{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:11Z","timestamp":1740126851123,"version":"3.37.3"},"reference-count":94,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The global prevalence of dementia is expected to triple by the year 2050. This impending health care crisis has led to new heights of public awareness and general concern regarding cognitive impairment. Subsequently, clinicians are seeing more and more people presenting with cognitive concerns. It is important that clinicians meet these concerns with a strategy promoting accurate diagnoses. We have diagramed and described a practical approach to cognitive impairment. Through an algorithmic approach, we determine the presence and severity of cognitive impairment, systematically evaluate domains of function, and use this information to determine the next steps in evaluation. We also discuss how to proceed when cognitive impairment is associated with motor abnormalities or rapid progression.<\/jats:p>","DOI":"10.1055\/s-0041-1726354","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T23:47:54Z","timestamp":1637970474000},"page":"686-698","source":"Crossref","is-referenced-by-count":0,"title":["A Neurologist's Practical Approach to Cognitive Impairment"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-2248","authenticated-orcid":false,"given":"Philip W.","family":"Tipton","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-5538","authenticated-orcid":false,"given":"Gregory S.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neill","family":"Graff-Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"G M McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jalz.2019.01.010","article-title":"2019 Alzheimer's disease facts and figures","volume":"15","author":"Alzheimer's Association","year":"2019","journal-title":"Alzheimers Dement"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/NEN.0b013e31824b211b","article-title":"Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010","volume":"71","author":"T G Beach","year":"2012","journal-title":"J Neuropathol Exp Neurol"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jalz.2017.09.014","article-title":"The limbic and neocortical contribution of \u03b1-synuclein, tau, and amyloid \u03b2 to disease duration in dementia with Lewy bodies","volume":"14","author":"T J Ferman","year":"2018","journal-title":"Alzheimers Dement"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1474-4422(16)30291-5","article-title":"Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis","volume":"16","author":"D J Irwin","year":"2017","journal-title":"Lancet Neurol"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00401-015-1406-3","article-title":"Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes","volume":"129","author":"L Walker","year":"2015","journal-title":"Acta Neuropathol"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00401-002-0634-5","article-title":"Incidence of cerebrovascular lesions in Alzheimer's disease: a postmortem study","volume":"105","author":"K A Jellinger","year":"2003","journal-title":"Acta Neuropathol"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1590\/1980-57642016dn11-040005","article-title":"Mixed dementia: a review of the evidence","volume":"11","author":"N Custodio","year":"2017","journal-title":"Dement Neuropsychol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neurobiolaging.2017.08.029","article-title":"Age and the association of dementia-related pathology with trajectories of cognitive decline","volume":"61","author":"W J Jansen","year":"2018","journal-title":"Neurobiol Aging"},{"issue":"03","key":"ref11","first-page":"189","article-title":"\u201cMini-mental state\u201d. 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