{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:35Z","timestamp":1740126815327,"version":"3.37.3"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>\n            Objective\u2003The study aimed to compare the efficacy and safety of two different nasal high-flow rates for primary respiratory support in preterm neonates<\/jats:p><jats:p>\n            Study Design\u2003In this single-center, double-blinded randomized controlled trial, preterm neonates \u226528 weeks of gestation with respiratory distress from birth were randomized to treatment with either increased nasal flow therapy (8\u201310 L\/min) or standard nasal flow therapy (5\u20137 L\/min). The primary outcome of nasal high-flow therapy failure was a composite outcome defined as the need for higher respiratory support (continuous positive airway pressure [CPAP] or mechanical ventilation) or surfactant therapy.<\/jats:p><jats:p>\n            Results\u2003A total of 212 neonates were enrolled. Nasal high-flow failure rate in the increased flow group was similar to the standard flow group (22 vs. 29%, relative risk\u2009=\u20090.81 [95% confidence interval: 0.57\u20131.15]). However, nasal flow rate escalation was significantly more common in the standard flow group (64 vs. 43%, p\u2009=\u20090.004). None of the infants in the increased flow group developed air leak syndromes.<\/jats:p><jats:p>\n            Conclusion\u2003Higher nasal flow rate (8\u201310 L\/min) when compared with lower nasal flow rate of 5 to 7 L\/min did not reduce the need for higher respiratory support (CPAP\/mechanical ventilation) or surfactant therapy in moderately and late preterm neonates. However, initial flow rates of 5 L\/min were not optimal for most preterm infants receiving primary nasal flow therapy.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1726122","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T23:48:10Z","timestamp":1616543290000},"page":"1693-1701","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Two Different Flow Rates of Nasal High-Flow Therapy in Preterm Neonates \u226528 Weeks of Gestation: A Randomized Controlled Trial"],"prefix":"10.1055","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1305-1005","authenticated-orcid":false,"given":"Haribalakrishna","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Surya Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Sakharkar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Surya Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Majarikar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Surya Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Division of Neonatology, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandkishor S.","family":"Kabra","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Surya Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhawandeep","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Surya Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Surya Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"F371","DOI":"10.1136\/archdischild-2016-310497","article-title":"Changes in the use of humidified high flow nasal cannula oxygen","volume":"101","author":"S Shetty","year":"2016","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/apa.13644","article-title":"Survey of noninvasive 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