{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:24:06Z","timestamp":1785324246140,"version":"3.55.0"},"reference-count":17,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>\n<jats:bold>Objectives<\/jats:bold>\u2003We aimed to develop a prognostic model for the prediction of in-hospital mortality in patients with traumatic brain injury (TBI) admitted to the neurosurgery intensive care unit (ICU) of our institute.<\/jats:p>\n<jats:p>\n<jats:bold>Materials and Methods<\/jats:bold>\u2003The clinical and computed tomography scan data of consecutive patients admitted after a diagnosis TBI in ICU were reviewed. Construction of the model was done by using all the variables of Corticosteroid Randomization after Significant Head Injury and International Mission on Prognosis and Analysis of Clinical Trials in TBI models. The endpoint was in-hospital mortality.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003A total of 243 patients with TBI were admitted to ICU during the study period. The in-hospital mortality was 15.3%. On multivariate analysis, the Glasgow coma scale (GCS) at admission, hypoxia, hypotension, and obliteration of the third ventricle\/basal cisterns were significantly associated with mortality. Patients with hypoxia had eight times, with hypotensions 22 times, and with obliteration of the third ventricle\/basal cisterns three times more chance of death. The TBI score was developed as a sum of individual points assigned as follows: GCS score 3 to 4 (+2 points), 5 to 12 (+1), hypoxia (+1), hypotension (+1), and obliteration third ventricle\/basal cistern (+1). The mortality was 0% for a score of \u201c0\u201d and 85% for a score of \u201c4.\u201d<\/jats:p>\n<jats:p>\n<jats:bold>Conclusion<\/jats:bold>\u2003The outcome of patients treated in ICU was based on common admission variables. A simple clinical grading score allows risk stratification of patients with TBI admitted in ICU.<\/jats:p>","DOI":"10.1055\/s-0041-1726623","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T09:33:44Z","timestamp":1617701624000},"page":"368-375","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development of a Prognostic Model to Predict Mortality after Traumatic Brain Injury in Intensive Care Setting in a Developing Country"],"prefix":"10.25259","volume":"12","author":[{"given":"Mini","family":"Jayan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India"},{"name":"NIHR Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagavatula Indira","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India"},{"name":"NIHR Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjaya I.","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, RV Aster Hospital, Bengaluru, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhas K.","family":"Konar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"issue":"4","key":"10.1055\/s-0041-1726623\/ref-1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jclinepi.2007.06.011","article-title":"A systematic review finds methodological improvements necessary for prognostic models in determining traumatic brain injury outcomes","volume":"61","author":"Mushkudiani","year":"2008","journal-title":"J Clin Epidemiol"},{"key":"10.1055\/s-0041-1726623\/ref-2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-3-211-78205-7_20","article-title":"New approaches to increase statistical power in TBI trials: insights from the IMPACT study","volume":"101","author":"Maas","year":"2008","journal-title":"Acta Neurochir Suppl (Wien)"},{"issue":"10","key":"10.1055\/s-0041-1726623\/ref-3","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1097\/CCM.0b013e3181ab85ec","article-title":"Baseline characteristics and statistical power in randomized controlled trials: selection, prognostic targeting, or covariate adjustment?","volume":"37","author":"Roozenbeek","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1055\/s-0041-1726623\/ref-4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1472-6947-6-38","article-title":"Systematic review of prognostic models in traumatic brain injury","volume":"6","author":"Perel","year":"2006","journal-title":"BMC Med Inform Decis Mak"},{"issue":"5","key":"10.1055\/s-0041-1726623\/ref-5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/MCC.0b013e3283307a26","article-title":"Prediction of outcome in severe traumatic brain injury","volume":"15","author":"Menon","year":"2009","journal-title":"Curr Opin Crit Care"},{"issue":"2","key":"10.1055\/s-0041-1726623\/ref-6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jclinepi.2005.06.009","article-title":"Some prognostic models for traumatic brain injury were not valid","volume":"59","author":"Hukkelhoven","year":"2006","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"10.1055\/s-0041-1726623\/ref-7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1089\/neu.2006.0024","article-title":"Prognosis and clinical trial design in traumatic brain injury: the IMPACT study","volume":"24","author":"Maas","year":"2007","journal-title":"J Neurotrauma"},{"issue":"94\/42","key":"10.1055\/s-0041-1726623\/ref-8","first-page":"1321","article-title":"CRASH trial collaborators. 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