{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:51:46Z","timestamp":1777593106384,"version":"3.51.4"},"reference-count":92,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The shortage of organ donors remains the major limiting factor in lung transplant, with the number of patients on the waiting list largely exceeding the number of available organ donors. Another issue is the low utilization rate seen in some types of donors. Therefore, novel strategies are continuously being explored to increase the donor pool. Advanced age, smoking history, positive serologies, and size mismatch are common criteria that decrease the rate of use when it comes to organ utilization. Questioning these limitations is one of the purposes of this review. Challenging these limitations by adapting novel donor management strategies could help to increase the rate of suitable lungs for transplantation while still maintaining good outcomes. A second goal is to present the latest advances in organ donation after controlled and uncontrolled cardiac death, and also on how to improve these lungs on ex vivo platforms for assessment and future specific therapies. Finally, pushing the limit of the donor envelope also means reviewing some of the recent improvements made in lung preservation itself, as well as upcoming experimental research fields. In summary, donor lung optimization refers to a global care strategy to increase the total numbers of available allografts, and preserve or improve organ quality without paying the price of early-, mid-, or long-term negative outcomes after transplantation.<\/jats:p>","DOI":"10.1055\/s-0041-1729859","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T22:33:35Z","timestamp":1621895615000},"page":"357-367","source":"Crossref","is-referenced-by-count":3,"title":["Pushing the Envelope for Donor Lungs"],"prefix":"10.1055","volume":"42","author":[{"given":"Etienne","family":"Abdelnour-Berchtold","sequence":"additional","affiliation":[{"name":"The Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aadil","family":"Ali","sequence":"additional","affiliation":[{"name":"The Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Cypel","sequence":"additional","affiliation":[{"name":"The Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaf","family":"Keshavjee","sequence":"additional","affiliation":[{"name":"The Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1053-2498(01)00241-8","article-title":"Listing for lung transplantation: life expectancy and transplant effect, stratified by type of end-stage lung disease, the Eurotransplant experience","volume":"20","author":"J De Meester","year":"2001","journal-title":"J Heart Lung Transplant"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1111\/j.1600-6143.2009.02613.x","article-title":"Disease-specific survival benefit of lung transplantation in adults: a national cohort study","volume":"9","author":"A Titman","year":"2009","journal-title":"Am J Transplant"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1513\/pats.200808-098GO","article-title":"Lung donor selection and management","volume":"6","author":"D Van Raemdonck","year":"2009","journal-title":"Proc Am Thorac Soc"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S1053-2498(03)00096-2","article-title":"A review of lung transplant donor acceptability criteria","volume":"22","author":"J B Orens","year":"2003","journal-title":"J Heart Lung Transplant"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/ajt.15677","article-title":"OPTN\/SRTR 2018 annual data report: lung","volume":"20","author":"M Valapour","year":"2020","journal-title":"Am J Transplant"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.athoracsur.2020.04.050","article-title":"Predictors of older donor lung use: are we too good at saying no?","volume":"110","author":"A Y Choi","year":"2020","journal-title":"Ann Thorac Surg"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.healun.2014.08.017","article-title":"Influence of donor and recipient age in lung transplantation","volume":"34","author":"D Hayes Jr.","year":"2015","journal-title":"J Heart Lung Transplant"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.athoracsur.2018.09.066","article-title":"The impact of donor and recipient age: older lung transplant recipients do not require younger lungs","volume":"107","author":"D J Hall","year":"2019","journal-title":"Ann Thorac Surg"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.athoracsur.2017.07.030","article-title":"Does donor age and double versus single lung transplant affect survival of young recipients?","volume":"105","author":"W M Whited","year":"2018","journal-title":"Ann Thorac Surg"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/jamasurg.2019.4079","article-title":"Long-term outcomes of lung transplant with ex vivo lung perfusion","volume":"154","author":"C Divithotawela","year":"2019","journal-title":"JAMA Surg"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/MOT.0000000000000753","article-title":"Survival in adult lung transplantation: where are we in 2020?","volume":"25","author":"S Bos","year":"2020","journal-title":"Curr Opin Organ Transplant"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0140-6736(12)60160-3","article-title":"Effect of donor smoking on survival after lung transplantation: a cohort study of a prospective registry","volume":"380","author":"R S Bonser","year":"2012","journal-title":"Lancet"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.athoracsur.2010.07.073","article-title":"Comparison of outcomes from smoking and nonsmoking donors: thirteen-year experience","volume":"90","author":"M Berman","year":"2010","journal-title":"Ann Thorac