{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:59:19Z","timestamp":1787313559464,"version":"build-2736575974"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003The etiology of autism spectrum disorder (ASD) is complex and involves the interplay of genetic and environmental factors.<\/jats:p>\n                  <jats:p>Aim\u2003We sought to identify potential prenatal, perinatal, and neonatal risk factors for ASD in a unique population of children who had perinatal complications and required care in a neonatal intensive care unit (NICU).<\/jats:p>\n                  <jats:p>Methods\u2003This prospective cohort study included 73 patients discharged from a NICU who received long-term follow-up at the largest children's hospital in Brazil. Potential risk factors were compared between 44 children with a diagnosis of ASD and 29 children without using the Mann\u2013Whitney U test. Proportions were analyzed using the chi-square test. Simple and multiple logistic regression tests were performed.<\/jats:p>\n                  <jats:p>Results\u2003Of 38 factors analyzed, the following 7 were associated with ASD: family history of neuropsychiatric disorders (p\u2009=\u20090.049); maternal psychological distress during pregnancy (p\u2009=\u20090.007);\u2009\u2265\u200926 days in the NICU (p\u2009=\u20090.001); feeding tube for\u2009\u2265\u200915 days (p\u2009=\u20090.014); retinopathy of prematurity (p\u2009=\u20090.022); use of three or more antibiotics (p\u2009=\u20090.008); and co-sleeping until up to 2 years of age (p\u2009=\u20090.004).<\/jats:p>\n                  <jats:p>Conclusion\u2003This study found associations between specific risk factors during critical neurodevelopmental periods and a subsequent diagnosis of ASD. Knowledge of the etiologic factors that may influence the development for ASD is paramount for the development of intervention strategies and improvement of prognoses.<\/jats:p>","DOI":"10.1055\/s-0041-1726401","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T19:13:17Z","timestamp":1618427597000},"page":"284-293","source":"Crossref","is-referenced-by-count":2,"title":["Potential Risk Factors for Autism in Children Requiring Neonatal Intensive Care Unit"],"prefix":"10.1055","volume":"52","author":[{"given":"Mar\u00edlia Barbosa de","family":"Matos","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics, Children's Hospital Pequeno Pr\u00edncipe, Waldemar Monastier Hospital, Curitiba, Brazil"},{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Curitiba, Brazil"},{"name":"Faculdades Pequeno Pr\u00edncipe, Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago S.","family":"Bara","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Curitiba, Brazil"},{"name":"Faculdades Pequeno Pr\u00edncipe, Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rico P. 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