{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:50:13Z","timestamp":1775029813539,"version":"3.50.1"},"reference-count":118,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is well known that solid-organ transplant recipients (SOTRs) have a 65- to 100-fold increase in the risk of developing skin cancer, namely, nonmelanoma skin cancers (NMSCs) such as cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC). In addition, these patients are also at increased risk for development of melanoma as well as other less common cutaneous malignancies (Merkel's cell carcinoma, Kaposi's sarcoma). SOTRs with NMSC (namely cSCC) are also at significantly increased risk of poor clinical outcomes including local recurrence, nodal and distant metastasis, and disease-specific death relative to patients who are not immunosuppressed. Increased surveillance and monitoring in patients at risk of aggressive disease and poor outcomes who are on immunosuppression is essential in patients with lung transplants given the high degree of immunosuppression. Increased awareness of risks, treatments, and management allows for improved outcomes in these patients. This article will provide an overview of the risk factors for the development of cutaneous malignancies in organ transplant recipients as well as a detailed discussion of various immunosuppressant and prophylactic medications used in this patient population that contribute to the risk of developing cutaneous malignancies, with an emphasis on NMSC (cSCC and BCC) in lung transplant recipients. Finally, this article includes a discussion on the clinical and dermatologic management of this high-risk immunosuppressed population including a review of topical and systemic agents for field therapy of actinic damage and chemoprevention of keratinocyte carcinomas. In addition, indications for additional treatment and preventive measures such as adjuvant radiation treatment after surgical management of cutaneous malignancies and potential modification of immunosuppressive medication regimens are discussed.<\/jats:p>","DOI":"10.1055\/s-0041-1728798","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T22:33:35Z","timestamp":1621895615000},"page":"483-496","source":"Crossref","is-referenced-by-count":4,"title":["Skin Cancers and Lung Transplant"],"prefix":"10.1055","volume":"42","author":[{"given":"Reason","family":"Wilken","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, NYU Langone Health, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Carucci","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, NYU Langone Health, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, NYU Langone Health, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"issue":"17","key":"ref3","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1056\/NEJMra022137","article-title":"Skin cancers after organ transplantation","volume":"348","author":"S Euvrard","year":"2003","journal-title":"N Engl J Med"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"e13736","DOI":"10.1111\/ctr.13736","article-title":"Skin cancer in transplant recipients: scientific retreat of the international immunosuppression and transplant skin cancer collaborative and skin care in organ transplant patients\u2014Europe","volume":"33","author":"M L Stevenson","year":"2019","journal-title":"Clin Transplant"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1365-2133.2012.10830.x","article-title":"A systematic review of worldwide incidence of nonmelanoma skin cancer","volume":"166","author":"A Lomas","year":"2012","journal-title":"Br J Dermatol"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1001\/jamadermatol.2016.4920","article-title":"Incidence of and risk factors for skin cancer in organ transplant recipients in the United States","volume":"153","author":"G L Garrett","year":"2017","journal-title":"JAMA Dermatol"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jaad.2010.11.062","article-title":"Skin cancer in solid organ transplant recipients: advances in therapy and management: Part I. Epidemiology of skin cancer in solid organ transplant recipients","volume":"65","author":"F O'Reilly Zwald","year":"2011","journal-title":"J Am Acad Dermatol"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/ijc.27765","article-title":"Risk of skin cancer and other malignancies in kidney, liver, heart and lung transplant recipients 1970 to 2008--a Swedish population-based study","volume":"132","author":"B Krynitz","year":"2013","journal-title":"Int J Cancer"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/00007890-199003000-00006","article-title":"Incidence of skin cancer after renal transplantation in the Netherlands","volume":"49","author":"M M Hartevelt","year":"1990","journal-title":"Transplantation"},{"issue":"08","key":"ref10","doi-asserted-by":"crossref","first-page":"923","DOI":"10.2340\/00015555-2148","article-title":"Increased