{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:07:19Z","timestamp":1793113639716,"version":"4.5.0"},"reference-count":50,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Introduction\u2003Blood transfusion is linked to several risks, most notably the transmission of transfusion-transmitted infections (TTIs), including hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), syphilis, and malaria. The risk posed by these blood-borne infectious agents is high in developing countries, including Pakistan. This fact stresses the need for regular surveillance of TTIs. Therefore, the present study was undertaken to assess the seroprevalence of TTIs at a regional blood center.<\/jats:p><jats:p>Material and Methods\u2003This was a retrospective 4-year descriptive study undertaken at the Regional Blood Centre in Peshawar, Khyber Pakhtunkhwa Province of Pakistan, on the blood donor data from June 2016 to May 2020. A total of 41,817 donors donated blood during the study period and were screened for HBV, HCV, HIV, syphilis, and malaria. To ensure donor privacy, donors were identified via codes and no personal information was available. The data were extracted from the ZAAVIA blood transfusion information system database.<\/jats:p><jats:p>Results\u2003The study included a total of 41,817 donors\u201441,493 (99.22%) males and 324 (0.78%) females. Of them, 22,343 (53.43%) were voluntary donors while 19,474 (46.57%) were replacement donors. An overall TTI prevalence rate of 4.61% was found. The TTI prevalence rate in voluntary donors was 3.90% while 5.42% in replacement donors. The overall prevalence of HBV, HCV, HIV, syphilis, and malaria was 1.95, 1.38, 0.23, 0.91, and 0.14%, respectively.<\/jats:p><jats:p>Conclusion\u2003The current study documented a high prevalence (1,929 out of 41,817, 4.61%) of TTIs, especially in replacement donors (1,057 out of 19,474, 5.42%), and low participation of female donors. The recommendations include the promotion of voluntary blood donors, enrolment of female blood donors, and screening of donated blood through highly sensitive screening assay (i.e., nucleic acid testing).<\/jats:p>","DOI":"10.1055\/s-0041-1729485","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:38:15Z","timestamp":1622075895000},"page":"162-168","source":"Crossref","is-referenced-by-count":23,"title":["Seroprevalence of Transfusion-Transmitted Infections among Voluntary and Replacement Blood Donors at the Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan"],"prefix":"10.25259","volume":"13","author":[{"given":"Noore","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Health, Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal Abdul","family":"Nasir","sequence":"additional","affiliation":[{"name":"Department of Health, Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Waheed","sequence":"additional","affiliation":[{"name":"Islamabad Blood Transfusion Authority, Ministry of National Health Services, Government of Pakistan, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidra","family":"Aslam","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mohtarma Benazir Bhutto Shaheed Medical College, Mirpur, Azad Jammu and Kashmir, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Health, Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhlaaq","family":"Wazeer","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Mirpur University of Science and Technology, Mirpur, Azad Jammu and Kashmir, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Blood Bank, Prince Mohammed bin Abdulaziz Hospital, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Nisar","sequence":"additional","affiliation":[{"name":"Department of Health, Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"issue":"04","key":"ref3","first-page":"293","article-title":"Sero-epidemiology of transfusion-transmissible infectious diseases among blood donors in Osogbo, south-west Nigeria","volume":"7","author":"F I Buseri","year":"2009","journal-title":"Blood Transfus"},{"key":"ref5","first-page":"217","article-title":"Prevalence and trends of hepatitis B, hepatitis C and human 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