{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:07Z","timestamp":1740126847587,"version":"3.37.3"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003We evaluate the surgical outcome of clinically single-zone N2 lung cancer limited to aortopulmonary zone (AP zone; lymph node #5 or #6).<\/jats:p><jats:p>\n          Patients and Methods\u2003We performed a retrospective analysis of patients with non-small cell lung cancer, in whom mediastinal lymph node metastasis was confined to AP zone.<\/jats:p><jats:p>\n          Results\u2003A total of 84 patients who underwent upfront surgery were included in final analysis. Among these patients, pathological nodal outcomes were pN0\u20131 in 27 patients (32.1%), pN2a in 31 (36.9%), and pN2b in 26 (31.0%). In multivariate analysis, adenocarcinoma (p\u2009=\u20090.005) and staging workup without endobronchial ultrasound-transbronchial needle aspiration (p\u2009=\u20090.002) were independent risk factors for unexpected pN2b. The 5-year overall survival (OS) and disease-free survival (DFS) were 55.9 and 54.4%, respectively. There was no survival difference among patients with pN0\u20131, pN2a, and pN2b (p\u2009=\u20090.717). In survival analysis, there were no significant risk factors for OS. However, female sex and the ratio of positive lymph nodes to removed lymph nodes were significant risk factors for DFS in multivariate analysis (p\u2009=\u20090.032 and p\u2009=\u20090.009).<\/jats:p><jats:p>\n          Conclusion\u2003In this study, cN2a in the AP zone with current diagnostic tool exhibited a relatively high false-positive rate (cN2\/pN0\u20131; 32.1%). However, despite the possibility of pN2b, there were no significant differences in survival outcome according to the pathologic nodal stage.<\/jats:p>","DOI":"10.1055\/s-0041-1727206","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T22:52:37Z","timestamp":1619045557000},"page":"251-257","source":"Crossref","is-referenced-by-count":1,"title":["Surgical Outcomes of Non-Small Cell Lung Cancer in Single-Zone N2 in the Aortopulmonary Zone"],"prefix":"10.1055","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5811-5407","authenticated-orcid":false,"given":"Kanghoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, College of Medicine, Catholic Kwandong University, Incheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Sook","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeong Ryul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Il","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Seoul, 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