{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:37:17Z","timestamp":1758926237588,"version":"3.37.3"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>\n            Objective\u2003A majority of studies evaluating the risk of vertical transmission and adverse outcomes in pregnancies with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mostly based on third-trimester infections. There is limited data available on pregnancy sequelae of maternal infection in the first or second trimester.<\/jats:p><jats:p>\n            Study Design\u2003We present a patient with monochorionic\u2013diamniotic twins that develops coronavirus disease 2019 infection at 15 weeks of gestation. The pregnancy is further complicated by stage II twin\u2013twin transfusion syndrome. She undergoes laser ablation, which is complicated by development of a subchorionic hematoma. The patient then develops Escherichia coli bacteremia, resulting in septic shock and preterm labor followed by previable delivery at 21 weeks of gestation. Amniotic fluid and placenta were negative for SARS-CoV-2 by real-time polymerase chain reaction.<\/jats:p><jats:p>\n            Conclusion\u2003This case of SARS-CoV-2 argues against transplacental transmission after a second-trimester infection but brings attention to the possible downstream complications that may arise following early infection.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1726428","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T23:15:14Z","timestamp":1618442114000},"page":"747-752","source":"Crossref","is-referenced-by-count":4,"title":["Complicated Monochorionic\u2013Diamniotic Twins in a Pregnant Woman with COVID-19 in the Second Trimester"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2005-5562","authenticated-orcid":false,"given":"Thalia","family":"Mok","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deisy","family":"Contreras","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramen H.","family":"Chmait","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine\u2013University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilina D.","family":"Pluym","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalil","family":"Tabsh","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-9637","authenticated-orcid":false,"given":"Grace","family":"Aldrovandi","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-7022","authenticated-orcid":false,"given":"Yalda","family":"Afshar","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An interactive web-based dashboard to track COVID-19 in real time","volume":"20","author":"E Dong","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1473-3099(20)30176-6","article-title":"Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, 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