risk of melanoma in organ transplant recipients: systematic 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population of New Zealand renal transplant recipients","volume":"25","author":"K A Mackenzie","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jaad.2014.09.010","article-title":"Incidence and risk factors for skin cancer following lung transplantation","volume":"72","author":"S Rashtak","year":"2015","journal-title":"J Am Acad Dermatol"},{"issue":"07","key":"ref15","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.jid.2016.02.804","article-title":"Prevalence of skin cancer and related skin tumors in high-risk kidney and liver transplant recipients in Queensland, Australia","volume":"136","author":"M R Iannacone","year":"2016","journal-title":"J Invest Dermatol"},{"issue":"09","key":"ref16","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1016\/j.transproceed.2008.09.025","article-title":"Cancer incidence and survival in kidney transplant patients","volume":"40","author":"M D Navarro","year":"2008","journal-title":"Transplant Proc"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/TP.0000000000001286","article-title":"Association of pretransplant skin cancer with posttransplant malignancy, graft failure and death in kidney transplant recipients","volume":"101","author":"W Kang","year":"2017","journal-title":"Transplantation"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7089482","DOI":"10.1155\/2019\/7089482","article-title":"Risk factors for developing nonmelanoma skin cancer after lung transplantation","volume":"2019","author":"N Gr\u00e4ger","year":"2019","journal-title":"J Skin Cancer"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jaad.2012.09.030","article-title":"Fitzpatrick skin phototype is an independent predictor of squamous cell carcinoma risk after solid organ transplantation","volume":"68","author":"R Gogia","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0190-9622(99)70525-6","article-title":"Skin cancer in Australian heart transplant recipients","volume":"40","author":"C S Ong","year":"1999","journal-title":"J Am Acad Dermatol"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1600-6143.2012.04292.x","article-title":"A surveillance model for skin cancer in organ transplant recipients: a 22-year prospective study in an ethnically diverse population","volume":"13","author":"C A Harwood","year":"2013","journal-title":"Am J Transplant"},{"issue":"S 03","key":"ref22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1365-2133.2009.09453.x","article-title":"Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study","volume":"161","author":"C Ulrich","year":"2009","journal-title":"Br J Dermatol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1200\/EDBK_243071","article-title":"Frontline therapy for BRAF-mutated metastatic melanoma: How do you choose, and is there one correct answer?","volume":"39","author":"A C Pavlick","year":"2019","journal-title":"Am Soc Clin Oncol Educ Book"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s40257-018-0355-8","article-title":"Skin cancer following solid organ transplantation: a review of risk factors and models of care","volume":"19","author":"M D Howard","year":"2018","journal-title":"Am J Clin Dermatol"},{"issue":"09","key":"ref25","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/cncr.21404","article-title":"Increased incidence of melanoma in renal transplantation recipients","volume":"104","author":"C S Hollenbeak","year":"2005","journal-title":"Cancer"},{"issue":"06","key":"ref26","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/ajt.12716","article-title":"Survival after cutaneous melanoma in kidney transplant recipients: a population-based matched cohort study","volume":"14","author":"C M Vajdic","year":"2014","journal-title":"Am J Transplant"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.soc.2019.08.001","article-title":"Precision medicine in the treatment of melanoma","volume":"29","author":"K Aderhold","year":"2020","journal-title":"Surg Oncol Clin N Am"},{"issue":"19","key":"ref28","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1200\/JCO.2013.49.2314","article-title":"Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma","volume":"32","author":"E J Lipson","year":"2014","journal-title":"J Clin Oncol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejca.2016.07.026","article-title":"Checkpoint inhibitors in chronic kidney failure and an organ transplant recipient","volume":"67","author":"S Herz","year":"2016","journal-title":"Eur J Cancer"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40425-015-0066-0","article-title":"Safety and efficacy of ipilimumab to treat advanced melanoma in the setting of liver transplantation","volume":"3","author":"R