Surg"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1579-2129(09)71782-3","article-title":"[Interleukin 8 concentrations in donor bronchoalveolar lavage: impact on primary graft failure in double lung transplant] (in Spanish)","volume":"45","author":"M Almenar","year":"2009","journal-title":"Arch Bronconeumol"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1378\/chest.124.4.1232","article-title":"Clinical risk factors for primary graft failure following lung transplantation","volume":"124","author":"J D Christie","year":"2003","journal-title":"Chest"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/ajrccm.163.1.2005093","article-title":"Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation","volume":"163","author":"A J Fisher","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/ajrccm.165.2.2011151","article-title":"Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation","volume":"165","author":"M De Perrot","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"107557","DOI":"10.1016\/j.drugalcdep.2019.107557","article-title":"Regular cannabis use, with and without tobacco co-use, is associated with respiratory disease","volume":"204","author":"T Winhusen","year":"2019","journal-title":"Drug Alcohol Depend"},{"issue":"15","key":"ref19","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1056\/NEJMoa1014597","article-title":"Normothermic ex vivo lung perfusion in clinical lung transplantation","volume":"364","author":"M Cypel","year":"2011","journal-title":"N Engl J Med"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.healun.2019.09.007","article-title":"Donation after circulatory death in lung transplantation-five-year follow-up from ISHLT Registry","volume":"38","author":"D Van Raemdonck","year":"2019","journal-title":"J Heart Lung Transplant"},{"issue":"05","key":"ref21","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ejcts.2005.01.024","article-title":"Extended donor criteria for lung transplantation--a clinical reality","volume":"27","author":"C Aigner","year":"2005","journal-title":"Eur J Cardiothorac Surg"},{"issue":"09","key":"ref22","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.healun.2020.05.019","article-title":"Influence of the donor history of tobacco and marijuana smoking on early and intermediate lung transplant outcomes","volume":"39","author":"S Okahara","year":"2020","journal-title":"J Heart Lung Transplant"},{"issue":"20","key":"ref23","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1056\/NEJMc1802706","article-title":"The drug-intoxication epidemic and solid-organ transplantation","volume":"378","author":"M R Mehra","year":"2018","journal-title":"N Engl J Med"},{"issue":"27","key":"ref24","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa1512610","article-title":"Sofosbuvir and velpatasvir for HCV genotype 1, 2, 4, 5, and 6 infection","volume":"373","author":"J J Feld","year":"2015","journal-title":"N Engl J Med"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"702","DOI":"10.7326\/M17-2451","article-title":"The drug overdose epidemic and deceased-donor transplantation in the United States a national registry study","volume":"168","author":"C M Durand","year":"2018","journal-title":"Ann Intern Med"},{"issue":"20","key":"ref26","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1056\/NEJMoa1402454","article-title":"Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection","volume":"370","author":"N Afdhal","year":"2014","journal-title":"N Engl J Med"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1056\/NEJMp1505074","article-title":"Transplanting hepatitis C-positive kidneys","volume":"373","author":"P P Reese","year":"2015","journal-title":"N Engl J Med"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/ajt.14137","article-title":"Successful lung transplantation from hepatitis C positive donor to seronegative recipient","volume":"17","author":"B Khan","year":"2017","journal-title":"Am J Transplant"},{"issue":"17","key":"ref29","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1056\/NEJMoa1812406","article-title":"Heart and lung transplants from HCV-infected donors to uninfected recipients","volume":"380","author":"A E Woolley","year":"2019","journal-title":"N Engl J Med"},{"issue":"02","key":"ref30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S2213-2600(19)30268-1","article-title":"Prevention of viral transmission during lung transplantation with hepatitis C-viraemic donors: an open-label, single-centre, pilot trial","volume":"8","author":"M Cypel","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41467-018-08261-z","article-title":"Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion","volume":"10","author":"M Galasso","year":"2019","journal-title":"Nat Commun"},{"issue":"03","key":"ref32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.healun.2018.12.012","article-title":"Implications of declining donor offers with increased risk of disease transmission on waiting list survival in lung transplantation","volume":"38","author":"M L Cox","year":"2019","journal-title":"J Heart Lung Transplant"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0003-4975(94)90405-7","article-title":"Bilateral pulmonary lobe transplantation: left lower and right middle and lower lobes","volume":"57","author":"A Bisson","year":"1994","journal-title":"Ann Thorac Surg"},{"issue":"02","key":"ref34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.healun.2014.09.030","article-title":"Lung size mismatch and primary graft dysfunction after bilateral lung transplantation","volume":"34","author":"M Eberlein","year":"2015","journal-title":"J Heart Lung