{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:37Z","timestamp":1740126817017,"version":"3.37.3"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"DOI":"10.13039\/100008199","name":"RTI International","doi-asserted-by":"crossref","award":["U10 HD063036"],"award-info":[{"award-number":["U10 HD063036"]}],"id":[{"id":"10.13039\/100008199","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008136","name":"Case Western Reserve University","doi-asserted-by":"crossref","award":["U10 HD063072"],"award-info":[{"award-number":["U10 HD063072"]}],"id":[{"id":"10.13039\/100008136","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006474","name":"Columbia University","doi-asserted-by":"crossref","award":["U10 HD063047"],"award-info":[{"award-number":["U10 HD063047"]}],"id":[{"id":"10.13039\/100006474","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"crossref","award":["U10 HD063037"],"award-info":[{"award-number":["U10 HD063037"]}],"id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"crossref","award":["U10 HD063041"],"award-info":[{"award-number":["U10 HD063041"]}],"id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"crossref","award":["U10 HD063020"],"award-info":[{"award-number":["U10 HD063020"]}],"id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008476","name":"University of California Irvine","doi-asserted-by":"crossref","award":["U10 HD063046"],"award-info":[{"award-number":["U10 HD063046"]}],"id":[{"id":"10.13039\/100008476","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"crossref","award":["U10 HD063048"],"award-info":[{"award-number":["U10 HD063048"]}],"id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007747","name":"University of Utah","doi-asserted-by":"crossref","award":["U10 HD063053"],"award-info":[{"award-number":["U10 HD063053"]}],"id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"crossref","award":["UL1TR001108"],"award-info":[{"award-number":["UL1TR001108"]}],"id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008476","name":"University of California Irvine","doi-asserted-by":"crossref","award":["UL1TR000153"],"award-info":[{"award-number":["UL1TR000153"]}],"id":[{"id":"10.13039\/100008476","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007747","name":"University of Utah","doi-asserted-by":"crossref","award":["8UL1TR000105"],"award-info":[{"award-number":["8UL1TR000105"]}],"id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NCATS\/NIH","award":["UL1RR025764"],"award-info":[{"award-number":["UL1RR025764"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n            Objective\u2003Respiratory distress syndrome (RDS) is implicated in 30% of neonatal deaths. Since prostaglandins promote surfactant secretion and labor is associated with a lower risk of RDS in term neonates, it is plausible that synthetic prostaglandin (sPG) exposure is associated with a lower risk of RDS. Thus, we evaluated the association between sPG exposure and RDS in neonates born after the induction of labor (IOL).<\/jats:p><jats:p>\n            Study Design\u2003Secondary analysis of women with singleton pregnancies undergoing IOL at 340\/7 to 420\/7 weeks in the nuMoM2b study, a multicenter prospective cohort of nulliparous women. RDS rates and secondary neonatal outcomes in neonates with intrapartum sPG exposure were compared with those who had IOL with non-sPG methods (e.g., balloon catheter, amniotomy, oxytocin, and laminaria). Logistic regression models estimated the association of sPG with RDS and with secondary outcomes after adjustment for clinical and demographic factors (including gestational age). A sensitivity analysis was performed in which analysis was restricted to those with an admission cervical dilation \u22642\u2009cm.<\/jats:p><jats:p>\n            Results\u2003Of 10,038 women in the total cohort, 3,071 met inclusion criteria; 1,444 were exposed and 1,627 were unexposed to sPGs. Antenatal corticosteroid exposure rates were low (3.0%) and similar between groups. In univariable analysis, neonates with sPG exposure had higher rates of RDS (3.2 vs. 2.0%, odds ratio [OR]: 1.59, 95% confidence interval [CI]: 1.01\u20132.50). This relationship was similar by gestational age at delivery (term vs. preterm, interaction p\u2009=\u20090.14). After adjustment, the association between sPG and RDS was no longer significant (adjusted odds ratio: 1.4, 95% CI: 0.9\u20132.3). When analysis was restricted to subjects with admission cervical dilation of \u22642\u2009cm, there was also no association between sPG exposure and RDS.<\/jats:p><jats:p>\n            Conclusion\u2003In pregnancies between 34 and 42 weeks of gestation, exposure to sPG for cervical ripening or labor induction was not associated with newborn RDS.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1728820","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T22:33:06Z","timestamp":1619994786000},"page":"993-998","source":"Crossref","is-referenced-by-count":0,"title":["Is Exposure to Intrapartum Prostaglandins for Labor Induction Associated with a Lower Incidence of Neonatal Respiratory Distress Syndrome?"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1657-1495","authenticated-orcid":false,"given":"Shannon L.","family":"Son","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah"},{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Intermountain Healthcare, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda A.","family":"Allshouse","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretchen A.","family":"Heinrichs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Denver Health and Hospital Authority, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Garite","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California Irvine, Orange, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Silver","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah"},{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Intermountain Healthcare, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Wapner","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Medical Center, New York City, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Grobman","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith H.","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California Irvine, Orange, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Mercer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, The MetroHealth System, Case Western Reserve University, Clevelend, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torri D.","family":"Metz","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah"},{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Intermountain Healthcare, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,2]]},"reference":[{"key":"ref1","first-page":"553","volume-title":"Acute respiratory disorders","author":"J Whitsett","year":"2005","edition":"6th ed."},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1542\/peds.113.5.1267","article-title":"Low expression of human epithelial sodium channel in airway epithelium of preterm infants with respiratory distress","volume":"113","author":"O Helve","year":"2004","journal-title":"Pediatrics"},{"key":"ref3","first-page":"141","volume-title":"Lung fluid balance during development in neonatal lung disease","author":"R Bland","year":"2008","edition":"1st ed."},{"key":"ref4","volume-title":"The Newborn Baby","author":"V Harrison","year":"2008","edition":"5th 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Med"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"F131","DOI":"10.1136\/adc.2002.025957","article-title":"Maternal intravaginal prostaglandin E2 gel before elective caesarean section at term to induce catecholamine surge in cord blood: randomised, placebo controlled study","volume":"89","author":"M Singh","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"539.e1","DOI":"10.1016\/j.ajog.2015.01.019","article-title":"A description of the methods of the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be (nuMoM2b)","volume":"212","author":"D M Haas","year":"2015","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of 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