E Morales","year":"2015","journal-title":"J Immunother Cancer"},{"issue":"05","key":"ref31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.7326\/L17-0187","article-title":"Immune checkpoint inhibitor therapy in a liver transplant recipient with melanoma","volume":"167","author":"G Schvartsman","year":"2017","journal-title":"Ann Intern Med"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jaad.2014.05.054","article-title":"Organ transplant recipients with Merkel cell carcinoma have reduced progression-free, overall, and disease-specific survival independent of stage at presentation","volume":"71","author":"S T Arron","year":"2014","journal-title":"J Am Acad Dermatol"},{"issue":"04","key":"ref33","first-page":"29","article-title":"Kaposi's sarcoma after kidney transplantation: a 21-years experience","volume":"7","author":"D Raeisi","year":"2013","journal-title":"Int J Hematol Oncol Stem Cell Res"},{"issue":"02","key":"ref34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/jnci\/dju382","article-title":"Risk of Merkel cell carcinoma after solid organ transplantation","volume":"107","author":"C A Clarke","year":"2015","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/ijc.31735","article-title":"Risk of Kaposi sarcoma after solid organ transplantation in the United States","volume":"143","author":"E K Cahoon","year":"2018","journal-title":"Int J Cancer"},{"issue":"01","key":"ref36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/01.md.0000152372.30370.6f","article-title":"Racial and ethnic variations in incidence and pattern of malignancies after kidney transplantation","volume":"84","author":"M R Moosa","year":"2005","journal-title":"Medicine (Baltimore)"},{"issue":"08","key":"ref37","first-page":"1039","article-title":"Immunosuppression in lung transplantation","volume":"6","author":"J L Scheffert","year":"2014","journal-title":"J Thorac Dis"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s40265-018-0930-6","article-title":"The evolution of lung transplant 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Zhang","year":"2004","journal-title":"ChemBioChem"},{"issue":"05","key":"ref42","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.0022-202X.2005.23858.x","article-title":"Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation","volume":"125","author":"D B Yarosh","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"01","key":"ref43","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0625.2011.01413.x","article-title":"Skin cancer in organ transplant recipients: effects of immunosuppressive medications on DNA repair","volume":"21","author":"C Kuschal","year":"2012","journal-title":"Exp Dermatol"},{"issue":"05","key":"ref44","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/S0041-1345(03)00669-9","article-title":"Influence of immunosuppression on the prevalence of cancer after kidney transplantation","volume":"35","author":"R Marc\u00e9n","year":"2003","journal-title":"Transplant Proc"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0041-1345(98)01928-9","article-title":"Are renal transplant recipients on CsA-based immunosuppressive regimens more likely to develop skin cancer than those on azathioprine and prednisolone?","volume":"31","author":"P Jensen","year":"1999","journal-title":"Transplant Proc"},{"issue":"08","key":"ref46","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1016\/j.transproceed.2010.08.003","article-title":"Incidence and risk factors for nonmelanoma skin cancer after heart transplantation","volume":"42","author":"B D Molina","year":"2010","journal-title":"Transplant Proc"},{"issue":"05","key":"ref47","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1600-6143.2008.02196.x","article-title":"Malignancy after heart transplantation: incidence, prognosis and risk factors","volume":"8","author":"M G Crespo-Leiro","year":"2008","journal-title":"Am J Transplant"},{"issue":"06","key":"ref48","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1600-6143.2004.00450.x","article-title":"Cancer after kidney transplantation in the United States","volume":"4","author":"B L Kasiske","year":"2004","journal-title":"Am J Transplant"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1126\/science.1114233","article-title":"Azathioprine and UVA light generate mutagenic oxidative DNA damage","volume":"309","author":"P O'Donovan","year":"2005","journal-title":"Science"},{"issue":"01","key":"ref50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1039\/C1PP05194F","article-title":"UVA photosensitization of thiopurines and skin cancer in organ transplant recipients","volume":"11","author":"N R Attard","year":"2012","journal-title":"Photochem Photobiol Sci"},{"issue":"11","key":"ref51","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1038\/jid.2015.255","article-title":"Oxidative