Transplant"},{"issue":"09","key":"ref35","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/tri.12348","article-title":"Lobar lung transplantation--is it comparable with standard lung transplantation?","volume":"27","author":"A Slama","year":"2014","journal-title":"Transpl Int"},{"issue":"02","key":"ref36","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/ejcts\/ezt353","article-title":"Techniques and results of lobar lung transplantations","volume":"45","author":"D Mitilian","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"issue":"06","key":"ref37","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/ejcts\/ezs541","article-title":"Long-term outcomes of bilateral lobar lung transplantation","volume":"43","author":"I Inci","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"issue":"05","key":"ref38","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.jtcvs.2020.04.166","article-title":"Deceased-donor lobar lung transplant: a successful strategy for small-sized recipients","volume":"161","author":"J L Campo-Canaveral De La Cruz","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/icvts\/ivaa051","article-title":"Does lobar or size-reduced lung transplantation offer satisfactory early and late outcomes?","volume":"31","author":"J Santos Silva","year":"2020","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"03","key":"ref40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00134-020-06341-7","article-title":"Expanding controlled donation after the circulatory determination of death: statement from an international collaborative","volume":"47","author":"B Dom\u00ednguez-Gil","year":"2021","journal-title":"Intensive Care Med"},{"issue":"04","key":"ref41","first-page":"1195","article-title":"Excellent long-term outcome with lungs obtained from uncontrolled donation after circulatory death","volume":"19","author":"E Mi\u00f1ambres","year":"2019","journal-title":"J Heart Lung Transplant"},{"issue":"04","key":"ref42","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/ajt.15237","article-title":"Excellent long-term outcome with lungs obtained from uncontrolled donation after circulatory death","volume":"19","author":"B Suberviola","year":"2019","journal-title":"Am J Transplant"},{"issue":"06","key":"ref43","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1111\/ajt.15795","article-title":"Initial lung transplantation experience with uncontrolled donation after cardiac death in North America","volume":"20","author":"A Healey","year":"2020","journal-title":"Am J Transplant"},{"issue":"10","key":"ref44","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.healun.2015.08.015","article-title":"International Society for Heart and Lung Transplantation donation after circulatory death registry report","volume":"34","author":"M Cypel","year":"2015","journal-title":"J Heart Lung Transplant"},{"issue":"06","key":"ref45","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.athoracsur.2018.07.024","article-title":"Lung transplantation from donation after circulatory death: united states and single-center experience","volume":"106","author":"M A Villavicencio","year":"2018","journal-title":"Ann Thorac Surg"},{"issue":"04","key":"ref46","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/ajt.13599","article-title":"Lung quality and utilization in controlled donation after circulatory determination of death within the United States","volume":"16","author":"J J Mooney","year":"2016","journal-title":"Am J Transplant"},{"issue":"08","key":"ref47","doi-asserted-by":"crossref","first-page":"E173","DOI":"10.1503\/cmaj.200016","article-title":"Early experience with medical assistance in dying in Ontario, Canada: a cohort study","volume":"192","author":"J Downar","year":"2020","journal-title":"CMAJ"},{"issue":"22","key":"ref48","doi-asserted-by":"crossref","first-page":"E604","DOI":"10.1503\/cmaj.181648","article-title":"Deceased organ and tissue donation after medical assistance in dying and other conscious and competent donors: guidance for policy","volume":"191","author":"J Downar","year":"2019","journal-title":"CMAJ"},{"issue":"01","key":"ref49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/ajt.16267","article-title":"Lung donation after medical assistance in dying at home","volume":"21","author":"A Healey","year":"2021","journal-title":"Am J Transplant"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1126\/science.81.2112.621","article-title":"The culture of whole organs","volume":"81","author":"A Carrel","year":"1935","journal-title":"Science"},{"issue":"01","key":"ref51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-5223(19)36469-4","article-title":"Autoperfusion of the heart and lungs for preservation during distant procurement","volume":"93","author":"R L Hardesty","year":"1987","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0140-6736(00)04195-7","article-title":"Transplantation of lungs from a non-heart-beating donor","volume":"357","author":"S Steen","year":"2001","journal-title":"Lancet"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.healun.2008.09.003","article-title":"Technique for prolonged normothermic ex vivo lung perfusion","volume":"27","author":"M Cypel","year":"2008","journal-title":"J Heart Lung Transplant"},{"issue":"07","key":"ref54","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1111\/j.1600-6143.2012.04027.x","article-title":"Clinical ex vivo lung perfusion--pushing the limits","volume":"12","author":"C Aigner","year":"2012","journal-title":"Am J Transplant"},{"issue":"05","key":"ref55","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/ejcts\/ezu245","article-title":"Lung transplantation from initially rejected donors after ex vivo lung reconditioning: the French