{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:19:14Z","timestamp":1760015954109},"reference-count":11,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Neuromyelitis optica spectrum disorders (NMOSDs) usually manifest with features of long-segment myelitis and\/or optic neuritis. Area postrema involvement presents with nausea, vomiting, and intractable hiccups. Cerebral cortical involvement is a relatively uncommon phenomenon. This report describes an interesting case of aquaporin 4 antibody positive NMOSD with extensive cerebral cortical involvement in addition to area postrema and cervicomedullary lesions observed on magnetic resonance imaging. Following immunosuppressive therapy, good clinical response and near-complete resolution of brain imaging abnormalities were observed.<\/jats:p>","DOI":"10.1055\/s-0041-1726621","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T09:33:44Z","timestamp":1617701624000},"page":"431-434","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Extensive Cerebral Cortical Involvement in Aquaporin 4 Antibody Positive Neuromyelitis Optica Spectrum Disorder"],"prefix":"10.25259","volume":"12","author":[{"given":"Kiran Kumar","family":"Ramineni","sequence":"first","affiliation":[{"name":"Department of Neurology, Yashoda Superspeciality Hospital, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi Kanth","family":"Jakkani","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yashoda Superspeciality Hospital, Malakpet, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaik","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yashoda Superspeciality Hospital, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramakrishna","family":"Malla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yashoda Superspeciality Hospital, Malakpet, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"issue":"9","key":"10.1055\/s-0041-1726621\/ref-1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"Wingerchuk","year":"2007","journal-title":"Lancet Neurol"},{"issue":"17","key":"10.1055\/s-0041-1726621\/ref-2","doi-asserted-by":"crossref","first-page":"e1642","DOI":"10.1212\/WNL.0000000000006392","article-title":"Area postrema syndrome: frequency, criteria, and severity in AQP4-IgG-positive NMOSD","volume":"91","author":"Shosha","year":"2018","journal-title":"Neurology"},{"issue":"2","key":"10.1055\/s-0041-1726621\/ref-3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International Panel for NMO Diagnosis. 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