{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:34:15Z","timestamp":1768422855074,"version":"3.49.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003O presente estudo prospectivo, randomizado e controlado foi realizado com 286 pacientes submetidos \u00e0 artroplastia total prim\u00e1ria do joelho (ATJ) com o objetivo de avaliar a efic\u00e1cia da adi\u00e7\u00e3o de antibi\u00f3tico ao cimento \u00f3sseo como forma de preven\u00e7\u00e3o da infec\u00e7\u00e3o p\u00f3s-artroplastia (IPA).<\/jats:p><jats:p>\n          M\u00e9todos\u2003Os pacientes foram randomizados em dois grupos: cimento \u00f3sseo sem antibi\u00f3tico (Sem ATB, n\u2009=\u2009158) ou cimento com antibi\u00f3tico (Com ATB, n\u2009=\u2009128), ao qual foram adicionados 2\u2009g de Vancomicina para 40\u2009g de cimento. Os pacientes foram acompanhados por 24 meses ap\u00f3s a cirurgia.<\/jats:p><jats:p>\n          Resultados\u2003No que diz respeito aos dados demogr\u00e1ficos pr\u00e9-operat\u00f3rios, a distribui\u00e7\u00e3o dos pacientes entre os grupos foi homog\u00eanea (p\u2009&lt;\u20090,05). No per\u00edodo de 24 meses, a taxa global de infec\u00e7\u00e3o foi de 2,09% (6\/286), n\u00e3o havendo diferen\u00e7a (odds ratio [OR]\u2009=\u20091,636; intervalo de confian\u00e7a [IC] 95%: 0,294\u20139,080; p\u2009=\u20090,694) entre o grupo Com ATB (1,56%; 2\/128) e Sem ATB (2,53%; 4\/158). No grupo Sem ATB, a infec\u00e7\u00e3o foi causada por Staphylococcus aureus resistente \u00e0 meticilina (MRSA, na sigla em ingl\u00eas) (n\u2009=\u20092), S. aureus sens\u00edvel \u00e0 meticilina (MSSA, na sigla em ingl\u00eas) (n\u2009=\u20091) e Eschirichia coli (n\u2009=\u20091). Proteus mirabilis e MSSA foram isolados dos pacientes do grupo Com ATB. Dentre as comorbidades, todos os pacientes com IPA eram hipertensos e n\u00e3o diab\u00e9ticos. Dois pacientes com artrite reumatoide que desenvolveram IPA eram do grupo Com ATB.<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003O uso de cimento com ATB reduziu o n\u00famero absoluto de infec\u00e7\u00f5es; por\u00e9m, sem diferen\u00e7a estat\u00edstica entre os grupos. Desta forma, o uso rotineiro n\u00e3o deve ser encorajado.<\/jats:p>","DOI":"10.1055\/s-0041-1729941","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T22:41:27Z","timestamp":1635460887000},"page":"621-627","source":"Crossref","is-referenced-by-count":1,"title":["Infec\u00e7\u00e3o ap\u00f3s artroplastia total prim\u00e1ria de joelho: estudo randomizado prospectivo controlado da adi\u00e7\u00e3o de antibi\u00f3tico ao cimento \u00f3sseo"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-0961","authenticated-orcid":false,"given":"Hugo Alexandre de Araujo Barros","family":"Cobra","sequence":"additional","affiliation":[{"name":"Centro de Aten\u00e7\u00e3o Especializada em Cirurgia do Joelho, Instituto Nacional de Traumatologia e Ortopedia, Rio de Janeiro, RJ, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5855-5808","authenticated-orcid":false,"given":"Alan de Paula","family":"Mozella","sequence":"additional","affiliation":[{"name":"Centro de Aten\u00e7\u00e3o Especializada em Cirurgia do Joelho, Instituto Nacional de Traumatologia e Ortopedia, Rio de Janeiro, RJ, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4967-7576","authenticated-orcid":false,"given":"Pedro Jos\u00e9","family":"Labronici","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Universidade Federal Fluminense, Niter\u00f3i, RJ, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8792-7524","authenticated-orcid":false,"given":"Amanda S.","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Pesquisa, Instituto Nacional de Traumatologia e Ortopedia, Rio de Janeiro, RJ, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5647-2248","authenticated-orcid":false,"given":"Jo\u00e3o Antonio Matheus","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Pesquisa, Instituto Nacional de Traumatologia e Ortopedia, Rio de Janeiro, RJ, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1469-0691.2006.01378.x","article-title":"Outcome of prosthetic knee-associated infection: evaluation of 40 consecutive episodes at a single centre","volume":"12","author":"R R Laffer","year":"2006","journal-title":"Clin Microbiol Infect"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.5435\/JAAOS-D-12-00170","article-title":"Infection prevention in total knee 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