damage to RPA limits the nucleotide excision repair capacity of human cells","volume":"135","author":"M Guven","year":"2015","journal-title":"J Invest Dermatol"},{"issue":"04","key":"ref52","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1600-0625.2007.00651.x","article-title":"More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine","volume":"17","author":"Y G de Graaf","year":"2008","journal-title":"Exp Dermatol"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1111\/ajt.13863","article-title":"Azathioprine and risk of skin cancer in organ transplant recipients: systematic review and meta-analysis","volume":"16","author":"Z Jiyad","year":"2016","journal-title":"Am J Transplant"},{"issue":"02","key":"ref54","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.3390\/ijms13021886","article-title":"The mTOR signalling pathway in human cancer","volume":"13","author":"H P\u00f3pulo","year":"2012","journal-title":"Int J Mol Sci"},{"issue":"05","key":"ref55","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1097\/01.mlg.0000210544.64659.35","article-title":"Everolimus (RAD) inhibits in vivo growth of murine squamous cell carcinoma (SCC VII)","volume":"116","author":"S S Khariwala","year":"2006","journal-title":"Laryngoscope"},{"issue":"05","key":"ref56","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jaad.2008.09.053","article-title":"Significant response after treatment with the mTOR inhibitor sirolimus in combination with carboplatin and paclitaxel in metastatic melanoma patients","volume":"60","author":"F Meier","year":"2009","journal-title":"J Am Acad Dermatol"},{"issue":"06","key":"ref57","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1074\/jbc.275.6.4336","article-title":"Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts","volume":"275","author":"P Brenneisen","year":"2000","journal-title":"J Biol Chem"},{"issue":"02","key":"ref58","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/ijc.29450","article-title":"Does the nature of residual immune function explain the differential risk of non-melanoma skin cancer development in immunosuppressed organ transplant recipients?","volume":"138","author":"J W Jung","year":"2016","journal-title":"Int J Cancer"},{"key":"ref59","first-page":"628","article-title":"Immunosuppressants and skin cancer in transplant patients: focus on rapamycin","volume":"30","author":"S Euvrard","year":"2004","journal-title":"Dermatol Surg"},{"issue":"05","key":"ref60","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1001\/jamadermatol.2015.5548","article-title":"Association of sirolimus use with risk for skin cancer in a mixed-organ cohort of solid-organ transplant recipients with a history of cancer","volume":"152","author":"P S Karia","year":"2016","journal-title":"JAMA Dermatol"},{"issue":"04","key":"ref61","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMoa1204166","article-title":"Sirolimus and secondary skin-cancer prevention in kidney transplantation","volume":"367","author":"S Euvrard","year":"2012","journal-title":"N Engl J Med"},{"issue":"10","key":"ref62","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1200\/JCO.2012.45.6376","article-title":"Two-year randomized controlled prospective trial converting treatment of stable renal transplant recipients with cutaneous invasive squamous cell carcinomas to sirolimus","volume":"31","author":"J M Hoogendijk-van den Akker","year":"2013","journal-title":"J Clin Oncol"},{"key":"ref63","first-page":"77","article-title":"Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF)","volume":"10","author":"A C Allison","year":"1996","journal-title":"Clin Transplant"},{"issue":"02","key":"ref64","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/ajt.13596","article-title":"Immunosuppressive medications and squamous cell skin carcinoma: nested case-control study within the skin cancer after organ transplant (SCOT) cohort","volume":"16","author":"A E Coghill","year":"2016","journal-title":"Am J Transplant"},{"issue":"10","key":"ref65","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.healun.2006.06.010","article-title":"Mycophenolate mofetil and risk of developing malignancy after orthotopic heart transplantation: analysis of the transplant registry of the International Society for Heart and Lung Transplantation","volume":"25","author":"J O O'Neill","year":"2006","journal-title":"J Heart Lung Transplant"},{"issue":"07","key":"ref66","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.healun.2018.03.012","article-title":"Azathioprine to mycophenolate mofetil transition and risk of squamous cell carcinoma after lung transplantation","volume":"37","author":"M Vos","year":"2018","journal-title":"J Heart Lung Transplant"},{"issue":"05","key":"ref67","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1054\/bjoc.2001.1931","article-title":"Non-melanoma