{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:56:14Z","timestamp":1762642574162,"version":"3.37.3"},"reference-count":26,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"07","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":60,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fetal growth restriction (FGR) occurs when the fetus does not reach its intrauterine potential for growth and development as a result of compromise in placental function. It is a condition that affects 5 to 10% of pregnancies and is the second most common cause of perinatal morbidity and mortality. Children born with FGR are at risk of impaired neurological and cognitive development and cardiovascular or endocrine diseases in adulthood. The purpose of the present revision is to perform a literature search for evidence on the detection and assessment by ultrasound of brain injury linked to FGR during fetal life. Using a systematic approach and quantitative evaluation as study methodology, we reviewed ultrasound studies of the fetal brain structure of growth-restricted fetuses with objective quality measures. A total of eight studies were identified. High quality studies were identified for measurement of brain volumes; corpus callosum; brain fissure depth measurements, and cavum septi pellucidi width measurement. A low-quality study was available for transverse cerebellar diameter measurement in FGR. Further prospective randomized studies are needed to understand the changes that occur in the brain of fetuses with restricted growth, as well as their correlation with the changes in cognitive development observed.<\/jats:p>","DOI":"10.1055\/s-0041-1730290","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T22:33:03Z","timestamp":1630362783000},"page":"545-559","source":"Crossref","is-referenced-by-count":3,"title":["Prenatal Ultrasound Diagnosis of Biometric changes in the Brain of Growth Restricted Fetuses. A Systematic Review of Literature"],"prefix":"10.61622","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9797-7886","authenticated-orcid":false,"given":"Patr\u00edcia Isabel Pereira","family":"Silva","sequence":"additional","affiliation":[{"name":"Hospital Dr. N\u00e9lio Mendon\u00e7a Funchal, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5451-7775","authenticated-orcid":false,"given":"Miriam","family":"Perez","sequence":"additional","affiliation":[{"name":"Hospital Dr. N\u00e9lio Mendon\u00e7a Funchal, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s00404-017-4341-9","article-title":"Fetal growth restriction: current knowledge","volume":"295","author":"L M Nardozza","year":"2017","journal-title":"Arch Gynecol Obstet"},{"issue":"02","key":"ref2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1159\/000357592","article-title":"Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol","volume":"36","author":"F Figueras","year":"2014","journal-title":"Fetal Diagn Ther"},{"issue":"09","key":"ref3","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/j.0001-6349.2004.00602.x","article-title":"Restricted fetal growth in sudden intrauterine unexplained death","volume":"83","author":"J F Fr\u00f8en","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"02","key":"ref4","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1097\/00003081-200606000-00009","article-title":"Adult consequences of fetal growth restriction","volume":"49","author":"D J Barker","year":"2006","journal-title":"Clin Obstet Gynecol"},{"issue":"02","key":"ref5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1530\/rep.0.1220195","article-title":"Fetal growth restriction: adaptations and consequences","volume":"122","author":"I C McMillen","year":"2001","journal-title":"Reproduction"},{"issue":"06","key":"ref6","doi-asserted-by":"publisher","first-page":"613.e1","DOI":"10.1016\/j.ajog.2009.07.028","article-title":"Cardiovascular responses to maternal betamethasone administration in the intrauterine growth-restricted ovine fetus","volume":"201","author":"S L Miller","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"02","key":"ref7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/pr.2017.37","article-title":"Detection and assessment of brain injury in the growth-restricted fetus and neonate","volume":"82","author":"A Malhotra","year":"2017","journal-title":"Pediatr Res"},{"issue":"08","key":"ref8","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1111\/1471-0528.13435","article-title":"Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review","volume":"122","author":"E Murray","year":"2015","journal-title":"BJOG"},{"issue":"04","key":"ref9","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1113\/JP271402","article-title":"The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome","volume":"594","author":"S L Miller","year":"2016","journal-title":"J Physiol"},{"issue":"01","key":"ref10","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1203\/01.PDR.0000128983.54614.7E","article-title":"Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction","volume":"56","author":"C B Tolsa","year":"2004","journal-title":"Pediatr Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1093\/brain\/awn137","article-title":"Primary cortical folding in the human newborn: an early marker of later functional development","volume":"131","author":"J Dubois","year":"2008","journal-title":"Brain"},{"issue":"04","key":"ref12","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1055\/s-0036-1586752","article-title":"Brain