{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:51:04Z","timestamp":1783349464811,"version":"3.54.6"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"Beijing Municipal Science and Technology Project","award":["Z181100001918025"],"award-info":[{"award-number":["Z181100001918025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The best surgical choice for distal femur osteosarcoma in skeletally immature patients remains controversial. A fixed hinged knee prosthesis has been designed to preserve the growth plates in the adjacent tibia, expecting tibial growth to be continued. This study aims to report the (1) clinical outcomes after prosthetic replacement, (2) postoperative complications, and (3) length of discrepancy of the operative tibia with the unaffected tibia. Thirty-four skeletally immature patients (averaged 9 years at surgery; range, 5\u201312 years) with distal femoral osteosarcoma underwent placement of this hinged knee prosthesis between January 2015 and August 2018. Postoperative function and complications were assessed. Length discrepancy was measured using a series of full-length standing anteroposterior radiographs of the bilateral lower extremity. The average follow-up duration was 34 months (2.8 years). In the last follow-up, four patients expired because of pulmonary metastasis. Two patients presented with local recurrence of the soft tissue. Postoperatively, the flexion range of the knee joint range was between 100 and 130\u2009degrees, with an average of 115.2\u2009degrees. The mean functional score of living patients evaluated using the Musculoskeletal Tumor Society scoring system was 89.2% (range, 76.7\u2013100%). Types 1 (three patients), 2 (one patient), 3 (two patients), and 5 (two patients) complications exist. Among them, three patients received revision surgery. The proximal tibial physis still grew after surgery, with an average of 74.3% (range, 30\u2013100%) growth potential compared with the unaffected proximal tibial physis. Moreover, 27 children exhibited tibial length discrepancy compared with the contralateral tibia, and the mean discrepancy in tibial length was 1.1\u2009cm (range, 0.2\u20133.1\u2009cm). This hinged knee prosthesis can keep the growth potential in the adjacent tibia, provides satisfying functional outcomes, and has a lower postoperative complication rate. Thus, it could serve as an alternative intervention for distal femoral osteosarcoma in skeletally immature patients.<\/jats:p>","DOI":"10.1055\/s-0041-1729623","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T22:50:34Z","timestamp":1625007034000},"page":"068-078","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes of Fixed-Hinged Knee Prosthesis for Distal Femoral Osteosarcoma in Skeletally Immature Patients: First Results"],"prefix":"10.1055","volume":"36","author":[{"given":"Zhiqing","family":"Zhao","sequence":"first","affiliation":[{"name":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"first","affiliation":[{"name":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiqiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Tang","sequence":"additional","affiliation":[{"name":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongli","family":"Yang","sequence":"additional","affiliation":[{"name":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4419-0284-9_1","article-title":"The epidemiology of osteosarcoma","volume":"152","author":"G Ottaviani","year":"2009","journal-title":"Cancer Treat Res"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5435\/00124635-200301000-00005","article-title":"Malignant bone tumors: limb sparing versus amputation","volume":"11","author":"M R DiCaprio","year":"2003","journal-title":"J Am Acad Orthop Surg"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11832-010-0270-x","article-title":"Expandable endoprosthesis for limb-sparing surgery in children: long-term results","volume":"4","author":"A Dotan","year":"2010","journal-title":"J Child Orthop"},{"issue":"262","key":"ref4","first-page":"108","article-title":"Limb-salvage surgery in the treatment of osteosarcoma in skeletally immature individuals","author":"H A Finn","year":"1991","journal-title":"Clin Orthop Relat Res"},{"issue":"22","key":"ref5","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1200\/JCO.2002.09.006","article-title":"Limb salvage and amputation in survivors of pediatric lower-extremity bone tumors: what are the long-term implications?","volume":"20","author":"R Nagarajan","year":"2002","journal-title":"J Clin Oncol"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/pbc.22598","article-title":"Seven-year experience of using Repiphysis expandable prosthesis in children with bone tumors","volume":"55","author":"S Saghieh","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2106\/JBJS.19.00621","article-title":"Extendable endoprostheses in skeletally immature patients: a study of 124 children surviving more than 10 years after resection of bone sarcomas","volume":"102","author":"Y Tsuda","year":"2020","journal-title":"J Bone Joint Surg Am"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3928\/01477447-20100429-17","article-title":"Evaluation of a noninvasive expandable prosthesis in musculoskeletal oncology patients for the upper and lower limb","volume":"33","author":"K Beebe","year":"2010","journal-title":"Orthopedics"},{"issue":"22","key":"ref9","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.2106\/JBJS.O.00060","article-title":"Tibial growth disturbance following distal femoral resection and