{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:49:34Z","timestamp":1768790974200,"version":"3.49.0"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this scoping review was to present the existing literature regarding the relationship between periodontal diseases and coronavirus disease 2019 (COVID-19). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping review guidelines was followed. Articles were retrieved from PubMed\/MEDLINE and Scopus databases and screened to include studies relating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 to periodontal cells and\/or tissues and\/or diseases. Twenty-five papers were included; consisting of six reviews, seven original articles, six short reports, four letters to the editor, one commentary, and one case report. The articles were allocated to three different topics: (i) hypotheses on the relationship between periodontal diseases and COVID-19; (ii) risk factors and comorbidities common to periodontitis and COVID-19; (iii) periodontal manifestations of COVID-19. Certain molecules (angiotensin-converting enzyme-2, furin, cathepsin, TMPRSS2...) that are found at a high level in periodontal tissues, particularly in patients with periodontitis, are involved in the mechanism of entry of SARS-CoV-2 into cells. Periodontopathic bacteria could also play a direct role in the mechanism of entry of SARS-CoV-2 by cleaving the S-protein, and the cytokines produced during periodontitis could add to the cytokine storm found in the severe forms of COVID-19. It thus appears that the treatment of periodontitis, which allows a reduction in periodontopathic bacteria and of the local and systemic inflammation state, could be part of a strategy to prevent the development of severe forms of COVID-19.<\/jats:p>","DOI":"10.1055\/s-0041-1729139","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T22:42:58Z","timestamp":1631227378000},"page":"768-775","source":"Crossref","is-referenced-by-count":25,"title":["Periodontal Diseases and COVID-19: A Scoping Review"],"prefix":"10.1055","volume":"15","author":[{"given":"Lisa","family":"Basso","sequence":"additional","affiliation":[{"name":"Laboratoire des Multimat\u00e9riaux et Interfaces, Claude Bernard University Lyon 1, Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doriane","family":"Chacun","sequence":"additional","affiliation":[{"name":"Laboratoire des Multimat\u00e9riaux et Interfaces, Claude Bernard University Lyon 1, Villeurbanne, France"},{"name":"Faculty of Odontology, Claude Bernard University Lyon 1, Lyon, France"},{"name":"Hospices Civils de Lyon, Service de Consultations et de Traitements Dentaires, Unit\u00e9 Fonctionnelle de Parodontologie, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadiatou","family":"Sy","sequence":"additional","affiliation":[{"name":"Faculty of Odontology, Claude Bernard University Lyon 1, Lyon, France"},{"name":"Hospices Civils de Lyon, Service de Consultations et de Traitements Dentaires, Unit\u00e9 Fonctionnelle de Parodontologie, Lyon, France"},{"name":"INSERM, Controlled Drug Delivery Systems and Biomaterials, University of Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Grosgogeat","sequence":"additional","affiliation":[{"name":"Laboratoire des Multimat\u00e9riaux et Interfaces, Claude Bernard University Lyon 1, Villeurbanne, France"},{"name":"Faculty of Odontology, Claude Bernard University Lyon 1, Lyon, France"},{"name":"Hospices Civils de Lyon, Service de Consultations et de Traitements Dentaires, Clinical Research Unit, Lyon, Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-3731","authenticated-orcid":false,"given":"Kerstin","family":"Gritsch","sequence":"additional","affiliation":[{"name":"Laboratoire des Multimat\u00e9riaux et Interfaces, Claude Bernard University Lyon 1, Villeurbanne, France"},{"name":"Faculty of Odontology, Claude Bernard University Lyon 1, Lyon, France"},{"name":"Hospices Civils de Lyon, Service de Consultations et de Traitements Dentaires, Unit\u00e9 Fonctionnelle de Parodontologie, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2","volume":"5","author":"Coronaviridae Study Group of the International Committee on Taxonomy of Viruses","year":"2020","journal-title":"Nat Microbiol"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"China Novel Coronavirus Investigating and Research Team. 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