{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:52:18Z","timestamp":1790268738316,"version":"4.1.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["HL098554"],"award-info":[{"award-number":["HL098554"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["HL098354"],"award-info":[{"award-number":["HL098354"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NICHD","award":["HD21410"],"award-info":[{"award-number":["HD21410"]}]},{"name":"NICHD","award":["HD27915"],"award-info":[{"award-number":["HD27915"]}]},{"name":"NICHD","award":["HD27917"],"award-info":[{"award-number":["HD27917"]}]},{"name":"NICHD","award":["HD27869"],"award-info":[{"award-number":["HD27869"]}]},{"name":"NICHD","award":["HD34116"],"award-info":[{"award-number":["HD34116"]}]},{"name":"NICHD","award":["HD34208"],"award-info":[{"award-number":["HD34208"]}]},{"name":"NICHD","award":["HD40485"],"award-info":[{"award-number":["HD40485"]}]},{"name":"NICHD","award":["HD40500"],"award-info":[{"award-number":["HD40500"]}]},{"name":"NICHD","award":["HD40512"],"award-info":[{"award-number":["HD40512"]}]},{"name":"NICHD","award":["HD40544"],"award-info":[{"award-number":["HD40544"]}]},{"name":"NICHD","award":["HD40545"],"award-info":[{"award-number":["HD40545"]}]},{"name":"NICHD","award":["HD40560"],"award-info":[{"award-number":["HD40560"]}]},{"name":"NICHD","award":["HD53097"],"award-info":[{"award-number":["HD53097"]}]},{"name":"NICHD","award":["HD53118"],"award-info":[{"award-number":["HD53118"]}]},{"name":"NICHD","award":["HD68268"],"award-info":[{"award-number":["HD68268"]}]},{"name":"NICHD","award":["HD68258"],"award-info":[{"award-number":["HD68258"]}]},{"name":"NICHD","award":["HD68282"],"award-info":[{"award-number":["HD68282"]}]},{"name":"NICHD","award":["HD36801"],"award-info":[{"award-number":["HD36801"]}]},{"name":"National Center for Advancing Translational Sciences, National Institutes of Health","award":["UL1 TR000040"],"award-info":[{"award-number":["UL1 TR000040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n            Objective\u2003In the antenatal late preterm steroids (ALPS) trial betamethasone significantly decreased short-term neonatal respiratory morbidity but increased the risk of neonatal hypoglycemia, diagnosed only categorically (&lt;40\u2009mg\/dL). We sought to better characterize the nature, duration, and treatment for hypoglycemia.<\/jats:p><jats:p>\n            Study Design\u2003Secondary analysis of infants from ALPS, a multicenter trial randomizing women at risk for late preterm delivery to betamethasone or placebo. This study was a reabstraction of all available charts from the parent trial, all of which were requested. Unreviewed charts included those lost to follow-up or from sites not participating in the reabstraction. Duration of hypoglycemia (&lt;40\u2009mg\/dL), lowest value and treatment, if any, were assessed by group. Measures of association and regression models were used where appropriate.<\/jats:p><jats:p>\n            Results\u2003Of 2,831 randomized, 2,609 (92.2%) were included. There were 387 (29.3%) and 223 (17.3%) with hypoglycemia in the betamethasone and placebo groups, respectively (relative risk [RR]: 1.69, 95% confidence interval [CI]: 1.46\u20131.96). Hypoglycemia generally occurred in the first 24\u2009hours in both groups: 374\/385 (97.1%) in the betamethasone group and 214\/222 (96.4%) in the placebo group (p\u2009=\u20090.63). Of 387 neonates with hypoglycemia in the betamethasone group, 132 (34.1%) received treatment, while 73\/223 (32.7%) received treatment in placebo group (p\u2009=\u20090.73). The lowest recorded blood sugar was similar between groups. Most hypoglycemia resolved by 24\u2009hours in both (93.0 vs. 89.3% in the betamethasone and placebo groups, respectively, p\u2009=\u20090.18). Among infants with hypoglycemia in the first 24\u2009hours, the time to resolution was shorter in the betamethasone group (2.80 [interquartile range: 2.03\u20137.03) vs. 3.74 (interquartile range: 2.15\u201315.08) hours; p\u2009=\u20090.002]. Persistence for &gt;72\u2009hours was rare and similar in both groups, nine (2.4%, betamethasone) and four (1.9%, placebo, p\u2009=\u20090.18).<\/jats:p><jats:p>\n            Conclusion\u2003In this cohort, hypoglycemia was transient and most received no treatment, with a quicker resolution in the betamethasone group. Prolonged hypoglycemia was uncommon irrespective of steroid exposure.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1729561","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:27:52Z","timestamp":1622161672000},"page":"532-538","source":"Crossref","is-referenced-by-count":26,"title":["Evaluation of Hypoglycemia in Neonates of Women at Risk for Late Preterm Delivery: An Antenatal Late Preterm Steroids Trial Cohort Study"],"prefix":"10.1055","volume":"40","author":[{"given":"Cynthia","family":"Gyamfi-Bannerman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University, New York City, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Jablonski","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, George Washington University Biostatistics Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center, Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T. N.","family":"Tita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucky","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Saade","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight J.","family":"Rouse","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin A. S.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John M.","family":"Thorp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward K.","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Specialists, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Peaceman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6130-2702","authenticated-orcid":false,"given":"Ronald S.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta K.","family":"Swamy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Norton","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve N.","family":"Caritis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Tolosa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Sorokin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Peter","family":"VanDorsten","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1542\/peds.114.2.372","article-title":"Clinical outcomes of near-term infants","volume":"114","author":"M L Wang","year":"2004","journal-title":"Pediatrics"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1053\/j.semperi.2006.01.005","article-title":"Short-term outcomes of infants born at 35 and 36 weeks gestation: we need to ask more 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