{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:15:27Z","timestamp":1759580127331,"version":"3.37.3"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 78-year-old Japanese male with Clostridium perfringens septicemia and cholecystitis was found to have thrombosis in the left branch of intrahepatic portal vein as well as superior mesenteric vein. Visceral vein thrombosis (VVT) in this case was associated with protein C deficiency, due to a heterozygous mutation, p. Arg185Met. Our experience emphasizes that VVT, or other thromboembolic events, may occur in later life, triggered by environmental thrombosis risk factors, together with underlying hereditary protein C gene mutation.<\/jats:p>","DOI":"10.1055\/s-0041-1728664","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:47:21Z","timestamp":1622076441000},"page":"e171-e173","source":"Crossref","is-referenced-by-count":2,"title":["Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis"],"prefix":"10.1055","volume":"05","author":[{"given":"Kiyoko","family":"Kanosue","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Nagaya","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Morishita","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Yamanishi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-0819","authenticated-orcid":false,"given":"Shinsaku","family":"Imashuku","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.5858\/arpa.2017-0403-RS","article-title":"Protein C deficiency","volume":"143","author":"P Dinarvand","year":"2019","journal-title":"Arch Pathol Lab Med"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/1076029618774146","article-title":"Congenital thrombophilia in patients with superior mesenteric venous thrombosis or portal vein thrombosis","volume":"24","author":"I Makoto","year":"2018","journal-title":"Clin Appl Thromb Hemost"},{"issue":"06","key":"ref3","first-page":"646","article-title":"Molecular genetic analysis of severe protein C deficiency","volume":"106","author":"D S Millar","year":"2000","journal-title":"Hum Genet"},{"issue":"31","key":"ref4","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.3748\/wjg.v25.i31.4437","article-title":"Portal vein thrombosis in cirrhosis: why a well-known complication is still matter of debate","volume":"25","author":"M Faccia","year":"2019","journal-title":"World J Gastroenterol"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4254\/wjh.v6.i7.532","article-title":"Portal vein thrombosis with protein C-S deficiency in a non-cirrhotic patient","volume":"6","author":"G A Rodr\u00edguez-Leal","year":"2014","journal-title":"World J Hepatol"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/014107680509800406","article-title":"Portal vein thrombosis despite anticoagulation in a person with diabetes","volume":"98","author":"J H Schweigart","year":"2005","journal-title":"J R Soc Med"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1053\/jinf.2002.1123","article-title":"Clostridium perfringens septicemia with thrombophlebitis of the portal vein","volume":"46","author":"D H Shin","year":"2003","journal-title":"J Infect"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1055\/s-0038-1653885","article-title":"Protein C deficiency: a database of mutations, 1995 update. 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