{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:29:56Z","timestamp":1781792996056,"version":"3.54.5"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objectives Periodontitis is a pathological condition of the oral cavity, originating from multiple factors, including microbial, environmental and genetic factors. The vulnerability to several pathologies has been studied with the relationship to genetic polymorphisms, and one of the most prominent is the single nucleotide polymorphisms throughout the genome. The study aimed to find out the association of single nucleotide polymorphism (SNP) of interleukin-1\u03b2 +3954 gene with chronic periodontitis (CP) in Pakistan<\/jats:p><jats:p>Materials and Methods This case\u2013control study was conducted at Dow University of Health Sciences. DNA was extracted from the blood and amplified by using conventional polymerase chain reaction of respective genes followed by sequencing. Mann\u2013Whitney test accessed the difference of clinical parameters between cases and controls, and Fisher\u2019s exact test was applied to access the association of alleles between subjects. Data entered and analyzed using SPSS 21.<\/jats:p><jats:p>Results Significant differences were observed in clinical parameters in cases and controls (p &lt; 0.001). In the IL-1\u03b2 +3954 gene, T alleles were significantly higher in cases as compared with controls (p &lt; 0.001). Genotype CC was significantly dominant in the controls and genotype CT and TT in patients (Chi-square = 19.83, p &lt; 0.001).<\/jats:p><jats:p>Conclusion Within the study\u2019s limits, IL-1\u03b2 +3954 gene polymorphism is associated with periodontitis and is expected to be among the several causes of respective pathology in Pakistan\u2019s population.<\/jats:p>","DOI":"10.1055\/s-0041-1730041","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T22:30:21Z","timestamp":1627165821000},"page":"702-706","source":"Crossref","is-referenced-by-count":8,"title":["Association between Interleukin-1\u03b2 Gene Polymorphism and Chronic Periodontitis"],"prefix":"10.1055","volume":"15","author":[{"given":"Muhammad Mansoor","family":"Majeed","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Altamash Institute of Dental Medicine, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imtiaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Roome","sequence":"additional","affiliation":[{"name":"Section of Molecular Pathology, Department of Pathology, Dow Diagnostic Reference and Research Laboratory, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tehseen","family":"Fatima","sequence":"additional","affiliation":[{"name":"Dow College of Biotechnology, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafat","family":"Amin","sequence":"additional","affiliation":[{"name":"Dow College of Biotechnology, Dow University of Health Sciences, Karachi, 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