skin cancers and glucocorticoid therapy","volume":"85","author":"M R Karagas","year":"2001","journal-title":"Br J Cancer"},{"issue":"08","key":"ref68","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1093\/ndt\/gfp425","article-title":"Immunosuppressive treatment after solid organ transplantation and risk of post-transplant cutaneous squamous cell carcinoma","volume":"25","author":"A Ingvar","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"09","key":"ref69","doi-asserted-by":"crossref","first-page":"543","DOI":"10.5694\/mja13.00214","article-title":"Lung transplant recipients receiving voriconazole and skin squamous cell carcinoma risk in Australia","volume":"201","author":"C F Neoh","year":"2014","journal-title":"Med J Aust"},{"issue":"07","key":"ref70","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/cid\/cit940","article-title":"Voriconazole-associated cutaneous malignancy: a literature review on photocarcinogenesis in organ transplant recipients","volume":"58","author":"K Williams","year":"2014","journal-title":"Clin Infect Dis"},{"issue":"07","key":"ref71","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/jamadermatol.2020.1141","article-title":"Voriconazole and the risk of keratinocyte carcinomas among lung transplant recipients in the United States","volume":"156","author":"M E D'Arcy","year":"2020","journal-title":"JAMA Dermatol"},{"issue":"07","key":"ref72","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.healun.2012.02.033","article-title":"High cumulative dose exposure to voriconazole is associated with cutaneous squamous cell carcinoma in lung transplant recipients","volume":"31","author":"J P Singer","year":"2012","journal-title":"J Heart Lung Transplant"},{"issue":"01","key":"ref73","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/tri.12865","article-title":"Voriconazole increases the risk for cutaneous squamous cell carcinoma after lung transplantation","volume":"30","author":"N A Kolaitis","year":"2017","journal-title":"Transpl Int"},{"issue":"01","key":"ref74","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/ajt.13431","article-title":"Voriconazole exposure and risk of cutaneous squamous cell carcinoma, Aspergillus colonization, invasive aspergillosis and death in lung transplant recipients","volume":"16","author":"M Mansh","year":"2016","journal-title":"Am J Transplant"},{"issue":"07","key":"ref75","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1001\/jamadermatol.2016.0345","article-title":"Posaconazole substitution for voriconazole-associated phototoxic effects","volume":"152","author":"A A Jacobsen","year":"2016","journal-title":"JAMA Dermatol"},{"issue":"02","key":"ref76","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jaad.2017.08.059","article-title":"Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging","volume":"78","author":"S KT Que","year":"2018","journal-title":"J Am Acad Dermatol"},{"issue":"05","key":"ref77","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/jamadermatol.2013.2139","article-title":"Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study","volume":"149","author":"C D Schmults","year":"2013","journal-title":"JAMA Dermatol"},{"issue":"04","key":"ref78","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1200\/JCO.2012.48.5326","article-title":"Evaluation of American Joint Committee on Cancer, International Union against Cancer, and Brigham and Women's Hospital tumor staging for cutaneous squamous cell carcinoma","volume":"32","author":"P S Karia","year":"2014","journal-title":"J Clin Oncol"},{"issue":"01","key":"ref79","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/jamadermatol.2013.6675","article-title":"Staging for cutaneous squamous cell carcinoma as a predictor of sentinel lymph node biopsy results: meta-analysis of American Joint Committee on Cancer criteria and a proposed alternative system","volume":"150","author":"A R Schmitt","year":"2014","journal-title":"JAMA Dermatol"},{"issue":"02","key":"ref80","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jaad.2017.08.058","article-title":"Cutaneous squamous 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Naylor","year":"1995","journal-title":"Arch Dermatol"},{"issue":"12","key":"ref84","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1158\/1055-9965.EPI-06-0352","article-title":"Prolonged prevention of squamous cell carcinoma of the skin by regular sunscreen use","volume":"15","author":"J C van der Pols","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/978-0-387-78574-5_36","article-title":"Topical treatment of field cancerization","volume":"146","author":"C Ulrich","year":"2009","journal-title":"Cancer Treat Res"},{"issue":"02","key":"ref86","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2133.2006.07616.x","article-title":"Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy","volume":"156","author":"C