levels. Therefore, these findings may be involved in the altered inflammatory and remodeling processes observed in the nasal polyposis.<\/jats:p>","DOI":"10.1055\/s-0041-1726043","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T22:39:06Z","timestamp":1624660746000},"page":"e091-e096","source":"Crossref","is-referenced-by-count":2,"title":["CD133, a Progenitor Cell Marker, is Reduced in Nasal Polyposis and Showed Significant Correlations with TGF-\u03b21 and IL-8"],"prefix":"10.1055","volume":"26","author":[{"given":"Wagner Vargas Souza","family":"Lino","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Luis Lacerda","family":"Bachi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"},{"name":"Instituto Brasileiro Ensino\/Pesquisa em Imunologia Pulmonar, S\u00e3o Paulo, SP, Brazil"},{"name":"Postgraduation Program in Health Science, Universidade Santo Amaro), Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Arruda Mendes","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Caetani","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Gafree e Guinle, Universidade Federal do Estado do Rio de Janeiro,, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5819-0474","authenticated-orcid":false,"given":"J\u00f4natas Bussador do","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio","family":"Pezato","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"},{"name":"Hospital Universit\u00e1rio Gafree e Guinle, Universidade Federal do Estado do Rio de Janeiro,, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/cea.12472","article-title":"Pathogenesis of nasal polyposis","volume":"45","author":"K E Hulse","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4193\/Rhin20.600","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"W J Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"03","key":"ref3","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.anl.2018.09.004","article-title":"JESREC score and mucosal eosinophilia can predict endotypes of chronic rhinosinusitis with nasal polyps","volume":"46","author":"T Nakayama","year":"2019","journal-title":"Auris Nasus Larynx"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.5415\/apallergy.2017.7.3.121","article-title":"Classification of chronic rhinosinusitis according to a nasal polyp and tissue eosinophilia: limitation of current classification system for Asian population","volume":"7","author":"S-W Cho","year":"2017","journal-title":"Asia Pac Allergy"},{"issue":"08","key":"ref5","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"T Tokunaga","year":"2015","journal-title":"Allergy"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"W J Fokkens","year":"2012","journal-title":"Rhinology"},{"issue":"02","key":"ref7","doi-asserted-by":"publisher","first-page":"162","DOI":"10.4193\/Rhin13.066","article-title":"Mechanical disfunction in the mucosal oedema formation of patients with nasal polyps","volume":"52","author":"R Pezato","year":"2014","journal-title":"Rhinology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1916-0216-42-27","article-title":"Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling","volume":"42","author":"R Pezato","year":"2013","journal-title":"J Otolaryngol Head Neck Surg"},{"issue":"06","key":"ref9","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1016\/j.jaci.2015.10.009","article-title":"Chronic rhinosinusitis pathogenesis","volume":"136","author":"W W Stevens","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"03","key":"ref10","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1002\/lary.26391","article-title":"Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis","volume":"127","author":"A S DeConde","year":"2017","journal-title":"Laryngoscope"},{"issue":"04","key":"ref11","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.amjoto.2018.03.020","article-title":"Nasal polyposis pathophysiology: Endotype and phenotype open issues","volume":"39","author":"G Brescia","year":"2018","journal-title":"Am J Otolaryngol"},{"issue":"02","key":"ref12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1055\/s-0036-1593728","article-title":"Fibrotic Tissue and Middle Turbinate Exhibit Similar Mechanical Properties. Is Fibrosis a Solution in Nasal Polyposis?","volume":"21","author":"L Greg\u00f3rio","year":"2017","journal-title":"Int Arch Otorhinolaryngol"},{"issue":"02","key":"ref13","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1055\/s-0038-1676095","article-title":"What is the Impact of Positive Airway Pressure in Nasal Polyposis? An Experimental Study","volume":"23","author":"L Balsalobre","year":"2019","journal-title":"Int Arch Otorhinolaryngol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"583409","DOI":"10.1155\/2014\/583409","article-title":"Immunoregulatory effects of bone marrow-derived mesenchymal stem cells in the nasal polyp microenvironment","volume":"2014","author":"R Pezato","year":"2014","journal-title":"Mediators Inflamm"},{"key":"ref15","first-page":"1","volume-title":"Hypotheses about the Potential Role of Mesenchymal Stem Cell on Nasal Polyposis: A Soft Inflamed Tissue Suffering from Mechanical Dysfunction","author":"R Pezato","year":"2016"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fimmu.2017.00039","article-title":"Nasal Polyp-Derived Mesenchymal Stromal Cells Exhibit Lack of Immune-Associated Molecules and High Levels of Stem\/Progenitor Cells Markers","volume":"8","author":"P WB de Oliveira","year":"2017","journal-title":"Front Immunol"},{"issue":"12","key":"ref17","doi-asserted-by":"publisher","first-page":"5013","DOI":"10.1182\/blood.V90.12.5013","article-title":"A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning","volume":"90","author":"S Miraglia","year":"1997","journal-title":"Blood"},{"issue":"01","key":"ref18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/2162-3619-2-17","article-title":"CD133: a stem cell biomarker and beyond","volume":"2","author":"Z Li","year":"2013","journal-title":"Exp Hematol Oncol"},{"issue":"05","key":"ref19","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1002\/hep.23544","article-title":"Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-\u03b2","volume":"51","author":"H You","year":"2010","journal-title":"Hepatology"},{"issue":"01","key":"ref20","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/onc.2010.383","article-title":"CD133 suppresses neuroblastoma cell differentiation via signal pathway modification","volume":"30","author":"H