experience","volume":"46","author":"E Sage","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"issue":"04","key":"ref56","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/ajt.13612","article-title":"Successful transplantation of lungs from an uncontrolled donor after circulatory death preserved in situ by alveolar recruitment maneuvers and assessed by ex vivo lung perfusion","volume":"16","author":"F Valenza","year":"2016","journal-title":"Am J Transplant"},{"issue":"11","key":"ref57","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.healun.2016.05.021","article-title":"Transplantation after ex vivo lung perfusion: a midterm follow-up","volume":"35","author":"A Wallinder","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0140-6736(12)61344-0","article-title":"Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients","volume":"380","author":"G Warnecke","year":"2012","journal-title":"Lancet"},{"issue":"03","key":"ref59","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.healun.2011.10.008","article-title":"Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning","volume":"31","author":"B Zych","year":"2012","journal-title":"J Heart Lung Transplant"},{"issue":"05","key":"ref60","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/ejcts\/ezu239","article-title":"Incidence and severity of primary graft dysfunction after lung transplantation using rejected grafts reconditioned with ex vivo lung perfusion","volume":"46","author":"M Boffini","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"issue":"03","key":"ref61","first-page":"A4809","article-title":"First Danish experience with ex vivo lung perfusion of donor lungs before transplantation","volume":"61","author":"I S Henriksen","year":"2014","journal-title":"Dan Med J"},{"issue":"05","key":"ref62","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/ejcts\/ezy373","article-title":"First experience with ex vivo lung perfusion for initially discarded donor lungs in the Netherlands: a single-centre study","volume":"55","author":"Z L Zhang","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"issue":"01","key":"ref63","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/s12913-019-4154-6","article-title":"Incorporating ex-vivo lung perfusion into the UK adult lung transplant service: an economic evaluation and decision analytic model","volume":"19","author":"N McMeekin","year":"2019","journal-title":"BMC Health Serv Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.med.46.1.235","article-title":"Organ preservation","volume":"46","author":"J H Southard","year":"1995","journal-title":"Annu Rev Med"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.03.002","article-title":"Prediction of donor related lung injury in clinical lung transplantation using a validated ex vivo lung perfusion inflammation score","author":"A T Sage","year":"2021","journal-title":"J Heart Lung Transplant"},{"issue":"01","key":"ref66","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1513\/pats.200809-113GO","article-title":"Infections relevant to lung transplantation","volume":"6","author":"K F Remund","year":"2009","journal-title":"Proc Am Thorac Soc"},{"issue":"04","key":"ref67","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/ajt.13562","article-title":"Ex vivo perfusion treatment of infection in human donor lungs","volume":"16","author":"D Nakajima","year":"2016","journal-title":"Am J Transplant"},{"issue":"09","key":"ref68","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.healun.2013.12.023","article-title":"The effect of ex vivo lung perfusion on microbial load in human donor lungs","volume":"33","author":"A Andreasson","year":"2014","journal-title":"J Heart Lung Transplant"},{"issue":"04","key":"ref69","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s15010-016-0879-x","article-title":"Gaseous nitric oxide to treat antibiotic resistant bacterial and fungal lung infections in patients with cystic fibrosis: a phase I clinical study","volume":"44","author":"C Deppisch","year":"2016","journal-title":"Infection"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.11.150","article-title":"Safety of continuous 12-hour delivery of antimicrobial doses of inhaled nitric oxide during ex vivo lung perfusion","author":"V S Michaelsen","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"08","key":"ref71","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/01.RES.0000125623.56442.20","article-title":"Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling","volume":"94","author":"G M Mutlu","year":"2004","journal-title":"Circ Res"},{"issue":"04","key":"ref72","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1152\/jappl.1996.81.4.1723","article-title":"Terbutaline stimulates alveolar fluid resorption in hyperoxic lung injury","volume":"81","author":"J M Lasnier","year":"1996","journal-title":"J Appl Physiol (1985)"},{"issue":"01","key":"ref73","doi-asserted-by":"crossref","first-page":"L52","DOI":"10.1152\/ajplung.00256.2006","article-title":"Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs","volume":"293","author":"J A Frank","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"07","key":"ref74","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1164\/rccm.201302-0368LE","article-title":"Injury-specific ex vivo treatment of the donor lung: pulmonary thrombolysis followed by successful lung transplantation","volume":"188","author":"T N Machuca","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"06","key":"ref75","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/mt.2012.57","article-title":"Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig","volume":"20","author":"J C Yeung","year":"2012","journal-title":"Mol