{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:07:03Z","timestamp":1773000423365,"version":"3.50.1"},"reference-count":27,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>\n<jats:bold>Background<\/jats:bold>\u2003Worldwide leprosy is a common cause of peripheral neuropathy. Electrophysiology is underutilized in its diagnosis.<\/jats:p>\n<jats:p>\n<jats:bold>Objective<\/jats:bold>\u2003This study aims to evaluate the usefulness of electrophysiological study in the diagnosis of leprous neuropathy.<\/jats:p>\n<jats:p>\n<jats:bold>Materials and Methods<\/jats:bold>\u2003Clinical and electrophysiological abnormalities of 36 histopathology proven leprosy patients from January 2015 to January 2017 were studied.<\/jats:p>\n<jats:p>\n<jats:bold>Statistical Analysis<\/jats:bold>\u2003Proportions were compared by Chi-square test.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003Total patients were 36. Thirty-four patients had abnormal electrophysiology and 34 had neurological deficits like weakness, sensory changes, and thickening. By clinical examination, multiple nerve involvement (motor weakness, sensory changes, and nerve thickening) occurred in 29, single nerve in 5, and no nerve involvement in 2. With electrophysiology, multiple nerve involvement (mononeuritis multiplex) was present in 32, single nerve in 2, and normal conduction parameters in 2. From the 36 patients, a total of 1,008 nerves were subjected to clinical examination and 132 were picked up clinically as affected, (13.1%). Electrophysiological study was done in 504 nerves, and 215 were found to be involved, (43%). Nerve abnormality detected by electrophysiology is significantly higher than clinical detection. (Chi-square =164.4054; <jats:italic>p<\/jats:italic> = 0.0000). Clinically, the most commonly affected nerve was unar (27) and the least affected was median (2) nerve. Electrophysiology detected 69% of nerves with demyelination and 35% of nerves with axonal features (mosaic pattern).<\/jats:p>\n<jats:p>\n<jats:bold>Discussion<\/jats:bold>\u2003There was subclinical neuropathy with electroclinical dissociation, as evidenced by more abnormality in electrophysiology than clinical examination. The nerve involvement was mononeuritis or mononeuritis multiplex pattern, both clinically and electrophysiologically. Electrophysiology showed both axonal and demyelinating nerve involvement (mosaic pattern). All the three features are present in leprous neuropathy. In corollary, if a patient has these electrophysiological features, he should be thoroughly investigated for leprosy.<\/jats:p>\n<jats:p>\n<jats:bold>Conclusion<\/jats:bold>\u2003Triple findings, such as subclinical neuropathy with electroclinical dissociation, mononeuritis multiplex, and mosaic pattern of demyelination and axonopathy, suggest leprous neuropathy<\/jats:p>","DOI":"10.1055\/s-0041-1727575","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T22:43:47Z","timestamp":1623883427000},"page":"530-534","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Leprous Neuropathy: Observational Study Highlighting the Role of Electrophysiology in Early Diagnosis"],"prefix":"10.25259","volume":"12","author":[{"given":"Beena V.","family":"Vijayan","sequence":"first","affiliation":[{"name":"Department of Neurology, Government Medical College Hospital, Affiliated to Kerala University of Health Sciences, Kottayam, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria R.","family":"Dominic","sequence":"additional","affiliation":[{"name":"Department of Neurology, Government Medical College Hospital, Affiliated to Kerala University of Health Sciences, Kottayam, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayan C.P.","family":"Nair","sequence":"additional","affiliation":[{"name":"Kerala University of Health Sciences, Thrissur, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"issue":"4","key":"10.1055\/s-0041-1727575\/ref-2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.47276\/lr.80.4.353","article-title":"Enhanced global strategy for further reducing the disease burden due to leprosy: 2011-2015","volume":"80","author":"Pannikar","year":"2009","journal-title":"Lepr 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