{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:42:14Z","timestamp":1785328934995,"version":"3.55.0"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Air leak is the most common complication after lung resection and leads to increased length of hospital (LOH) stay or patient discharge with a chest tube. Management by autologous blood patch pleurodesis (ABPP) is controversial because few studies exist, and the technique has yet to be standardized.<\/jats:p><jats:p>\n          Methods\u2003We retrospectively reviewed patients undergoing ABPP for prolonged air leak (PAL) following lobectomy in three centers, between January 2014 and December 2019. They were divided into two groups: Group A, 120\u2009mL of blood infused; Group B, 60\u2009mL. Propensity score-matched (PSM) analysis was performed, and 23 patients were included in each group. Numbers and success rates of blood patch, time to cessation of air leak, time to chest tube removal, reoperation, LOH, and complications were examined. Univariate and multivariate analysis of variables associated with an increased risk of air leak was performed.<\/jats:p><jats:p>\n          Results\u2003After the PSM, 120\u2009mL of blood is statistically significant in reducing the number of days before chest tube removal after ABPP (2.78 vs. 4.35), LOH after ABPP (3.78 vs. 10.00), and LOH (8.78 vs. 15.17). Complications (0 vs. 4) and hours until air leak cessation (6.83 vs. 3.91, range 1\u201313) after ABPP were also statistically different (p\u2009&lt;\u20090.05). Air leaks that persisted for up to 13\u2009hours required another ABPP. No patient had re-operation or long-term complications related to pleurodesis.<\/jats:p><jats:p>\n          Conclusion\u2003In our experience, 120\u2009mL is the optimal amount of blood and the procedure can be repeated every 24\u2009hours with the chest tube clamped.<\/jats:p>","DOI":"10.1055\/s-0041-1727129","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T01:07:04Z","timestamp":1618362424000},"page":"671-676","source":"Crossref","is-referenced-by-count":6,"title":["Autologous Blood Pleurodesis: What Is the Optimal Time Interval and Amount of Blood?"],"prefix":"10.1055","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-9601","authenticated-orcid":false,"given":"Alessio","family":"Campisi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Department of Thoracic Diseases, Thoracic Surgery Unit, University of Bologna, G.B. Morgagni-L. Pierantoni Hospital, Forl\u00ec, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dell'Amore","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery and Vascular Sciences, Division of Thoracic Surgery, Padua University Hospital, University of Padua, Via Giustiniani 1, Padua (PD), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo Paolo","family":"Ciarrocchi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Diseases, Thoracic Surgery Unit, University of Bologna, G.B. Morgagni-L. Pierantoni Hospital, Forl\u00ec, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Faccioli","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery and Vascular Sciences, Division of Thoracic Surgery, Padua University Hospital, University of Padua, Via Giustiniani 1, Padua (PD), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bertolaccini","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, European Institute of Oncology IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Rea","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery and Vascular Sciences, Division of Thoracic Surgery, Padua University Hospital, University of Padua, Via Giustiniani 1, Padua (PD), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Stella","sequence":"additional","affiliation":[{"name":"Department of Thoracic Diseases, Thoracic Surgery Unit, University of Bologna, G.B. Morgagni-L. Pierantoni Hospital, Forl\u00ec, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.athoracsur.2010.02.054","article-title":"A scoring system to predict the risk of prolonged air leak after lobectomy","volume":"90","author":"A Brunelli","year":"2010","journal-title":"Ann Thorac Surg"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/MCP.0b013e32835358ca","article-title":"Blood patch for persistent air leak: a review of the current literature","volume":"18","author":"K Manley","year":"2012","journal-title":"Curr Opin Pulm Med"},{"issue":"S 32","key":"ref3","doi-asserted-by":"crossref","first-page":"S3789","DOI":"10.21037\/jtd.2018.10.05","article-title":"Optimal management of postoperative parenchymal air leaks","volume":"10","author":"D G French","year":"2018","journal-title":"J Thorac Dis"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chest.2017.02.020","article-title":"Management of persistent air leaks","volume":"152","author":"K C Dugan","year":"2017","journal-title":"Chest"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jtcvs.2006.05.033","article-title":"Autologous blood patch in persistent air leaks after pulmonary resection","volume":"132","author":"A Droghetti","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000226277","article-title":"Persistent pleuropulmonary air leak treated with autologous blood: results from a university hospital and review of literature","volume":"79","author":"F H Oliveira","year":"2010","journal-title":"Respiration"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"D Dindo","year":"2004","journal-title":"Ann Surg"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0039-6109(02)00026-9","article-title":"Advances in thoracostomy tube management","volume":"82","author":"R J Cerfolio","year":"2002","journal-title":"Surg Clin North Am"},{"issue":"06","key":"ref9","first-page":"428","article-title":"Autologous blood for pleurodesis in recurrent and chronic spontaneous pneumothorax","volume":"30","author":"C L Robinson","year":"1987","journal-title":"Can J 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pleurodesis effective for determining the cessation of persistent air leak?","volume":"11","author":"A Chambers","year":"2010","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/MCP.0b013e3282fcea76","article-title":"The utility of intrapleural instillation of autologous blood for prolonged air leak after lobectomy","volume":"14","author":"A Ahmed","year":"2008","journal-title":"Curr Opin Pulm Med"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jtcvs.2006.10.042","article-title":"Pleurodesis with an autologous blood patch to prevent persistent air leaks after lobectomy","volume":"133","author":"C Andreetti","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"03","key":"ref16","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.athoracsur.2006.04.015","article-title":"Intrapleural instillation of autologous blood in the treatment of prolonged air leak after lobectomy: a prospective randomized controlled trial","volume":"82","author":"M J Shackcloth","year":"2006","journal-title":"Ann Thorac Surg"},{"issue":"05","key":"ref17","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.ejcts.2004.07.034","article-title":"A prospective study of autologous \u2018blood patch\u2019 pleurodesis for persistent air leak after pulmonary resection","volume":"26","author":"L Lang-Lazdunski","year":"2004","journal-title":"Eur J Cardiothorac Surg"}],"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1727129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T01:53:53Z","timestamp":1671501233000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1727129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,13]]},"references-count":17,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2022,12,19]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1727129","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,13]]}}}