Takenobu","year":"2011","journal-title":"Oncogene"},{"issue":"09","key":"ref21","doi-asserted-by":"publisher","first-page":"4010","DOI":"10.1158\/0008-5472.can-06-4180","article-title":"CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles","volume":"67","author":"D Beier","year":"2007","journal-title":"Cancer Res"},{"issue":"10","key":"ref22","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1002\/ijc.28263","article-title":"CD133 expression in circulating tumor cells from breast cancer patients: potential role in resistance to chemotherapy","volume":"133","author":"R Nadal","year":"2013","journal-title":"Int J Cancer"},{"issue":"05","key":"ref23","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00005-017-0456-8","article-title":"Neuronal Differentiation Capability of Nasal Polyps of Chronic Rhinosinusitis","volume":"65","author":"M Koennecke","year":"2017","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"01","key":"ref24","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.cardiores.2006.03.020","article-title":"Intramyocardial delivery of human CD133+ cells in a SCID mouse cryoinjury model: Bone marrow vs. cord blood-derived cells","volume":"71","author":"N Ma","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"04","key":"ref25","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2459\/JCM.0b013e328343d708","article-title":"Myocardial blood flow and infarct size after CD133+ cell injection in large myocardial infarction with good recanalization and poor reperfusion: results from a randomized controlled trial","volume":"12","author":"A Colombo","year":"2011","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"12","key":"ref26","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.dld.2015.08.018","article-title":"Reinfusion of highly purified CD133+ bone marrow-derived stem\/progenitor cells in patients with end-stage liver disease: A phase I clinical trial","volume":"47","author":"P Andreone","year":"2015","journal-title":"Dig Liver Dis"},{"issue":"03","key":"ref27","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1002\/hep.24739","article-title":"CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin\/interleukin-8\/CXCL1 signaling","volume":"55","author":"K H Tang","year":"2012","journal-title":"Hepatology"},{"issue":"20","key":"ref28","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","author":"W M Association","year":"2013","journal-title":"JAMA"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"M M Bradford","year":"1976","journal-title":"Anal Biochem"},{"issue":"12","key":"ref30","doi-asserted-by":"publisher","first-page":"21642","DOI":"10.1002\/jcp.28824","article-title":"New emerging roles of CD133 in cancer stem cell: Signaling pathway and miRNA regulation","volume":"234","author":"M Aghajani","year":"2019","journal-title":"J Cell Physiol"},{"issue":"05","key":"ref31","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1053\/j.gastro.2010.01.001","article-title":"Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis","volume":"138","author":"S BH Ko","year":"2010","journal-title":"Gastroenterology"},{"issue":"14","key":"ref32","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.1158\/0008-5472.can-18-2659","article-title":"MicroRNA-92 Expression in CD133+ Melanoma Stem Cells Regulates Immunosuppression in the Tumor Microenvironment via Integrin-Dependent Activation of TGF\u03b2","volume":"79","author":"C Shidal","year":"2019","journal-title":"Cancer Res"},{"issue":"04","key":"ref33","doi-asserted-by":"publisher","first-page":"e12957","DOI":"10.1111\/acel.12957","article-title":"Transcription factor networks in aged na\u00efve CD4 T cells bias lineage differentiation","volume":"18","author":"B Hu","year":"2019","journal-title":"Aging Cell"},{"issue":"01","key":"ref34","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1038\/s41467-019-09401-9","article-title":"IL-4 together with IL-1\u03b2 induces antitumor Th9 cell differentiation in the absence of TGF-\u03b2 signaling","volume":"10","author":"G Xue","year":"2019","journal-title":"Nat Commun"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.dci.2019.02.019","article-title":"Regulation of FOXP3 expression in myeloid cells in response to all-trans-retinoic acid, interleukin 2 and transforming growth factor \u03b2","volume":"96","author":"A Ilnicka","year":"2019","journal-title":"Dev Comp Immunol"},{"issue":"01","key":"ref36","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/imm.12938","article-title":"The role of transforming growth factor \u03b2 in T helper 17 differentiation","volume":"155","author":"S Zhang","year":"2018","journal-title":"Immunology"},{"issue":"05","key":"ref37","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1177\/1945892418787132","article-title":"Biologics in Chronic Rhinosinusitis: An Update and Thoughts for Future Directions","volume":"32","author":"K A Smith","year":"2018","journal-title":"Am J Rhinol Allergy"},{"issue":"04","key":"ref38","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S1359-6101(01)00016-8","article-title":"Interleukin-8 and human cancer biology","volume":"12","author":"K Xie","year":"2001","journal-title":"Cytokine Growth Factor Rev"},{"issue":"03","key":"ref39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000363061","article-title":"Neuro-immuno-endocrine modulation in marathon runners","volume":"22","author":"A LL Bachi","year":"2015","journal-title":"Neuroimmunomodulation"},{"issue":"06","key":"ref40","doi-asserted-by":"publisher","first-page":"e0157058","DOI":"10.1371\/journal.pone.0157058","article-title":"Diesel Exhaust Particles Upregulate Interleukins IL-6 and IL-8 in Nasal Fibroblasts","volume":"11","author":"J A Kim","year":"2016","journal-title":"PLoS One"},{"issue":"03","key":"ref41","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/1061186X.2018.1479756","article-title":"CD133: beyond a cancer stem cell biomarker","volume":"27","author":"A Barzegar Behrooz","year":"2019","journal-title":"J Drug Target"}],"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1726043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T02:05:45Z","timestamp":1643162745000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1726043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":41,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,1,25]]},"published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1726043","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"type":"print","value":"1809-9777"},{"type":"electronic","value":"1809-4864"}],"subject":[],"published":{"date-parts":[[2021,6,25]]}}}