{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T10:57:50Z","timestamp":1702637870183},"reference-count":49,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T00:00:00Z","timestamp":1621728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian Journal of Radiology and Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nAim\u2003In this prospective study, we evaluate the role of multiparametric magnetic resonance imaging (mp-MRI) in the assessment of clinically significant prostate cancer at 1.5 T without endorectal coil (ERC).<\/jats:p><jats:p>\nMaterials and Methods\u2003Forty-five men with clinical suspicion of prostate cancer (prostate-specific antigen [PSA] level &gt; 4 ng\/mL, hard prostate on digital rectal examination, and suspicious area at transrectal ultrasound [TRUS]) were evaluated using the mp-MRI protocol over a period of 24 months. All cases were interpreted using the Prostate Imaging Reporting and Data System (PI-RADS) version 2 guidelines and correlated with histopathology.<\/jats:p><jats:p>\nStatistical Analysis Used\u2003A chi-squared test was used for analysis of nominal\/categorical variables and receiver operating characteristic (ROC) curve and one-way analysis of variance (ANOVA) test for continuous variables.<\/jats:p><jats:p>\nResults\u2003The mean age was 67 years and the mean PSA was 38.2 ng\/mL. Eighty percent had prostate cancer and 20% were benign (11% benign prostatic hyperplasia [BPH] and 9% chronic prostatitis). Eighty-six percent of all malignancies were in the peripheral zone. The PI-RADS score for T2-weighted (T2W) imaging showed good sensitivity (81%) but low specificity (67%). The PI-RADS score for diffusion weighted imaging (DWI) with sensitivity of 92% and specificity of 78% had a better accuracy overall than T2W imaging alone. The mean apparent diffusion coefficient (ADC) value (\u00d710\u20136 mm2\/s) was 732 \u00b1 160 in prostate cancer, 1,009 \u00b1 161 in chronic prostatitis, 1,142 \u00b1 82 in BPH, and 663 in a single case of granulomatous prostatitis. Low ADC values (&lt;936) have shown good correlation (area under curve [AUC]: 0.87) with the presence of cancer foci. Inverse correlation was observed between Gleason scores and ADC values. Dynamic contrast-enhanced (DCE) imaging has shown 100% sensitivity\/negative predictive value (NPV), but moderate specificity (67%) in predicting malignancy. The final PI-RADS score had 100% sensitivity and NPV with good overall positive predictive value (PPV) of 95%.<\/jats:p><jats:p>\nConclusions\u2003T2W imaging and DWI remain the mainstays in diagnosis of prostate cancer with mp-MRI. DCE-MRI can be a problem-solving tool in case of equivocal findings. Because assessment with mp-MRI can be subjective, use of the newly developed PI-RADS version 2 scoring system is helpful in accurate interpretation.<\/jats:p>","DOI":"10.1055\/s-0041-1730093","type":"journal-article","created":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T23:03:57Z","timestamp":1621811037000},"source":"Crossref","is-referenced-by-count":1,"title":["Multiparametric Magnetic Resonance Imaging in Evaluation of Clinically Significant Prostate Cancer"],"prefix":"10.1055","author":[{"given":"Sarang M.","family":"Ingole","sequence":"additional","affiliation":[{"name":"Department of Imaging Sciences and Pathology, Saifee Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev U.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Imaging Sciences and Pathology, Saifee Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubair N.","family":"Kazi","sequence":"additional","affiliation":[{"name":"Department of Imaging Sciences and Pathology, Saifee Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rutuja V.","family":"Bhuyar","sequence":"additional","affiliation":[{"name":"Department of Imaging Sciences and Pathology, Saifee Hospital, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,23]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.14740\/wjon1191","article-title":"Epidemiology of prostate cancer","volume":"10","author":"P Rawla","year":"2019","journal-title":"World J Oncol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1055\/s-0039-1683454","article-title":"Multiparametric MRI approach to prostate cancer with a pictorial essay on PI-RADS","volume":"2","author":"P B Popat","year":"2019","journal-title":"J Soc Gastrointest Abdom Radiol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41585-019-0212-4","article-title":"Multiparametric MRI for prostate cancer diagnosis: current status and future directions","volume":"17","author":"A Stabile","year":"2020","journal-title":"Nat Rev Urol"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"J Ferlay","year":"2010","journal-title":"Int J Cancer"},{"issue":"05","key":"ref5","first-page":"465","article-title":"Global variation in cancer incidence and mortality","volume":"81","author":"P N Notani","year":"2001","journal-title":"Curr Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.mgene.2014.07.007","article-title":"Epidemiology of prostate cancer in India","volume":"2","author":"S Jain","year":"2014","journal-title":"Meta Gene"},{"key":"ref7","author":"American Cancer Society","year":"2016"},{"issue":"08","key":"ref8","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1002\/1097-0142(19930415)71:8<2679::AID-CNCR2820710840>3.0.CO;2-R","article-title":"Workgroup #2: screening and detection. 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