{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:46:51Z","timestamp":1785577611800,"version":"3.56.0"},"reference-count":11,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nIntroduction\u2003Anion gap (AG) metabolic acidosis is common in critically ill patients. The relationship between initial AG at the time of admission to the medical intensive care unit (MICU) and mortality or length of stay is unclear. This study was undertaken to evaluate this relationship.<\/jats:p><jats:p>\nMaterials and Method\u2003We prospectively examined the acid\u2013base status of 500 consecutive patients at the time of MICU admission and outcome was measured in terms of mortality, length of ICU stay, need of ventilator, and laboratory parameters. The patients were divided into four stages based on the severity of AG. Outcome based on the severity of AG was measured, and comparisons that adjusted for baseline characteristics were performed.<\/jats:p><jats:p>\nResults\u2003This study showed that increased AG was associated with the higher mortality. Patients with the highest AG also had the longest length of stay in the MICU, and patients with normal acid\u2013base status had the shortest ICU length of stays (p &lt; 0.05).<\/jats:p><jats:p>\nConclusion\u2003A high AG at the time of admission to the MICU was associated with higher mortality and length of stays. Initial risk stratification based on AG and metabolic acidosis may help guide appropriate patient disposition (especially in patients without other definitive criteria for MICU admission) and assist with prognosis.<\/jats:p>","DOI":"10.1055\/s-0041-1726568","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T22:43:23Z","timestamp":1624661003000},"page":"107-111","source":"Crossref","is-referenced-by-count":14,"title":["Admission Anion Gap Metabolic Acidosis and Its Impact on Patients in Medical Intensive Care Unit"],"prefix":"10.25259","volume":"13","author":[{"given":"Akshay","family":"Dafal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourya","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apoorva","family":"Nirmal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"issue":"15","key":"ref1","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJMra1003327","article-title":"Physiological approach to assessment of acid-base disturbances","volume":"371","author":"K Berend","year":"2014","journal-title":"N Engl J Med"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1513\/AnnalsATS.201409-426OI","article-title":"Practical approach to physical-chemical acid-base management. 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A prospective, multiple-center study","volume":"15","author":"B Jung","year":"2011","journal-title":"Crit Care"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40560-016-0171-2","article-title":"Unmeasured anions and mortality in critically ill patients in 2016","volume":"4","author":"Y Kotake","year":"2016","journal-title":"J Intensive Care"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1726568.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:18:45Z","timestamp":1703405925000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/admission-anion-gap-metabolic-acidosis-and-its-impact-on-patients-in-medical-intensive-care-unit\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":11,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2021,9,1]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1726568","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}