Ther"},{"issue":"09","key":"ref76","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1089\/hum.2016.070","article-title":"Safety and efficacy of ex vivo donor lung adenoviral IL-10 gene therapy in a large animal lung transplant survival model","volume":"28","author":"T N Machuca","year":"2017","journal-title":"Hum Gene Ther"},{"issue":"09","key":"ref77","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1089\/hum.2016.070","article-title":"Safety and Efficacy of ex vivo donor lung adenoviral IL-10 gene therapy in a large animal lung transplant survival model","volume":"28","author":"T N Machuca","year":"2017","journal-title":"Hum Gene Ther"},{"issue":"01","key":"ref78","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/2394-7438.174832","article-title":"Organ donation and transplantation: an updated overview","volume":"2","author":"D Jha","year":"2016","journal-title":"MAMC J Med Sci"},{"issue":"03","key":"ref79","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1590\/s1679-45082017rb4024","article-title":"Gene therapy: advances, challenges and perspectives","volume":"15","author":"G AR Gon\u00e7alves","year":"2017","journal-title":"Einstein (Sao Paulo)"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.07.104","article-title":"Strategies to prolong homeostasis of ex vivo perfused lungs","author":"M Takahashi","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"04","key":"ref82","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.jtcvs.2019.09.121","article-title":"Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine","volume":"159","author":"A E Hozain","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"07","key":"ref83","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s41591-020-0971-8","article-title":"Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs","volume":"26","author":"A E Hozain","year":"2020","journal-title":"Nat Med"},{"issue":"06","key":"ref84","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0003-4975(10)64763-7","article-title":"Technique of successful clinical double-lung transplantation","volume":"45","author":"G A Patterson","year":"1988","journal-title":"Ann Thorac Surg"},{"issue":"04","key":"ref85","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-5223(19)34354-5","article-title":"A method for safe twelve-hour pulmonary preservation","volume":"98","author":"S H Keshavjee","year":"1989","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"02","key":"ref86","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0022-5223(19)35033-0","article-title":"The role of dextran 40 and potassium in extended hypothermic lung preservation for transplantation","volume":"103","author":"S H Keshavjee","year":"1992","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"03","key":"ref87","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1067\/mtc.2001.109703","article-title":"Low-potassium dextran preservation solution improves lung function after human lung transplantation","volume":"121","author":"S Fischer","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"16","key":"ref88","first-page":"1","article-title":"Outcomes after transplantation of lungs preserved for more than 12\u2009h: a retrospective study","volume":"2600","author":"J C Yeung","year":"2016","journal-title":"Lancet Respir Med"},{"issue":"01","key":"ref89","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.healun.2015.05.017","article-title":"Extension of donor lung preservation with hypothermic storage after normothermic ex vivo lung perfusion","volume":"35","author":"M KY Hsin","year":"2016","journal-title":"J Heart Lung Transplant"},{"issue":"04","key":"ref90","first-page":"773","article-title":"In a canine model, lung preservation at 10 degrees C is superior to that at 4 degrees C. A comparison of two preservation temperatures on lung function and on adenosine triphosphate level measured by phosphorus 31-nuclear magnetic resonance","volume":"103","author":"H Date","year":"1992","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"03","key":"ref91","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0022-5223(19)34378-8","article-title":"The effect of ischemic time and temperature on lung preservation in a simple ex vivo rabbit model used for functional assessment","volume":"98","author":"L S Wang","year":"1989","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"03","key":"ref92","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0022-5223(19)34232-1","article-title":"Changes in alveolar oxygen and carbon dioxide concentration and oxygen consumption during lung preservation. The maintenance of aerobic metabolism during lung preservation","volume":"105","author":"H Date","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"04","key":"ref93","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1016\/j.healun.2020.01.1074","article-title":"Revisiting an old concept in a new era: 36 hour lung preservation using 10\u00b0C static cold storage","volume":"39","author":"A Ali","year":"2020","journal-title":"J Heart Lung Transplant"}],"container-title":["Seminars in Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1729859.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T22:36:07Z","timestamp":1621895767000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1729859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,24]]},"references-count":92,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2021,5,24]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1729859","relation":{},"ISSN":["1069-3424","1098-9048"],"issn-type":[{"value":"1069-3424","type":"print"},{"value":"1098-9048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,24]]}}}