{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:49:39Z","timestamp":1765176579045,"version":"3.37.3"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study is to report our preliminary experience with the vastus lateralis myofascial free flap (VLMFF) for tongue reconstruction according to tongue and donor site functional outcomes. Twelve consecutive patients (F: 5; median age: 54.0 years, interquartile range or IQR 42.75\u201369.0) were included. The validated European Organization for Research and Treatment of Cancer of the Head and Neck 35 Quality of Life Questionnaire (EORTC QLQ-H&amp;N35) and the performance status scale for head and neck cancer (PSS-HN) questionnaires were used to assess the health-related quality of life (HRQOL). The lower extremity functional scale (LEFS) was used to self-report the donor area function. All patients were successfully treated, and no VLMFF failure was detected during a median follow-up period of 10.5 months (IQR: 6.5\u201333.0). The HRQOL showed a median EORTC QLQ-H&amp;N35 score of 56.0 (IQR: 50.0\u201372.5). The median PSS-HN score was 80.0 (IQR: 45.0\u201395.0), 75.0 (IQR: 62.5\u2013100.0), 75.0 (IQR: 62.5\u2013100.0) for \u201cNormalcy of Diet,\u201d \u201cPublic Eating,\u201d and \u201cUnderstandability of Speech,\u201d respectively. The self-reported function of the lower extremities (donor area) showed a median LEFS of 59.0 (IQR: 32.5\u201374.0). This study reports optimistic data regarding the functional and quality of life outcomes after tongue reconstruction using VLMFF. Prospective controlled studies are needed to demonstrate advantages and disadvantages when compared with other reconstructive techniques.<\/jats:p>","DOI":"10.1055\/s-0041-1726445","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:22:49Z","timestamp":1619482969000},"page":"681-687","source":"Crossref","is-referenced-by-count":4,"title":["Preliminary Functional Outcomes and Quality of Life after Tongue Reconstruction with the Vastus Lateralis Myofascial Free Flap"],"prefix":"10.1055","volume":"37","author":[{"given":"Armando","family":"De Virgilio","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, IRCCS Humanitas Clinical and Research Center, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-7785","authenticated-orcid":false,"given":"Andrea","family":"Costantino","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, IRCCS Humanitas Clinical and Research Center, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Pellini","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Regina Elena National Cancer Institute, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Petruzzi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Regina Elena National Cancer Institute, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Mercante","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, IRCCS Humanitas Clinical and Research Center, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Zocchi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Regina Elena National Cancer Institute, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4391-4932","authenticated-orcid":false,"given":"Tiziana","family":"Mondello","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, 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Engel","year":"2010","journal-title":"Plast Reconstr Surg"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/archotol.1994.01880300007002","article-title":"A systematic approach to functional reconstruction of the oral cavity following partial and total glossectomy","volume":"120","author":"M L Urken","year":"1994","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/hed.23862","article-title":"Quality of life in patients after resection of pT3 lateral tongue carcinoma: microvascular reconstruction versus primary closure","volume":"38","author":"M Canis","year":"2016","journal-title":"Head Neck"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/micr.30495","article-title":"Head and neck soft tissue reconstruction with anterolateral thigh flaps with various components: development of an algorithm for flap selection in different clinical scenarios","volume":"39","author":"A De Virgilio","year":"2019","journal-title":"Microsurgery"},{"issue":"09","key":"ref5","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.ijom.2020.01.022","article-title":"Free flap microvascular anastomosis in head and neck reconstruction using a 4K three-dimensional exoscope system (VITOM 3D)","volume":"49","author":"A De Virgilio","year":"2020","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"04","key":"ref6","first-page":"321","article-title":"Vastus lateralis myofascial free flap in tongue reconstruction","volume":"36","author":"R Pellini","year":"2016","journal-title":"Acta Otorhinolaryngology Ital"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.ijom.2016.03.009","article-title":"Reconstruction of the tongue and mouth floor with the myofascial vastus lateralis free flap after cancer ablation","volume":"45","author":"L Wang","year":"2016","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/hed.25466","article-title":"Classification of GLOSSECTOMIES: proposal for tongue cancer resections","volume":"41","author":"M Ansarin","year":"2019","journal-title":"Head Neck"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1200\/JCO.1999.17.3.1008","article-title":"Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35","volume":"17","author":"K Bjordal","year":"1999","journal-title":"J Clin Oncol"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2294::AID-CNCR17>3.0.CO;2-S","article-title":"The Performance Status Scale for Head and Neck Cancer Patients and the Functional Assessment of Cancer Therapy-Head and 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lateralis","volume":"14","author":"P C Revenaugh","year":"2012","journal-title":"Arch Facial Plast Surg"},{"issue":"05","key":"ref33","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/ca.20444","article-title":"Innervation of vastus lateralis muscle","volume":"20","author":"S Patil","year":"2007","journal-title":"Clin Anat"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10072-018-3687-5","article-title":"Vastus lateralis myofascial free flap for tongue reconstruction and hypoglossal-femoral anastomosis: neurophysiological study","volume":"40","author":"E Gali\u00e8","year":"2019","journal-title":"Neurol Sci"},{"issue":"02","key":"ref35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1055\/s-0036-1593772","article-title":"Optimizing outcomes following total and subtotal tongue reconstruction: a systematic review of the contemporary literature","volume":"33","author":"O J Manrique","year":"2017","journal-title":"J 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