M Perrett","year":"2007","journal-title":"Br J 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Ulrich","year":"2010","journal-title":"Eur J Dermatol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"27402","DOI":"10.1038\/srep27402","article-title":"Photodynamic therapy inhibit fibroblast growth factor-10 induced keratinocyte differentiation and proliferation through ROS in fibroblast growth factor receptor-2b pathway","volume":"6","author":"M V Gozali","year":"2016","journal-title":"Sci Rep"},{"issue":"04","key":"ref94","first-page":"340","article-title":"Photodynamic therapy in dermatology","volume":"16","author":"P Babilas","year":"2006","journal-title":"Eur J Dermatol"},{"issue":"03","key":"ref95","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.1365-2133.2003.05033.x","article-title":"Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen's disease","volume":"148","author":"A Salim","year":"2003","journal-title":"Br J 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Dermatol"},{"issue":"04","key":"ref102","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1684\/ejd.2017.3025","article-title":"Prevention of non-melanoma skin cancers with nicotinamide in transplant recipients: a case-control study","volume":"27","author":"F Drago","year":"2017","journal-title":"Eur J Dermatol"},{"issue":"11","key":"ref103","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s001250051536","article-title":"Safety of high-dose nicotinamide: a review","volume":"43","author":"M Knip","year":"2000","journal-title":"Diabetologia"},{"issue":"08","key":"ref104","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1517\/14656566.9.8.1363","article-title":"Systemic retinoids in chemoprevention of non-melanoma skin cancer","volume":"9","author":"M Lens","year":"2008","journal-title":"Expert Opin Pharmacother"},{"issue":"04","key":"ref105","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1124\/pr.58.4.4","article-title":"International Union of 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LX. Retinoic acid receptors","volume":"58","author":"P Germain","year":"2006","journal-title":"Pharmacol Rev"},{"issue":"18","key":"ref106","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1158\/0008-5472.CAN-04-1129","article-title":"Retinoic acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis: a possible explanation for tumor preventive action of retinoids","volume":"64","author":"P Mrass","year":"2004","journal-title":"Cancer Res"},{"issue":"31","key":"ref107","doi-asserted-by":"crossref","first-page":"22013","DOI":"10.1074\/jbc.274.31.22013","article-title":"Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation","volume":"274","author":"M J Spinella","year":"1999","journal-title":"J Biol Chem"},{"issue":"22","key":"ref108","doi-asserted-by":"crossref","first-page":"12070","DOI":"10.1073\/pnas.94.22.12070","article-title":"Posttranslational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanism","volume":"94","author":"J Langenfeld","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref109","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1097\/DSS.0000000000002072","article-title":"Use of topical and systemic retinoids in solid organ transplant recipients: update and review of the current literature","volume":"45","author":"M Herold","year":"2019","journal-title":"Dermatol Surg"},{"issue":"08","key":"ref110","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1200\/JCO.1995.13.8.1933","article-title":"Prevention of skin cancer and reduction of keratotic skin lesions during acitretin therapy in renal transplant recipients: a double-blind, placebo-controlled study","volume":"13","author":"J N Bavinck","year":"1995","journal-title":"J Clin Oncol"},{"issue":"04","key":"ref111","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1046\/j.1365-2133.1999.02765.x","article-title":"Skin 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Mungamuri","year":"2006","journal-title":"Cancer Res"},{"issue":"06","key":"ref115","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1600-6143.2009.02997.x","article-title":"Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial","volume":"10","author":"R Salgo","year":"2010","journal-title":"Am J Transplant"},{"issue":"03","key":"ref116","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/TP.0b013e3182247ae2","article-title":"Lower malignancy rates in renal allograft recipients converted to sirolimus-based, calcineurin inhibitor-free immunotherapy: 24-month results from the CONVERT trial","volume":"92","author":"J Alber\u00fa","year":"2011","journal-title":"Transplantation"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14549","article-title":"Mammalian target of 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