{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:21Z","timestamp":1781179101088,"version":"3.54.1"},"reference-count":10,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Background\u2003Adult Philadelphia-positive (Ph\u2009+\u2009) acute lymphoblastic leukemia (ALL) is a distinct entity with poor prognosis. Treatment with tyrosine kinase inhibitors improved responses but still with poor outcomes. We evaluated treatment outcomes in these patients treated in limited-resource settings in the absence of availability of allogeneic stem cell transplantation (ASCT).<\/jats:p>\n                  <jats:p>Materials and Methods\u2003We studied case record files of the adult patients diagnosed with Ph+ ALL.<\/jats:p>\n                  <jats:p>Results\u2003A total of 18 patients were evaluated retrospectively. The median age of presentation was 28 years. Male-to-female ratio was 1:1. Patients presented with fever and fatigue. Six patients (33.33%) presented with cervical lymphadenopathy. Clinical splenomegaly was present in 16 (88.88%) patients on palpation, whereas on ultrasonographic evaluation, all 18 patients had splenomegaly. The median size of the spleen was 15\u2009cm. Hepatomegaly was seen in 5 (27%) patients. All 18 patients had anemia at the time of presentation. Leukocytosis was seen in 17 (94.44%) patients, whereas 1 (5.56%) patient presented with low total leukocyte count. The median platelet count at the time of presentation was 30,000\/mm.3 On peripheral smear, median number of blast cells was 55%, and on bone marrow aspiration samples, median blast percentage seen was 70%. Conventional cytogenetics was done in all the patients on bone marrow aspiration samples. Ten patients (55.55%) had t(9;22) \u2013 Ph chromosome. One patient (5.56%) on cytogenetics showed double Ph chromosome. The median value of breakpoint cluster region-ABL1 transcript in IS% was 13%. Seventeen (94.44%) received ALL protocol (BFM95) along with tyrosine kinase inhibitor (imatinib). One (5.56%) patient refused aggressive cytotoxic chemotherapy. No patient underwent ASCT. The median duration of follow-up was 7.5 months, ranging from 3 to 16 months. Median overall survival (OS) was 7.5 months and 2-year OS was 33.33%.<\/jats:p>\n                  <jats:p>Conclusion\u2003Poor prognosis of this disease, especially in the absence of ASCT, remains a major challenge in the treatment.<\/jats:p>","DOI":"10.1055\/s-0041-1728224","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T18:47:45Z","timestamp":1681152465000},"page":"203-206","source":"Crossref","is-referenced-by-count":1,"title":["Adult Philadelphia-Positive Acute Lymphoblastic Leukemia: A Single-Institution Experience in Limited-Resource Setting"],"prefix":"10.25259","volume":"13","author":[{"given":"Rudresha Haleshappa","family":"Antapura","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amale Baburao","family":"Vaibhav","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokanatha","family":"Dasappa","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linu Abraham","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallekavu Channappa","family":"Sureshbabu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadabur Nagendrappa","family":"Lokesh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakkavalli Krishnappa","family":"Rajeev","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smitha C.","family":"Saldanha","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tirumala","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, 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