expandable endoprosthetic reconstruction","volume":"97","author":"A Arteau","year":"2015","journal-title":"J Bone Joint Surg Am"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2106\/JBJS.I.01575","article-title":"Outcome of lower-limb preservation with an expandable endoprosthesis after bone tumor resection in children","volume":"94","author":"E R Henderson","year":"2012","journal-title":"J Bone Joint Surg Am"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"e487","DOI":"10.1097\/BPO.0000000000001459","article-title":"Outcomes of expandable prostheses for primary bone malignancies in skeletally immature patients: a systematic review and pooled data analysis","volume":"40","author":"D A Portney","year":"2020","journal-title":"J Pediatr Orthop"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s11999-014-3564-3","article-title":"Frequent complications and severe bone loss associated with the Repiphysis expandable distal femoral prosthesis","volume":"473","author":"C A Cipriano","year":"2015","journal-title":"Clin Orthop Relat Res"},{"issue":"373","key":"ref13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00003086-200004000-00008","article-title":"Expandable endoprosthesis reconstruction in skeletally immature patients with tumors","author":"J J Eckardt","year":"2000","journal-title":"Clin Orthop Relat Res"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1302\/0301-620X.82B2 .9863","article-title":"Extendible replacements of the proximal tibia for bone tumours","volume":"82","author":"R J Grimer","year":"2000","journal-title":"J Bone Joint Surg Br"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1007\/s11999-011-2186-2","article-title":"What are estimated reimbursements for lower extremity prostheses capable of surgical and nonsurgical lengthening?","volume":"470","author":"E R Henderson","year":"2012","journal-title":"Clin Orthop Relat 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First results","volume":"40","author":"F Torner","year":"2016","journal-title":"Int Orthop"},{"issue":"415","key":"ref26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/01.blo.0000093899.12372.25","article-title":"Early multicenter experience with a noninvasive expandable prosthesis","author":"M D Neel","year":"2003","journal-title":"Clin Orthop Relat Res"},{"issue":"03","key":"ref28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1302\/0301-620X.99B3.38018","article-title":"Staged lengthening and reconstruction for children with a leg-length discrepancy after excision of an osteosarcoma around the knee","volume":"99-B","author":"S Kang","year":"2017","journal-title":"Bone Joint J"},{"issue":"01","key":"ref29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jso.23964","article-title":"Temporary hemiarthroplasty with a synthetic device in children with osteosarcoma around the knee as a bridging procedure until skeletal maturity","volume":"112","author":"S H Chung","year":"2015","journal-title":"J Surg Oncol"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ocl.2015.08.027","article-title":"Reconstruction after tumor resection in the growing child","volume":"47","author":"J S Groundland","year":"2016","journal-title":"Orthop Clin North Am"},{"issue":"09","key":"ref32","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1007\/s11999-015-4355-1","article-title":"Are Complications associated with the Repiphysis(\u00ae) expandable distal femoral prosthesis acceptable for its continued use?","volume":"473","author":"E L Staals","year":"2015","journal-title":"Clin Orthop Relat Res"},{"issue":"02","key":"ref33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0966-6362(00)00067-9","article-title":"Leg length discrepancy--an experimental study of compensatory changes in three dimensions using gait analysis","volume":"12","author":"M Walsh","year":"2000","journal-title":"Gait Posture"},{"issue":"426","key":"ref34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/01.blo.0000141386.97866.bb","article-title":"Use of a smooth press-fit stem preserves physeal growth after tumor resection","author":"M D Neel","year":"2004","journal-title":"Clin Orthop Relat Res"},{"issue":"05","key":"ref35","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/os.12525","article-title":"Limb salvage using non-hinged endoprosthesis and staged correction of leg-length discrepancy for children with distal femoral malignant tumors","volume":"11","author":"T Ji","year":"2019","journal-title":"Orthop Surg"},{"issue":"03","key":"ref36","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/BPO.0b013e318286c178","article-title":"Outcome of expandable prostheses in children","volume":"33","author":"P Ruggieri","year":"2013","journal-title":"J Pediatr Orthop"},{"issue":"459","key":"ref37","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/BLO.0b013e3180514c37","article-title":"Coaxial extendible knee equalizes limb length in children with osteogenic sarcoma","volume":"459","author":"A Arkader","year":"2007","journal-title":"Clin Orthop Relat Res"},{"issue":"06","key":"ref38","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1302\/0301-620X.79B6.0790938","article-title":"Growth after extendible endoprosthetic replacement of the distal femur","volume":"79","author":"W P Cool","year":"1997","journal-title":"J Bone Joint Surg Br"},{"issue":"06","key":"ref39","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1302\/0301-620X.79B6.0790927","article-title":"Stanmore custom-made extendible distal femoral replacements. 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