{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:10:42Z","timestamp":1768317042970,"version":"3.49.0"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":313,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J Pediatr Surg Rep."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute appendicitis is common in children and adolescents. Recently, conservative antibiotic treatment is regarded to be a safe approach to treat uncomplicated appendicitis. It is already established as initial treatment in cases of perforated appendicitis with perityphlitic abscess, commonly followed by interval appendectomy. We report on a 13-year-old boy with uncomplicated appendicitis and a 17-year-old girl with complicated, perforated appendicitis and perityphlitic abscess in whom initially successful antibiotic treatment led to a delay in detection of a carcinoid tumor (neuroendocrine tumor, NET) of the appendix. NET of the appendix, with an incidence of 0.03 to 0.8% in the pediatric population undergoing appendectomy for acute appendicitis, are usually incidental findings after appendectomy with no secure method for detection prior to surgery. Raising concern about this rare but severe disease, we recommend information of patients and their parents about the potential risk of belated diagnosis before opting for conservative their treatment of acute appendicitis. Furthermore, patients successfully treated conservatively require a close follow-up by ultrasound. In presence of any conspicuous finding, especially on imaging, appendectomy should be considered.<\/jats:p>","DOI":"10.1055\/s-0041-1728723","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:01:01Z","timestamp":1636588861000},"page":"e61-e64","source":"Crossref","is-referenced-by-count":5,"title":["Delayed Detection of a Carcinoid Tumor after Conservative Therapy for Appendicitis in a 13-Year-Old Boy and a 17-Year-Old Girl"],"prefix":"10.1055","volume":"09","author":[{"given":"Leonie Annina","family":"Korsch","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology, Kliniken der Stadt K\u00f6ln gGmbH, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Michael Boemers","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology, Kliniken der Stadt K\u00f6ln gGmbH, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Stenzel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology, Kliniken der Stadt K\u00f6ln gGmbH, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wera","family":"Wendenburg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology, Kliniken der Stadt K\u00f6ln gGmbH, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/SLA.0000000000000835","article-title":"Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial","volume":"261","author":"J F Svensson","year":"2015","journal-title":"Ann Surg"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1001\/jamapediatrics.2017.0057","article-title":"Comparison of antibiotic therapy and appendectomy for acute uncomplicated appendicitis in children: a meta-analysis","volume":"171","author":"L Huang","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"20","key":"ref3","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMcp1215006","article-title":"Clinical practice. Acute appendicitis--appendectomy or the \u201cantibiotics first\u201d strategy","volume":"372","author":"D R Flum","year":"2015","journal-title":"N Engl J Med"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.jpedsurg.2017.12.012","article-title":"Outcome of initially nonoperative treatment for acute simple appendicitis in children","volume":"53","author":"R R Gorter","year":"2018","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1055\/s-0038-1668139","article-title":"European Paediatric Surgeons' Association Survey on the management of pediatric appendicitis","volume":"29","author":"A Zani","year":"2019","journal-title":"Eur J Pediatr Surg"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1055\/s-0037-1607292","article-title":"Non-operative management for uncomplicated appendicitis: an option to consider","volume":"28","author":"O Abbo","year":"2018","journal-title":"Eur J Pediatr Surg"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jpedsurg.2017.02.012","article-title":"Unexpected findings after surgery for suspected appendicitis rarely change treatment in pediatric patients; results from a cohort study","volume":"52","author":"R R Gorter","year":"2017","journal-title":"J Pediatr Surg"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-019-01277-0","article-title":"Intermediate-term evaluation of interval appendectomy in the pediatric population","author":"Y Zhang","year":"2019","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jpedsurg.2009.10.039","article-title":"Initial laparoscopic appendectomy versus initial nonoperative management and interval appendectomy for perforated appendicitis with abscess: a prospective, randomized trial","volume":"45","author":"S D St Peter","year":"2010","journal-title":"J Pediatr Surg"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/pbc.25823","article-title":"Surgical management of neuroendocrine tumors of the appendix in children and adolescents: a retrospective French multicenter study of 114 cases","volume":"63","author":"G de Lambert","year":"2016","journal-title":"Pediatr Blood Cancer"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12094-014-1196-4","article-title":"Appendiceal carcinoid tumor in children: implications for less radical surgery?","volume":"17","author":"A D Malkan","year":"2015","journal-title":"Clin Transl Oncol"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1007\/s00431-018-3258-z","article-title":"Long-term outcomes in pediatric appendiceal carcinoids: Turkey experience","volume":"177","author":"F Akova","year":"2018","journal-title":"Eur J Pediatr"},{"issue":"09","key":"ref13","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.jpedsurg.2014.01.005","article-title":"Incidence and outcomes of unexpected pathology findings after appendectomy","volume":"49","author":"H Alemayehu","year":"2014","journal-title":"J Pediatr Surg"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12328-016-0660-9","article-title":"Acute appendicitis with a neuroendocrine tumor G1 (carcinoid): pitfalls of conservative treatment","volume":"9","author":"H A Watanabe","year":"2016","journal-title":"Clin J Gastroenterol"},{"key":"ref15","first-page":"1","article-title":"Karzinoidtumoren der Appendix im Kindes und Jugendalter","volume":"85","author":"L Korsch","year":"2019","journal-title":"chirurgische praxis"}],"container-title":["European Journal of Pediatric Surgery Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1728723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:01:09Z","timestamp":1636588869000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1728723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":15,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2021,1,27]]},"published-print":{"date-parts":[[2021,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1728723","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-7619","2194-7627"],"issn-type":[{"value":"2194-7619","type":"print"},{"value":"2194-7627","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}