volume and Doppler velocimetry in growth-restricted, small-for-gestational-age, and appropriate-for-gestational-age fetuses","volume":"34","author":"H A Latif","year":"2017","journal-title":"Am J Perinatol"},{"issue":"05","key":"ref13","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/uog.6343","article-title":"Three-dimensional sonographic calculation of the volume of intracranial structures in growth-restricted and appropriate-for-gestational age fetuses","volume":"33","author":"A Benavides-Serralde","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"08","key":"ref14","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.7863\/ultra.34.8.1397","article-title":"Assessment of intracranial structure volumes in fetuses with growth restriction by 3-dimensional sonography using the extended imaging virtual organ computer-aided analysis method","volume":"34","author":"A CR Caetano","year":"2015","journal-title":"J Ultrasound Med"},{"issue":"12","key":"ref15","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1002\/pd.2840","article-title":"Corpus callosum growth in normal and growth-restricted fetuses","volume":"31","author":"I Goldstein","year":"2011","journal-title":"Prenat Diagn"},{"issue":"02","key":"ref16","doi-asserted-by":"publisher","first-page":"126.e1","DOI":"10.1016\/j.ajog.2013.04.008","article-title":"Differences in cortical development assessed by fetal MRI in late-onset intrauterine growth restriction","volume":"209","author":"G Ega\u00f1a-Ugrinovic","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"05","key":"ref17","doi-asserted-by":"publisher","first-page":"e0217538","DOI":"10.1371\/journal.pone.0217538","article-title":"Three-dimensional ultrasound imaging of fetal brain fissures in the growth restricted fetus","volume":"14","author":"S C Husen","year":"2019","journal-title":"PLoS One"},{"issue":"04","key":"ref18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1515\/jpm-2019-0401","article-title":"Fetal brain development in small-for-gestational age (SGA) fetuses and normal controls","volume":"48","author":"E Jacob","year":"2020","journal-title":"J Perinat Med"},{"issue":"12","key":"ref19","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1002\/pd.1970141202","article-title":"Intrauterine growth retardation and fetal transverse cerebellar diameter","volume":"14","author":"R J Snijders","year":"1994","journal-title":"Prenat Diagn"},{"issue":"12","key":"ref20","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1111\/j.1471-0528.2012.03451.x","article-title":"Systematic review of methodology used in ultrasound studies aimed at creating charts of fetal size","volume":"119","author":"C Ioannou","year":"2012","journal-title":"BJOG"},{"issue":"05","key":"ref21","first-page":"972","article-title":"Early assessment of brain maturation by MR imaging segmentation in neonates and premature infants","volume":"27","author":"A Zacharia","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"issue":"08","key":"ref22","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.neubiorev.2007.10.002","article-title":"Neural compensation after early lesions: a clinical view of animal experiments","volume":"31","author":"A Gramsbergen","year":"2007","journal-title":"Neurosci Biobehav Rev"},{"issue":"01","key":"ref23","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/uog.5377","article-title":"Changes in regional fetal cerebral blood flow perfusion in relation to hemodynamic deterioration in severely growth-restricted fetuses","volume":"32","author":"E Hernandez-Andrade","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"05","key":"ref24","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1203\/01.PDR.0000119369.21770.7A","article-title":"Sonographic biometry of the frontal lobe in normal and growth-restricted neonates","volume":"55","author":"I R Makhoul","year":"2004","journal-title":"Pediatr Res"},{"issue":"03","key":"ref25","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1542\/peds.2006-0553","article-title":"Detection of impaired growth of the corpus callosum in premature infants","volume":"118","author":"N G Anderson","year":"2006","journal-title":"Pediatrics"},{"issue":"02","key":"ref26","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1159\/000346566","article-title":"Fetal brain MRI texture analysis identifies different microstructural patterns in adequate and small for gestational age fetuses at term","volume":"33","author":"M Sanz-Cort\u00e9s","year":"2013","journal-title":"Fetal Diagn Ther"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/prenatal-ultrasound-diagnosis-of-biometric-changes-in-the-brain-of-growth-restricted-fetuses-a-systematic-review-of-literature\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1730290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T20:54:25Z","timestamp":1721336065000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/prenatal-ultrasound-diagnosis-of-biometric-changes-in-the-brain-of-growth-restricted-fetuses-a-systematic-review-of-literature\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":26,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2021,8,30]]},"published-print":{"date-parts":[[2021,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1730290","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"type":"print","value":"0100-7203"},{"type":"electronic","value":"1806-9339"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}