{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:30:02Z","timestamp":1771655402735,"version":"3.50.1"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Intraneural perineurioma is a rare tumor entity. It is a benign, very slow growing peripheral nerve sheath tumor that typically occurs in children and young adults. Motor deficits and muscle atrophy are classic presenting symptoms, while sensory deficits are rare at the onset of the disease. Recommended treatment strategies are lacking. We have evaluated the clinical follow-up and our experience with treatment of this rare entity.<\/jats:p><jats:p>\n          Methods\u2003A total of 30 patients with intraneural perineuriomas were assessed retrospectively. Demographic data, clinical symptoms, diagnostic examinations, therapy strategies, and clinical outcome were analyzed. Descriptive statistical methods were used for evaluation.<\/jats:p><jats:p>\n          Results\u2003The mean age was 22 years. Eleven women and 19 men were affected. The lesion occurred in the area of the upper extremity in 16 patients and in the area of the lower extremity in 14 patients. The most frequently affected nerve was the sciatic nerve, followed by the radial nerve. All patients showed a motor deficit to some extent. Seventy percent (n\u2009=\u200921) revealed atrophy, 43.3% (n\u2009=\u200913) had sensitive deficits, and 17% (n\u2009=\u20095) suffered of pain. Fascicle biopsies were performed in 26 patients (87%). In four patients (13%), the tumor was completely resected and then reconstructed via nerve grafts. Seventy percent of the patients (n\u2009=\u200921) received a magnetic resonance imaging (MRI) within 5 years postoperatively, in which no progress was shown.<\/jats:p><jats:p>\n          Conclusions\u2003To diagnose perineurioma, it is essential to take a biopsy of an enlarged, nonfunctional fascicle. Furthermore, a long-distance epineuriotomy to decompress the hypertrophic fascicle is reasonable. To preserve the nerves' residual function, a complete resection is not recommended. Results after grafting are poor. One reason for this might be residual tumor cells along the nerve that cannot be visualized. Malignant transformation is not yet reported and tumor growth is stable for years.<\/jats:p>","DOI":"10.1055\/s-0041-1726110","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T22:47:21Z","timestamp":1621896441000},"page":"001-005","source":"Crossref","is-referenced-by-count":17,"title":["Perineurioma: A Rare Entity of Peripheral Nerve Sheath Tumors"],"prefix":"10.1055","volume":"83","author":[{"given":"Christine","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, M\u00fcnchen Klinik Bogenhausen, Muenchen, Bayern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Pedro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Ulm, Guenzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrej","family":"Pala","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Ulm, Guenzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Heinen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oldenburg\/ Evangelisches Krankenhaus, Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Scheuerle","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University of Ulm, Guenzburg, Bayern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Ulm, Guenzburg, Bayern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Antoniadis","sequence":"additional","affiliation":[{"name":"Neurosurgery, Peripheral Nerve Surgery Unit, University of Ulm, G\u00fcnzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.5858\/2007-131-625-PADAUP","article-title":"Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm","volume":"131","author":"R S Macarenco","year":"2007","journal-title":"Arch Pathol Lab Med"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3171\/jns.2001.94.5.0811","article-title":"Intraneural perineurioma of the common peroneal nerve. Case report and review of the literature","volume":"94","author":"M E Heilbrun","year":"2001","journal-title":"J Neurosurg"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.5858\/2007-131-1382-IPASRW","article-title":"Intraneural perineurioma: a systematic review with illustrative cases","volume":"131","author":"B L Boyanton Jr","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/brain\/awp169","article-title":"Longitudinal study of intraneural perineurioma: a benign, focal hypertrophic neuropathy of youth","volume":"132","author":"M L Mauermann","year":"2009","journal-title":"Brain"},{"issue":"08","key":"ref5","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00381-016-3089-z","article-title":"Diagnosis and outcome of childhood perineurioma","volume":"32","author":"H J McMillan","year":"2016","journal-title":"Childs Nerv Syst"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.3171\/2015.6.FOCUS15225","article-title":"The almost-invisible perineurioma","volume":"39","author":"C E Restrepo","year":"2015","journal-title":"Neurosurg Focus"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/jns.12240","article-title":"Intraneural perineuriomas: diagnostic value of magnetic resonance neurography","volume":"23","author":"L Le\u00f3n Cejas","year":"2018","journal-title":"J Peripher Nerv Syst"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1055\/s-2008-1077081","article-title":"Intraneural perineuriomas; a rare entity. Clinical, surgical and neuropathological details in the management of these lesions","volume":"69","author":"C Scheller","year":"2008","journal-title":"Zentralbl Neurochir"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3171\/2017.5.JNS17905","article-title":"Clinicoradiological features of intraneural perineuriomas obviate the need for tissue diagnosis","volume":"129","author":"T J Wilson","year":"2018","journal-title":"J Neurosurg"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/00006123-199807000-00051","article-title":"Resection and graft repair for localized hypertrophic neuropathy","volume":"43","author":"J P Gruen","year":"1998","journal-title":"Neurosurgery"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1726110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:53:59Z","timestamp":1643763239000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1726110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,24]]},"references-count":10,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,2,1]]},"published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1726110","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,24]]}}}